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• W2890141746 abstract "Pancreatic ductal adenocarcinoma ( PDAC ) is an aggressive and lethal cancer that is typically diagnosed at a later stage with metastases and is difficult to treat. Therefore, investigating the mechanism of PDAC initiation is important to aid early‐stage cancer detection. PRDM 14 is a transcription factor that maintains pluripotency in embryonic stem cells and is overexpressed in several cancers. We previously reported that PRDM 14 is overexpressed and regulates cancer stem‐like phenotypes in PDAC , and herein, we assess whether PRDM 14 expression increases prior to tumorigenesis. Through immunohistochemistry analyses of clinical tissues, we detected PRDM 14‐positive cells in precursor pancreatic intraepithelial neoplasia and chronic pancreatitis, which is a risk factor for PDAC , lesions. PRDM 14 staining in chronic pancreatitis was as high as that in PDAC and cancer adjacent tissues. We induced pancreatitis in mouse models by cerulein injection, and observed that PRDM 14 expression increased in chronic pancreatitis models but not in control or acute pancreatitis mice. Moreover, cerulein treatment increased PRDM 14 expression in PK ‐1 and As PC ‐1 pancreatic cancer cell lines. Our results suggest that inflammation increases the expression of PRDM 14, which regulates cancer stem‐like phenotypes, and this occurs prior to PDAC initiation and progression." @default.
• W2890141746 created "2018-09-27" @default.
• W2890141746 creator A5050211720 @default.
• W2890141746 creator A5061470532 @default.
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• W2890141746 date "2018-09-17" @default.
• W2890141746 modified "2023-10-17" @default.
• W2890141746 title "<scp>PRDM</scp>14 is overexpressed in chronic pancreatitis prior to pancreatic cancer" @default.
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• W2890141746 doi "https://doi.org/10.1002/2211-5463.12519" @default.
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