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- W2890156471 abstract "MR biomarkers have shown considerable promise as outcome measures in clinical trials for Duchenne muscular dystrophy (DMD). Imaging DMD has developed an extensive clinical trial network with an infrastructure that enables high quality MR data collection across centers. The infrastructure incorporates standardized acquisition procedures, efficient data management, automated processing of images and spectra as a pipeline, phantoms, and quality assurance procedures. MR procedures have been successfully implemented for measuring fat fraction (FF) by both magnetic resonance spectroscopy (1H-MRS) and Dixon imaging, as well as the MRI transverse relaxation time constant (T2), enabling cross validation among measures. In addition, we measure 1H2O T2 using single voxel 1H-MRS as a marker of membrane stability and inflammation. In this study, we describe the infrastructure and MR methods used in these studies, and compare the sensitivity of these measurements to disease progression in a range of lower extremity muscles and ages using data acquired at three centers using 3T MR systems in 138 individuals with DMD (8.8±3.3 years) and 51 unaffected controls (8.8±2.4 years). Our results show a range of involvement and disease progression among muscles, with each MR measure able to robustly discriminate unaffected controls and DMD (p<0.05). Furthermore, the MR measures of muscle FF and MRI T2 were all able to detect longitudinal changes within one year (p<0.05) in the soleus and vastus lateralis. Overall, the Imaging DMD Clinical Trial Network has successfully implemented standardized MR procedures over multiple sites, and presently includes 21 certified MR sites across North America and Europe." @default.
- W2890156471 created "2018-09-27" @default.
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- W2890156471 date "2018-10-01" @default.
- W2890156471 modified "2023-09-26" @default.
- W2890156471 title "DUCHENNE MUSCULAR DYSTROPHY – IMAGING AND BIOMARKERS" @default.
- W2890156471 doi "https://doi.org/10.1016/j.nmd.2018.06.062" @default.
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