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• W2890143132 abstract "Methylglyoxal (MG) is a reactive dicarbonyl compound produced by glycolytic processing, which has been identified as a precursor of advanced glycation end products. Elevated MG levels in patients with diabetes are believed to contribute to diabetic complications, including bone defects. The objective of this study was to evaluate the effect of MG on RANKL-induced osteoclast differentiation in RAW264.7 cells, a murine macrophage cell line. RAW264.7 cells were cultured in medium containing 50 ng/mL RANKL and different concentrations of MG. Tartrate-resistant acid phosphatase (TRAP) activity and osteoclast bone resorbing activity were assessed and changes in intracellular calcium concentration, mitochondrial mass, mitochondrial membrane potential, and glyoxalase I level were examined. In addition, real-time RT-PCR assay was used to analyse osteoclast-associated genes. MG markedly inhibited RANKL-induced TRAP activity. MG treatment resulted in a significant decrease in intracellular calcium concentration, mitochondrial mass, mitochondrial membrane potential, and glyoxalase I level during osteoclastogenesis. In addition, MG increased the formation of mitochondrial superoxide. Quantitative reverse transcriptase-polymerase chain reaction revealed increased expression of the TRAF6, GAB2, ERK1, c-Fos, NFATc1, CLCN7, and OSTM1 genes, decreased expression of TCIRG and carbonic anhydrase II, and unchanged expression of cathepsin K and MMP-9 upon MG treatment. MG had no effect on the bone resorbing activity of osteoclasts. Our findings indicate that MG inhibits TRAP and glyoxalase I activity and impairs mitochondrial function in osteoclasts. Further validation of the underlying pathway is necessary." @default.
• W2890143132 created "2018-09-27" @default.
• W2890143132 creator A5025413315 @default.
• W2890143132 creator A5042596963 @default.
• W2890143132 creator A5073922751 @default.
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• W2890143132 date "2018-12-01" @default.
• W2890143132 modified "2023-10-12" @default.
• W2890143132 title "Effects of methylglyoxal on RANKL-induced osteoclast differentiation in RAW264.7 cells" @default.
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• W2890143132 doi "https://doi.org/10.1016/j.cbi.2018.09.005" @default.
• W2890143132 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30217477" @default.
• W2890143132 hasPublicationYear "2018" @default.
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