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- W2890155941 abstract "Swelling of the optic nerve head (ONH) is most accurately quantitatively assessed via volumetric measures using 3D spectral-domain optical coherence tomography (SD-OCT). However, SD-OCT is not always available as its use is primarily limited to specialized eye clinics rather than in primary care or telemedical settings. Thus, there is still a need for severity assessment using more widely available 2D fundus photographs. In this work, we propose a machine-learning approach to locally estimate the degree of the optic disc swelling at each pixel location from only a 2D fundus photograph as the input. For training purposes, a thickness map of the swelling (reflecting the distance between the top and bottom surfaces of the ONH and surrounding retina) as measured from SD-OCT at each pixel location was used as the ground truth. A random-forest classifier was trained to output each thickness value from local fundus features pertaining to textural and color information. Eighty-eight image pairs of ONH-centered SD-OCT and registered fundus photographs from different subjects with optic disc swelling were used for training and evaluating the model in a leave-one-subject-out fashion. Comparing the thickness map from the proposed method to the ground truth via SD-OCT, a root-mean-square (RMS) error of 1.66 mm(^3) for the entire ONH region was achieved, and Spearman’s correlation coefficient was (R=0.73). Regional volumes for the nasal, temporal, inferior, superior, and peripapillary regions had RMS errors of 0.64 mm(^3), 0.61 mm(^3), 0.74 mm(^3), 0.71 mm(^3), and 1.30 mm(^3), respectively, suggesting that there is enough evidence in a singular color fundus photograph to estimate local swelling information." @default.
- W2890155941 created "2018-09-27" @default.
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- W2890155941 date "2018-01-01" @default.
- W2890155941 modified "2023-09-24" @default.
- W2890155941 title "Local Estimation of the Degree of Optic Disc Swelling from Color Fundus Photography" @default.
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- W2890155941 doi "https://doi.org/10.1007/978-3-030-00949-6_33" @default.
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