FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890143258> ?p ?o ?g. }

• W2890143258 endingPage "409" @default.
• W2890143258 startingPage "404" @default.
• W2890143258 abstract "Intrauterine infection is a major cause of immune imbalance at the maternal-fetal interface, which leads to spontaneous abortion, premature rupture of the fetal membranes, and preterm birth. Human amniotic epithelial cells (hAECs) play a fundamental role in the maintenance of pregnancy. We hypothesize that bacteria influence the immunomodulatory effects of hAECs through stimulation of Toll-like receptors (TLRs). Here, we investigated how lipopolysaccharide (LPS) as a bacterial component affects anti-inflammatory and pro-inflammatory cytokines production of hAECs. Human placentas were obtained from six healthy pregnant women and hAECs were isolated. The phenotypic characteristics of hAECs were determined by flow cytometry. The hAECs (4 × 105 cells/ml) were cultured in the presence or absence of LPS (5 μg/ml). The viability of the cells was assessed and culture supernatants of hAECs were collected after 24, 48 and 72 h of incubation. The levels of transforming growth factor-beta1 (TGF-β1), interleukin-4 (IL-4), tumor necrosis factor-alpha (TNF-α), interleukin-17 A (IL-17A), and interferon-gamma (IFN-γ) were measured by ELISA. Our data showed that LPS treatment did not affect the viability of hAECs, while had a stimulatory effect on TGF-β1 production of hAECs (p < 0.001). A significant reduction in IL-4 production of LPS-stimulated hAECs was observed (p < 0.05). LPS enhanced the production of TNF-α and IL-17 A of hAECs (p < 0.05–0.0001). The IFN-γ level was only detectable in two culture supernatants of hAECs, and the level was unchanged after stimulation with LPS. Based on these findings, LPS may play a pivotal role in immune imbalance at the feto-maternal interface through affecting anti-inflammatory and pro-inflammatory cytokines production of hAECs." @default.
• W2890143258 created "2018-09-27" @default.
• W2890143258 creator A5002991263 @default.
• W2890143258 creator A5029966195 @default.
• W2890143258 creator A5050922857 @default.
• W2890143258 creator A5079764464 @default.
• W2890143258 date "2018-12-01" @default.
• W2890143258 modified "2023-09-24" @default.
• W2890143258 title "The effect of lipopolysaccharide on anti-inflammatory and pro-inflammatory cytokines production of human amniotic epithelial cells" @default.
• W2890143258 cites W1971739874 @default.
• W2890143258 cites W1983895762 @default.
• W2890143258 cites W1988419379 @default.
• W2890143258 cites W1991933056 @default.
• W2890143258 cites W2003117475 @default.
• W2890143258 cites W2018020394 @default.
• W2890143258 cites W2023985643 @default.
• W2890143258 cites W2027809616 @default.
• W2890143258 cites W2057056307 @default.
• W2890143258 cites W2063096500 @default.
• W2890143258 cites W2063390572 @default.
• W2890143258 cites W2077067540 @default.
• W2890143258 cites W2085752080 @default.
• W2890143258 cites W2115289404 @default.
• W2890143258 cites W2118857294 @default.
• W2890143258 cites W2129379081 @default.
• W2890143258 cites W2136943429 @default.
• W2890143258 cites W2144926476 @default.
• W2890143258 cites W2164197794 @default.
• W2890143258 cites W2166319140 @default.
• W2890143258 cites W2326987869 @default.
• W2890143258 cites W2766988816 @default.
• W2890143258 cites W2801095061 @default.
• W2890143258 cites W2805467049 @default.
• W2890143258 cites W2809079840 @default.
• W2890143258 cites W49611453 @default.
• W2890143258 doi "https://doi.org/10.1016/j.repbio.2018.09.005" @default.
• W2890143258 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30220549" @default.
• W2890143258 hasPublicationYear "2018" @default.
• W2890143258 type Work @default.
• W2890143258 sameAs 2890143258 @default.
• W2890143258 citedByCount "15" @default.
• W2890143258 countsByYear W28901432582020 @default.
• W2890143258 countsByYear W28901432582021 @default.
• W2890143258 countsByYear W28901432582022 @default.
• W2890143258 countsByYear W28901432582023 @default.
• W2890143258 crossrefType "journal-article" @default.
• W2890143258 hasAuthorship W2890143258A5002991263 @default.
• W2890143258 hasAuthorship W2890143258A5029966195 @default.
• W2890143258 hasAuthorship W2890143258A5050922857 @default.
• W2890143258 hasAuthorship W2890143258A5079764464 @default.
• W2890143258 hasConcept C123012128 @default.
• W2890143258 hasConcept C138851942 @default.
• W2890143258 hasConcept C16685009 @default.
• W2890143258 hasConcept C172680121 @default.
• W2890143258 hasConcept C17991360 @default.
• W2890143258 hasConcept C185592680 @default.
• W2890143258 hasConcept C202751555 @default.
• W2890143258 hasConcept C203014093 @default.
• W2890143258 hasConcept C20875687 @default.
• W2890143258 hasConcept C2778690821 @default.
• W2890143258 hasConcept C2778754761 @default.
• W2890143258 hasConcept C2779234561 @default.
• W2890143258 hasConcept C2780646683 @default.
• W2890143258 hasConcept C54355233 @default.
• W2890143258 hasConcept C553184892 @default.
• W2890143258 hasConcept C55493867 @default.
• W2890143258 hasConcept C71924100 @default.
• W2890143258 hasConcept C74172505 @default.
• W2890143258 hasConcept C86803240 @default.
• W2890143258 hasConcept C8891405 @default.
• W2890143258 hasConceptScore W2890143258C123012128 @default.
• W2890143258 hasConceptScore W2890143258C138851942 @default.
• W2890143258 hasConceptScore W2890143258C16685009 @default.
• W2890143258 hasConceptScore W2890143258C172680121 @default.
• W2890143258 hasConceptScore W2890143258C17991360 @default.
• W2890143258 hasConceptScore W2890143258C185592680 @default.
• W2890143258 hasConceptScore W2890143258C202751555 @default.
• W2890143258 hasConceptScore W2890143258C203014093 @default.
• W2890143258 hasConceptScore W2890143258C20875687 @default.
• W2890143258 hasConceptScore W2890143258C2778690821 @default.
• W2890143258 hasConceptScore W2890143258C2778754761 @default.
• W2890143258 hasConceptScore W2890143258C2779234561 @default.
• W2890143258 hasConceptScore W2890143258C2780646683 @default.
• W2890143258 hasConceptScore W2890143258C54355233 @default.
• W2890143258 hasConceptScore W2890143258C553184892 @default.
• W2890143258 hasConceptScore W2890143258C55493867 @default.
• W2890143258 hasConceptScore W2890143258C71924100 @default.
• W2890143258 hasConceptScore W2890143258C74172505 @default.
• W2890143258 hasConceptScore W2890143258C86803240 @default.
• W2890143258 hasConceptScore W2890143258C8891405 @default.
• W2890143258 hasFunder F4320322245 @default.
• W2890143258 hasIssue "4" @default.
• W2890143258 hasLocation W28901432581 @default.
• W2890143258 hasLocation W28901432582 @default.
• W2890143258 hasOpenAccess W2890143258 @default.
• W2890143258 hasPrimaryLocation W28901432581 @default.
• W2890143258 hasRelatedWork W1987741773 @default.
• W2890143258 hasRelatedWork W1988079980 @default.

• next