Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890145824> ?p ?o ?g. }
- W2890145824 endingPage "1146" @default.
- W2890145824 startingPage "1134" @default.
- W2890145824 abstract "Loss of voice after vocal fold resection due to laryngeal cancer is a significant problem resulting in a low quality of life. Although there were many attempts to achieve a functional restoration of voice, challenges to regenerate vocal fold still remain due to its unique tissue mechanical characteristics such as pliability that produces phonation via vibration. In this study, we developed a mechanically compliant interpenetrating polymer network (IPN) hydrogel based on polyacrylamide (PAAM) and gelatin that matches physical and functional properties with native vocal fold tissue. The mechanical properties of this PAAM/gelatin (PG) hydrogel were optimized to have an elastic modulus of 5.4 kPa by adjusting the PAAM/gelatin ratio. In addition, the PG hydrogel demonstrated a minimal foreign body reaction upon implantation, and the hydrogel displayed a strong resistance to dehydration conditions that can last 40 days in the chamber with 60% humidity. Furthermore, the PG hydrogel demonstrated a self-healing ability that may allow ad-hoc implant augmentation. In addition, tough adhesion of the PG hydrogel resulted in stable attachment to vocal fold tissues. Finally, we demonstrated the functional restoration of voice on an ex vivo canine model by implanting the PG hydrogel as an artificial vocal fold tissue." @default.
- W2890145824 created "2018-09-27" @default.
- W2890145824 creator A5022972880 @default.
- W2890145824 creator A5054042232 @default.
- W2890145824 creator A5057083703 @default.
- W2890145824 creator A5058563246 @default.
- W2890145824 creator A5066677695 @default.
- W2890145824 creator A5068744299 @default.
- W2890145824 creator A5069034384 @default.
- W2890145824 creator A5070464282 @default.
- W2890145824 creator A5075710060 @default.
- W2890145824 creator A5086648710 @default.
- W2890145824 date "2018-09-18" @default.
- W2890145824 modified "2023-10-03" @default.
- W2890145824 title "Self-Healing and Adhesive Artificial Tissue Implant for Voice Recovery" @default.
- W2890145824 cites W1590149820 @default.
- W2890145824 cites W1967414236 @default.
- W2890145824 cites W1972674189 @default.
- W2890145824 cites W1975125896 @default.
- W2890145824 cites W1983586083 @default.
- W2890145824 cites W1987652134 @default.
- W2890145824 cites W1989019336 @default.
- W2890145824 cites W1994923832 @default.
- W2890145824 cites W2003805337 @default.
- W2890145824 cites W2007285097 @default.
- W2890145824 cites W2008803919 @default.
- W2890145824 cites W2017994314 @default.
- W2890145824 cites W2024306244 @default.
- W2890145824 cites W2025855717 @default.
- W2890145824 cites W2026250823 @default.
- W2890145824 cites W2027367352 @default.
- W2890145824 cites W2027827526 @default.
- W2890145824 cites W2029610785 @default.
- W2890145824 cites W2030842925 @default.
- W2890145824 cites W2032189819 @default.
- W2890145824 cites W2034756818 @default.
- W2890145824 cites W2036075940 @default.
- W2890145824 cites W2041778522 @default.
- W2890145824 cites W2043393623 @default.
- W2890145824 cites W2047502505 @default.
- W2890145824 cites W2052068800 @default.
- W2890145824 cites W2054252706 @default.
- W2890145824 cites W2054630868 @default.
- W2890145824 cites W2058786215 @default.
- W2890145824 cites W2060449729 @default.
- W2890145824 cites W2063851468 @default.
- W2890145824 cites W2069462618 @default.
- W2890145824 cites W2072079328 @default.
- W2890145824 cites W2073525902 @default.
- W2890145824 cites W2082110369 @default.
- W2890145824 cites W2083514344 @default.
- W2890145824 cites W2084742032 @default.
- W2890145824 cites W2105176080 @default.
- W2890145824 cites W2113650738 @default.
- W2890145824 cites W2116780622 @default.
- W2890145824 cites W2132119859 @default.
- W2890145824 cites W2134837906 @default.
- W2890145824 cites W2139966914 @default.
- W2890145824 cites W2141362699 @default.
- W2890145824 cites W2150757642 @default.
- W2890145824 cites W2163733857 @default.
- W2890145824 cites W2170927693 @default.
- W2890145824 cites W2195168232 @default.
- W2890145824 cites W2226772552 @default.
- W2890145824 cites W2228457042 @default.
- W2890145824 cites W2317069713 @default.
- W2890145824 cites W2337807063 @default.
- W2890145824 cites W2343461290 @default.
- W2890145824 cites W2414272621 @default.
- W2890145824 cites W2484267660 @default.
- W2890145824 cites W2509730992 @default.
- W2890145824 cites W2603044084 @default.
- W2890145824 cites W2607252873 @default.
- W2890145824 cites W2611604513 @default.
- W2890145824 cites W2736513744 @default.
- W2890145824 cites W2740710461 @default.
- W2890145824 cites W2754893103 @default.
- W2890145824 cites W2754965656 @default.
- W2890145824 cites W2760863103 @default.
- W2890145824 cites W2781760988 @default.
- W2890145824 cites W2799655126 @default.
- W2890145824 cites W2885676022 @default.
- W2890145824 cites W2006046745 @default.
- W2890145824 cites W2431618330 @default.
- W2890145824 doi "https://doi.org/10.1021/acsabm.8b00349" @default.
- W2890145824 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34996154" @default.
- W2890145824 hasPublicationYear "2018" @default.
- W2890145824 type Work @default.
- W2890145824 sameAs 2890145824 @default.
- W2890145824 citedByCount "18" @default.
- W2890145824 countsByYear W28901458242019 @default.
- W2890145824 countsByYear W28901458242020 @default.
- W2890145824 countsByYear W28901458242021 @default.
- W2890145824 countsByYear W28901458242022 @default.
- W2890145824 countsByYear W28901458242023 @default.
- W2890145824 crossrefType "journal-article" @default.
- W2890145824 hasAuthorship W2890145824A5022972880 @default.
- W2890145824 hasAuthorship W2890145824A5054042232 @default.