FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890142664> ?p ?o ?g. }

• W2890142664 endingPage "849" @default.
• W2890142664 startingPage "840" @default.
• W2890142664 abstract "Myocardial ischemia–reperfusion (MI/R) injury is a crucial cause for mortality throughout the world. Recent studies indicated that melatonin might exert profound cardio-protective effect in MI/R injury. However, the underlying mechanisms are not completely understood. In the current study, we aimed to explore the potential effect of melatonin in the pathological process of MI/R. Both in vivo MI/R model and in vitro H9c2 cell line simulated I/R (SIR) model were applied with or without melatonin supplementation. We found that Sirtuin3 (Sirt3) expression and activity were markedly decreased under MI/R and SIR conditions. Melatonin treatment significantly increased myocardial Sirt3 expression, and alleviated MI/R-induced cardiac morphology changes and cardiac dysfunction, as well as myocardial apoptosis level. In addition, DHE and JC-1 staining results demonstrated that melatonin reduced mitochondrial reactive oxygen species (ROS) generation and restored ATP production after SIR injury via elevating Sirt3 expression. By using siRNA targeting Sirt3, we confirmed that the beneficial effects of melatonin were dependent on Sirt3, which in turn deacetylated and activated manganese superoxide dismutase (MnSOD). Collectively, the current study demonstrated the protective effect of melatonin against MI/R injury via alleviating myocardial oxidative stress. Moreover, these beneficial effects were associated with the deacetylation modification of Sirt3 on MnSOD." @default.
• W2890142664 created "2018-09-27" @default.
• W2890142664 creator A5037558052 @default.
• W2890142664 creator A5051610166 @default.
• W2890142664 creator A5059944329 @default.
• W2890142664 creator A5060327489 @default.
• W2890142664 creator A5068975569 @default.
• W2890142664 creator A5081675173 @default.
• W2890142664 creator A5088063692 @default.
• W2890142664 date "2018-08-03" @default.
• W2890142664 modified "2023-09-29" @default.
• W2890142664 title "Melatonin protects against myocardial ischemia–reperfusion injury by elevating Sirtuin3 expression and manganese superoxide dismutase activity" @default.
• W2890142664 cites W1933021800 @default.
• W2890142664 cites W1965109791 @default.
• W2890142664 cites W1970516435 @default.
• W2890142664 cites W1979491078 @default.
• W2890142664 cites W1980756616 @default.
• W2890142664 cites W1996235123 @default.
• W2890142664 cites W2031661979 @default.
• W2890142664 cites W2032517215 @default.
• W2890142664 cites W2077388370 @default.
• W2890142664 cites W2084806669 @default.
• W2890142664 cites W2111476570 @default.
• W2890142664 cites W2118384668 @default.
• W2890142664 cites W2170021382 @default.
• W2890142664 cites W2173193594 @default.
• W2890142664 cites W2182082299 @default.
• W2890142664 cites W2363388170 @default.
• W2890142664 cites W2479394673 @default.
• W2890142664 cites W2527692420 @default.
• W2890142664 cites W2549645750 @default.
• W2890142664 cites W2555339002 @default.
• W2890142664 cites W2563793913 @default.
• W2890142664 cites W2575397619 @default.
• W2890142664 cites W2581521665 @default.
• W2890142664 cites W2612482748 @default.
• W2890142664 cites W2612697984 @default.
• W2890142664 cites W2626467057 @default.
• W2890142664 cites W2693222384 @default.
• W2890142664 cites W2734669376 @default.
• W2890142664 cites W4292172722 @default.
• W2890142664 doi "https://doi.org/10.1080/10715762.2018.1461215" @default.
• W2890142664 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30208798" @default.
• W2890142664 hasPublicationYear "2018" @default.
• W2890142664 type Work @default.
• W2890142664 sameAs 2890142664 @default.
• W2890142664 citedByCount "22" @default.
• W2890142664 countsByYear W28901426642019 @default.
• W2890142664 countsByYear W28901426642020 @default.
• W2890142664 countsByYear W28901426642021 @default.
• W2890142664 countsByYear W28901426642022 @default.
• W2890142664 countsByYear W28901426642023 @default.
• W2890142664 crossrefType "journal-article" @default.
• W2890142664 hasAuthorship W2890142664A5037558052 @default.
• W2890142664 hasAuthorship W2890142664A5051610166 @default.
• W2890142664 hasAuthorship W2890142664A5059944329 @default.
• W2890142664 hasAuthorship W2890142664A5060327489 @default.
• W2890142664 hasAuthorship W2890142664A5068975569 @default.
• W2890142664 hasAuthorship W2890142664A5081675173 @default.
• W2890142664 hasAuthorship W2890142664A5088063692 @default.
• W2890142664 hasBestOaLocation W28901426642 @default.
• W2890142664 hasConcept C126322002 @default.
• W2890142664 hasConcept C134018914 @default.
• W2890142664 hasConcept C138488276 @default.
• W2890142664 hasConcept C181199279 @default.
• W2890142664 hasConcept C185592680 @default.
• W2890142664 hasConcept C190283241 @default.
• W2890142664 hasConcept C2775838275 @default.
• W2890142664 hasConcept C2776151105 @default.
• W2890142664 hasConcept C2778182776 @default.
• W2890142664 hasConcept C2780114680 @default.
• W2890142664 hasConcept C2780561631 @default.
• W2890142664 hasConcept C48349386 @default.
• W2890142664 hasConcept C541997718 @default.
• W2890142664 hasConcept C55493867 @default.
• W2890142664 hasConcept C71924100 @default.
• W2890142664 hasConcept C75520062 @default.
• W2890142664 hasConcept C98274493 @default.
• W2890142664 hasConceptScore W2890142664C126322002 @default.
• W2890142664 hasConceptScore W2890142664C134018914 @default.
• W2890142664 hasConceptScore W2890142664C138488276 @default.
• W2890142664 hasConceptScore W2890142664C181199279 @default.
• W2890142664 hasConceptScore W2890142664C185592680 @default.
• W2890142664 hasConceptScore W2890142664C190283241 @default.
• W2890142664 hasConceptScore W2890142664C2775838275 @default.
• W2890142664 hasConceptScore W2890142664C2776151105 @default.
• W2890142664 hasConceptScore W2890142664C2778182776 @default.
• W2890142664 hasConceptScore W2890142664C2780114680 @default.
• W2890142664 hasConceptScore W2890142664C2780561631 @default.
• W2890142664 hasConceptScore W2890142664C48349386 @default.
• W2890142664 hasConceptScore W2890142664C541997718 @default.
• W2890142664 hasConceptScore W2890142664C55493867 @default.
• W2890142664 hasConceptScore W2890142664C71924100 @default.
• W2890142664 hasConceptScore W2890142664C75520062 @default.
• W2890142664 hasConceptScore W2890142664C98274493 @default.
• W2890142664 hasIssue "8" @default.
• W2890142664 hasLocation W28901426641 @default.
• W2890142664 hasLocation W28901426642 @default.

• next