FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890145654> ?p ?o ?g. }

• W2890145654 abstract "Early plasmablast induction is a hallmark of Plasmodium infection and is thought to contribute to the control of acute parasite burden. Although long understood to be a T-cell dependent phenomenon, regulation of early plasmablast differentiation, however, is poorly understood. Here, we identify a population of CD4+ T cells that express the innate NK cell marker NK1.1 as an important source of T cell help for early plasmablast and parasite-specific Ab production. Interestingly, NK1.1+ CD4+ T cells arise from conventional, naive NK1.1- CD4+ T cells, and their generation is independent of CD1d but critically reliant on MHC-II. CD4+ T cells that express NK1.1 early after activation produce IFN- and IL-21, and express the follicular helper T (Tfh) cell markers ICOS, PD-1 and CXCR5 more frequently than NK1.1- CD4+ T cells. Further analysis of this population revealed that NK1.1+ Tfh-like cells were more regularly complexed with plasmablasts than NK1.1- Tfh-like cells. Ultimately, depletion of NK1.1+ cells impaired class-switched parasite-specific antibody production during early Plasmodium yoelii infection. Together, these data suggest that expression of NK1.1 defines a population of rapidly expanding effector CD4+ T cells that specifically promote plasmablast induction during Plasmodium infection and represent a subset of T cells whose modulation could promote effective vaccine design." @default.
• W2890145654 created "2018-09-27" @default.
• W2890145654 creator A5003558705 @default.
• W2890145654 creator A5026529034 @default.
• W2890145654 creator A5043321954 @default.
• W2890145654 creator A5066445201 @default.
• W2890145654 date "2018-10-15" @default.
• W2890145654 modified "2023-10-06" @default.
• W2890145654 title "NK1.1 Expression Defines a Population of CD4+ Effector T Cells Displaying Th1 and Tfh Cell Properties That Support Early Antibody Production During Plasmodium yoelii Infection" @default.
• W2890145654 cites W1242484266 @default.
• W2890145654 cites W1538172952 @default.
• W2890145654 cites W1568984819 @default.
• W2890145654 cites W1779362169 @default.
• W2890145654 cites W1899957715 @default.
• W2890145654 cites W1934310819 @default.
• W2890145654 cites W1972579008 @default.
• W2890145654 cites W1975183474 @default.
• W2890145654 cites W1978564070 @default.
• W2890145654 cites W1987076250 @default.
• W2890145654 cites W1991709065 @default.
• W2890145654 cites W1995887899 @default.
• W2890145654 cites W2008317976 @default.
• W2890145654 cites W2030224128 @default.
• W2890145654 cites W2048651265 @default.
• W2890145654 cites W2060513670 @default.
• W2890145654 cites W2062533437 @default.
• W2890145654 cites W2066489069 @default.
• W2890145654 cites W2081276932 @default.
• W2890145654 cites W2085117860 @default.
• W2890145654 cites W2086770453 @default.
• W2890145654 cites W2093468604 @default.
• W2890145654 cites W2107564997 @default.
• W2890145654 cites W2112806823 @default.
• W2890145654 cites W2121477549 @default.
• W2890145654 cites W2125748342 @default.
• W2890145654 cites W2127474550 @default.
• W2890145654 cites W2130506153 @default.
• W2890145654 cites W2133945584 @default.
• W2890145654 cites W2164359892 @default.
• W2890145654 cites W2181213627 @default.
• W2890145654 cites W2196170761 @default.
• W2890145654 cites W2199086650 @default.
• W2890145654 cites W2206694007 @default.
• W2890145654 cites W2259408979 @default.
• W2890145654 cites W2403082333 @default.
• W2890145654 cites W2493524203 @default.
• W2890145654 cites W2594807826 @default.
• W2890145654 cites W2769184350 @default.
• W2890145654 cites W2790190789 @default.
• W2890145654 doi "https://doi.org/10.3389/fimmu.2018.02277" @default.
• W2890145654 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6196288" @default.
• W2890145654 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30374346" @default.
• W2890145654 hasPublicationYear "2018" @default.
• W2890145654 type Work @default.
• W2890145654 sameAs 2890145654 @default.
• W2890145654 citedByCount "13" @default.
• W2890145654 countsByYear W28901456542019 @default.
• W2890145654 countsByYear W28901456542020 @default.
• W2890145654 countsByYear W28901456542021 @default.
• W2890145654 countsByYear W28901456542022 @default.
• W2890145654 crossrefType "journal-article" @default.
• W2890145654 hasAuthorship W2890145654A5003558705 @default.
• W2890145654 hasAuthorship W2890145654A5026529034 @default.
• W2890145654 hasAuthorship W2890145654A5043321954 @default.
• W2890145654 hasAuthorship W2890145654A5066445201 @default.
• W2890145654 hasBestOaLocation W28901456541 @default.
• W2890145654 hasConcept C129374314 @default.
• W2890145654 hasConcept C139563560 @default.
• W2890145654 hasConcept C159654299 @default.
• W2890145654 hasConcept C203014093 @default.
• W2890145654 hasConcept C2775867548 @default.
• W2890145654 hasConcept C2776090121 @default.
• W2890145654 hasConcept C2776486806 @default.
• W2890145654 hasConcept C2778048844 @default.
• W2890145654 hasConcept C2778371730 @default.
• W2890145654 hasConcept C2908647359 @default.
• W2890145654 hasConcept C71924100 @default.
• W2890145654 hasConcept C86803240 @default.
• W2890145654 hasConcept C8891405 @default.
• W2890145654 hasConcept C95444343 @default.
• W2890145654 hasConcept C99454951 @default.
• W2890145654 hasConceptScore W2890145654C129374314 @default.
• W2890145654 hasConceptScore W2890145654C139563560 @default.
• W2890145654 hasConceptScore W2890145654C159654299 @default.
• W2890145654 hasConceptScore W2890145654C203014093 @default.
• W2890145654 hasConceptScore W2890145654C2775867548 @default.
• W2890145654 hasConceptScore W2890145654C2776090121 @default.
• W2890145654 hasConceptScore W2890145654C2776486806 @default.
• W2890145654 hasConceptScore W2890145654C2778048844 @default.
• W2890145654 hasConceptScore W2890145654C2778371730 @default.
• W2890145654 hasConceptScore W2890145654C2908647359 @default.
• W2890145654 hasConceptScore W2890145654C71924100 @default.
• W2890145654 hasConceptScore W2890145654C86803240 @default.
• W2890145654 hasConceptScore W2890145654C8891405 @default.
• W2890145654 hasConceptScore W2890145654C95444343 @default.
• W2890145654 hasConceptScore W2890145654C99454951 @default.
• W2890145654 hasLocation W28901456541 @default.
• W2890145654 hasLocation W28901456542 @default.
• W2890145654 hasLocation W28901456543 @default.
• W2890145654 hasLocation W28901456544 @default.

• next