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• W2890149467 endingPage "4397" @default.
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• W2890149467 abstract "Background and Purpose NMDA receptors play a key role in both synaptic plasticity and neurodegeneration. Adenosine is an endogenous neuromodulator and through membrane receptors of the A2A subtype can influence both synaptic plasticity and neuronal death. The present work was designed to evaluate the influence of adenosine A2A receptors upon NMDA receptor activity in CA1 hippocampal neurons. We discriminated between modulation of synaptic versus extrasynaptic receptors, since extrasynaptic NMDA receptors are mostly associated with neurodegeneration while synaptic NMDA receptors are linked to plasticity phenomena. Experimental Approach Whole-cell patch-clamp recordings were obtained to evaluate NMDA receptor actions on CA1 pyramidal neurons of young adult (5–10 weeks) male Wistar rat hippocampus. Key Results Activation of A2A receptors with CGS 21680 (30 nM) consistently facilitated chemically-evoked NMDA receptor-currents (NMDA-PSCs) and afferent-evoked NMDA-currents (NMDA-EPSCs), an action prevented by an A2A receptor antagonist (SCH58261, 100 nM) and a PKA inhibitor, H-89 (1 μM). These actions did not reflect facilitation in glutamate release since there was no change in NMDA-EPSCs paired pulse ratio. A2A receptor actions were lost in the presence of an open-channel NMDA receptor blocker, MK-801 (10 μM), but persisted in the presence of memantine, at a concentration (10 μM) known to preferentially block extrasynaptic NMDA receptors. Conclusion and Implications These results show that A2A receptors exert a positive postsynaptic modulatory effect over synaptic, but not extrasynaptic, NMDA receptors in CA1 neurons and, therefore, under non-pathological conditions may contribute to shift the dual role of NMDA receptors towards enhancement of synaptic plasticity." @default.
• W2890149467 created "2018-09-27" @default.
• W2890149467 creator A5021255614 @default.
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• W2890149467 date "2018-10-17" @default.
• W2890149467 modified "2023-10-17" @default.
• W2890149467 title "Adenosine A_2A receptors facilitate synaptic NMDA currents in CA1 pyramidal neurons" @default.
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• W2890149467 doi "https://doi.org/10.1111/bph.14497" @default.
• W2890149467 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6240125" @default.
• W2890149467 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30220081" @default.
• W2890149467 hasPublicationYear "2018" @default.
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