Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890145919> ?p ?o ?g. }
- W2890145919 abstract "Abstract Leucine-rich repeat transmembrane neuronal proteins (LRRTMs) function as postsynaptic organizers that induce excitatory synapses. Neurexins (Nrxns) and heparan sulfate proteoglycans have been identified as presynaptic ligands for LRRTMs. Specifically, LRRTM1 and LRRTM2 bind to the Nrxn splice variant lacking an insert at the splice site 4 (S4). Here, we report the crystal structure of the Nrxn1β–LRRTM2 complex at 3.4 Å resolution. The Nrxn1β–LRRTM2 interface involves Ca 2+ -mediated interactions and overlaps with the Nrxn–neuroligin interface. Together with structure-based mutational analyses at the molecular and cellular levels, the present structural analysis unveils the mechanism of selective binding between Nrxn and LRRTM1/2 and its modulation by the S4 insertion of Nrxn." @default.
- W2890145919 created "2018-09-27" @default.
- W2890145919 creator A5010981727 @default.
- W2890145919 creator A5017708258 @default.
- W2890145919 creator A5017811687 @default.
- W2890145919 creator A5018022829 @default.
- W2890145919 creator A5032226849 @default.
- W2890145919 creator A5039142113 @default.
- W2890145919 creator A5042597121 @default.
- W2890145919 creator A5052407958 @default.
- W2890145919 creator A5054944847 @default.
- W2890145919 creator A5060512272 @default.
- W2890145919 creator A5067152637 @default.
- W2890145919 creator A5085747078 @default.
- W2890145919 date "2018-09-27" @default.
- W2890145919 modified "2023-10-16" @default.
- W2890145919 title "Structural insights into modulation and selectivity of transsynaptic neurexin–LRRTM interaction" @default.
- W2890145919 cites W1491610362 @default.
- W2890145919 cites W1539796472 @default.
- W2890145919 cites W1561162876 @default.
- W2890145919 cites W1591227812 @default.
- W2890145919 cites W1966078827 @default.
- W2890145919 cites W1966277592 @default.
- W2890145919 cites W1968912036 @default.
- W2890145919 cites W1976499671 @default.
- W2890145919 cites W1976786580 @default.
- W2890145919 cites W1990122129 @default.
- W2890145919 cites W1992603916 @default.
- W2890145919 cites W2016441660 @default.
- W2890145919 cites W2024301757 @default.
- W2890145919 cites W2026381557 @default.
- W2890145919 cites W2030329464 @default.
- W2890145919 cites W2035266068 @default.
- W2890145919 cites W2035503835 @default.
- W2890145919 cites W2035687084 @default.
- W2890145919 cites W2047505167 @default.
- W2890145919 cites W2057477511 @default.
- W2890145919 cites W2057569198 @default.
- W2890145919 cites W2059013803 @default.
- W2890145919 cites W2064352628 @default.
- W2890145919 cites W2067174909 @default.
- W2890145919 cites W2072355028 @default.
- W2890145919 cites W2076977967 @default.
- W2890145919 cites W2082846873 @default.
- W2890145919 cites W2083254788 @default.
- W2890145919 cites W2097493124 @default.
- W2890145919 cites W2099540110 @default.
- W2890145919 cites W2108921801 @default.
- W2890145919 cites W2124032631 @default.
- W2890145919 cites W2128572087 @default.
- W2890145919 cites W2134984452 @default.
- W2890145919 cites W2139871765 @default.
- W2890145919 cites W2142368344 @default.
- W2890145919 cites W2144081223 @default.
- W2890145919 cites W2150909590 @default.
- W2890145919 cites W2154714625 @default.
- W2890145919 cites W2158476633 @default.
- W2890145919 cites W2163341755 @default.
- W2890145919 cites W2165918134 @default.
- W2890145919 cites W2233463338 @default.
- W2890145919 cites W2244257221 @default.
- W2890145919 cites W2303685484 @default.
- W2890145919 cites W2404280981 @default.
- W2890145919 cites W2408930580 @default.
- W2890145919 cites W2548396598 @default.
- W2890145919 cites W2748248568 @default.
- W2890145919 cites W2762342558 @default.
- W2890145919 cites W2765792294 @default.
- W2890145919 cites W2783071777 @default.
- W2890145919 cites W2783190507 @default.
- W2890145919 cites W4235774781 @default.
- W2890145919 doi "https://doi.org/10.1038/s41467-018-06333-8" @default.
- W2890145919 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6160412" @default.
- W2890145919 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30262834" @default.
- W2890145919 hasPublicationYear "2018" @default.
- W2890145919 type Work @default.
- W2890145919 sameAs 2890145919 @default.
- W2890145919 citedByCount "28" @default.
- W2890145919 countsByYear W28901459192019 @default.
- W2890145919 countsByYear W28901459192020 @default.
- W2890145919 countsByYear W28901459192021 @default.
- W2890145919 countsByYear W28901459192022 @default.
- W2890145919 crossrefType "journal-article" @default.
- W2890145919 hasAuthorship W2890145919A5010981727 @default.
- W2890145919 hasAuthorship W2890145919A5017708258 @default.
- W2890145919 hasAuthorship W2890145919A5017811687 @default.
- W2890145919 hasAuthorship W2890145919A5018022829 @default.
- W2890145919 hasAuthorship W2890145919A5032226849 @default.
- W2890145919 hasAuthorship W2890145919A5039142113 @default.
- W2890145919 hasAuthorship W2890145919A5042597121 @default.
- W2890145919 hasAuthorship W2890145919A5052407958 @default.
- W2890145919 hasAuthorship W2890145919A5054944847 @default.
- W2890145919 hasAuthorship W2890145919A5060512272 @default.
- W2890145919 hasAuthorship W2890145919A5067152637 @default.
- W2890145919 hasAuthorship W2890145919A5085747078 @default.
- W2890145919 hasBestOaLocation W28901459191 @default.
- W2890145919 hasConcept C104317684 @default.
- W2890145919 hasConcept C112592302 @default.
- W2890145919 hasConcept C12554922 @default.
- W2890145919 hasConcept C170493617 @default.