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- W2890151358 abstract "Abstract The E. coli MinCDE system has become a paradigmatic reaction–diffusion system in biology. The membrane-bound ATPase MinD and ATPase-activating protein MinE oscillate between the cell poles followed by MinC, thus positioning the main division protein FtsZ at midcell. Here we report that these energy-consuming MinDE oscillations may play a role beyond constraining MinC/FtsZ localization. Using an in vitro reconstitution assay, we show that MinDE self-organization can spatially regulate a variety of functionally completely unrelated membrane proteins into patterns and gradients. By concentration waves sweeping over the membrane, they induce a direct net transport of tightly membrane-attached molecules. That the MinDE system can spatiotemporally control a much larger set of proteins than previously known, may constitute a MinC-independent pathway to division site selection and chromosome segregation. Moreover, the here described phenomenon of active transport through a traveling diffusion barrier may point to a general mechanism of spatiotemporal regulation in cells." @default.
- W2890151358 created "2018-09-27" @default.
- W2890151358 creator A5009643453 @default.
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- W2890151358 date "2018-09-26" @default.
- W2890151358 modified "2023-10-14" @default.
- W2890151358 title "The MinDE system is a generic spatial cue for membrane protein distribution in vitro" @default.
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- W2890151358 doi "https://doi.org/10.1038/s41467-018-06310-1" @default.
- W2890151358 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6158289" @default.
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- W2890151358 hasPublicationYear "2018" @default.
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