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- W2890158083 endingPage "1325" @default.
- W2890158083 startingPage "1313" @default.
- W2890158083 abstract "Recent studies show that cancer cells are sometimes able to evade the host immunity in the tumor microenvironment. Cancer cells can express high levels of immune inhibitory signaling proteins. One of the most critical checkpoint pathways in this system is a tumor-induced immune suppression (immune checkpoint) mediated by the programmed cell death protein 1 (PD-1) and its ligand, programmed death ligand 1 (PD-L1). PD-1 is highly expressed by activated T cells, B cells, dendritic cells, and natural killer cells, whereas PD-L1 is expressed on several types of tumor cells. Many studies have shown that blocking the interaction between PD-1 and PD-L1 enhances the T-cell response and mediates antitumor activity. In this review, we highlight a brief overview of the molecular and biochemical events that are regulated by the PD-1 and PD-L1 interaction in various cancers." @default.
- W2890158083 created "2018-09-27" @default.
- W2890158083 creator A5008224528 @default.
- W2890158083 creator A5011775579 @default.
- W2890158083 creator A5047156513 @default.
- W2890158083 creator A5047935513 @default.
- W2890158083 creator A5060030481 @default.
- W2890158083 date "2018-09-07" @default.
- W2890158083 modified "2023-10-11" @default.
- W2890158083 title "PD‐1/PD‐L1 immune checkpoint: Potential target for cancer therapy" @default.
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