FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890151582> ?p ?o ?g. }

• W2890151582 abstract "To comprehensively evaluate the diagnostic value of serum cartilage oligomeric matrix protein (COMP) and chondroitin sulfate 846 epitope (CS846) biomarkers in osteoarthritis (OA), longitudinal and combined measurement of serum COMP and CS846 were performed at different stages in the pathological process of OA in a rat model of anterior cruciate ligament transection (ACLT). Sixty male Sprague-Dawley rats were randomly divided into two groups, including a model group (n = 30) and a control group (n = 30). Rat models were established by ACLT surgery, and sham operations were performed on rats in the control group. Prior to surgery and at 2, 4, 6, 8, and 10 weeks after ACLT surgery, serum levels of COMP and CS846 biomarkers were determined using an enzyme-linked immunosorbent assay approach. Five rats per group were euthanized at 2, 4, 6, 8, and 10 weeks after surgery, after which tibial plateau specimens were collected. Macroscopic observation and histological examination were employed for rat tibial plateau. Histological changes in articular cartilage were evaluated according to Osteoarthritis Research Society International (OARSI) scoring criteria. The area under the curve (AUC) of COMP, CS846, and combined biomarkers was compared using receiver operating characteristic (ROC) curve. Within 10 weeks after surgery, serum levels of COMP and CS846 in the model group were significantly higher when compared to those in the control group. Moreover, a significant correlation was observed between changes in COMP and CS846 levels. At each time point, macroscopic observations and OARSI scores were significantly increased in the development of OA. The AUC of combined biomarkers was higher compared to that of COMP and CS846 alone. Finally, a positive relationship was found between levels of COMP and CS846 and the OARSI score. In this study, we found that combined detection of serum CS846 and COMP levels can be used for diagnosis and monitoring of OA progression." @default.
• W2890151582 created "2018-09-27" @default.
• W2890151582 creator A5009682806 @default.
• W2890151582 creator A5018177662 @default.
• W2890151582 creator A5018758426 @default.
• W2890151582 creator A5039266973 @default.
• W2890151582 creator A5039441880 @default.
• W2890151582 creator A5039600798 @default.
• W2890151582 creator A5044367029 @default.
• W2890151582 creator A5083516131 @default.
• W2890151582 creator A5085985102 @default.
• W2890151582 date "2018-09-12" @default.
• W2890151582 modified "2023-09-24" @default.
• W2890151582 title "Combined detection of COMP and CS846 biomarkers in experimental rat osteoarthritis: a potential approach for assessment and diagnosis of osteoarthritis" @default.
• W2890151582 cites W1778325192 @default.
• W2890151582 cites W1896156211 @default.
• W2890151582 cites W1985973049 @default.
• W2890151582 cites W1987754032 @default.
• W2890151582 cites W1992252990 @default.
• W2890151582 cites W1997386208 @default.
• W2890151582 cites W2007734100 @default.
• W2890151582 cites W2010294534 @default.
• W2890151582 cites W2016748229 @default.
• W2890151582 cites W2017553097 @default.
• W2890151582 cites W2026123588 @default.
• W2890151582 cites W2026574460 @default.
• W2890151582 cites W2027404394 @default.
• W2890151582 cites W2030483855 @default.
• W2890151582 cites W2073425477 @default.
• W2890151582 cites W2073708206 @default.
• W2890151582 cites W2073922218 @default.
• W2890151582 cites W2077835622 @default.
• W2890151582 cites W2099427592 @default.
• W2890151582 cites W2109441608 @default.
• W2890151582 cites W2114459121 @default.
• W2890151582 cites W2118536886 @default.
• W2890151582 cites W2123063562 @default.
• W2890151582 cites W2124783802 @default.
• W2890151582 cites W2140572743 @default.
• W2890151582 cites W2149895004 @default.
• W2890151582 cites W2152826176 @default.
• W2890151582 cites W2153673013 @default.
• W2890151582 cites W2167301035 @default.
• W2890151582 cites W2269139557 @default.
• W2890151582 cites W2290365287 @default.
• W2890151582 cites W2312615665 @default.
• W2890151582 cites W2313555702 @default.
• W2890151582 cites W2551320153 @default.
• W2890151582 cites W2623983122 @default.
• W2890151582 cites W2769437995 @default.
• W2890151582 cites W2789872440 @default.
• W2890151582 cites W2790013071 @default.
• W2890151582 cites W2793515649 @default.
• W2890151582 doi "https://doi.org/10.1186/s13018-018-0938-3" @default.
• W2890151582 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6134595" @default.
• W2890151582 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30208927" @default.
• W2890151582 hasPublicationYear "2018" @default.
• W2890151582 type Work @default.
• W2890151582 sameAs 2890151582 @default.
• W2890151582 citedByCount "18" @default.
• W2890151582 countsByYear W28901515822019 @default.
• W2890151582 countsByYear W28901515822020 @default.
• W2890151582 countsByYear W28901515822021 @default.
• W2890151582 countsByYear W28901515822022 @default.
• W2890151582 countsByYear W28901515822023 @default.
• W2890151582 crossrefType "journal-article" @default.
• W2890151582 hasAuthorship W2890151582A5009682806 @default.
• W2890151582 hasAuthorship W2890151582A5018177662 @default.
• W2890151582 hasAuthorship W2890151582A5018758426 @default.
• W2890151582 hasAuthorship W2890151582A5039266973 @default.
• W2890151582 hasAuthorship W2890151582A5039441880 @default.
• W2890151582 hasAuthorship W2890151582A5039600798 @default.
• W2890151582 hasAuthorship W2890151582A5044367029 @default.
• W2890151582 hasAuthorship W2890151582A5083516131 @default.
• W2890151582 hasAuthorship W2890151582A5085985102 @default.
• W2890151582 hasBestOaLocation W28901515821 @default.
• W2890151582 hasConcept C105702510 @default.
• W2890151582 hasConcept C10936531 @default.
• W2890151582 hasConcept C126322002 @default.
• W2890151582 hasConcept C126894567 @default.
• W2890151582 hasConcept C141071460 @default.
• W2890151582 hasConcept C142724271 @default.
• W2890151582 hasConcept C185592680 @default.
• W2890151582 hasConcept C198451711 @default.
• W2890151582 hasConcept C204787440 @default.
• W2890151582 hasConcept C2776164576 @default.
• W2890151582 hasConcept C2778232976 @default.
• W2890151582 hasConcept C2778384902 @default.
• W2890151582 hasConcept C2778434673 @default.
• W2890151582 hasConcept C2780550940 @default.
• W2890151582 hasConcept C2781197716 @default.
• W2890151582 hasConcept C55493867 @default.
• W2890151582 hasConcept C58471807 @default.
• W2890151582 hasConcept C68312169 @default.
• W2890151582 hasConcept C71924100 @default.
• W2890151582 hasConcept C76318530 @default.
• W2890151582 hasConcept C90924648 @default.
• W2890151582 hasConceptScore W2890151582C105702510 @default.
• W2890151582 hasConceptScore W2890151582C10936531 @default.
• W2890151582 hasConceptScore W2890151582C126322002 @default.

• next