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- W2890147164 endingPage "1613" @default.
- W2890147164 startingPage "1605" @default.
- W2890147164 abstract "Psoriasis vulgaris is a common, heterogeneous, chronic inflammatory skin disease characterized by thickened, red, scaly plaques and systemic inflammation. Psoriasis is also associated with multiple comorbid conditions, such as joint destruction, cardiovascular disease, stroke, hypertension, metabolic syndrome, and chronic kidney disease. The discovery of IL-17-producing T cells in a mouse model of autoimmunity transformed our understanding of inflammation driven by T lymphocytes and associations with human inflammatory diseases, such as psoriasis. Under the regulation of IL-23, T cells that produce high levels of IL-17 create a self-amplifying, feed-forward inflammatory response in keratinocytes that drives the development of thickened skin lesions infiltrated with a mixture of inflammatory cell populations. Recently, the Food and Drug Administration approved multiple highly effective psoriasis therapies that disrupt IL-17 (secukinumab, ixekizumab, and brodalumab) and IL-23 (guselkumab and tildrakizumab) signaling in the skin, thus leading to a major paradigm shift in the way that psoriatic disease is managed." @default.
- W2890147164 created "2018-09-27" @default.
- W2890147164 creator A5011050088 @default.
- W2890147164 creator A5057861094 @default.
- W2890147164 creator A5065344066 @default.
- W2890147164 creator A5080337749 @default.
- W2890147164 date "2018-09-04" @default.
- W2890147164 modified "2023-10-16" @default.
- W2890147164 title "Discovery of the IL-23/IL-17 Signaling Pathway and the Treatment of Psoriasis" @default.
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- W2890147164 doi "https://doi.org/10.4049/jimmunol.1800013" @default.