Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890158715> ?p ?o ?g. }
- W2890158715 endingPage "96" @default.
- W2890158715 startingPage "88" @default.
- W2890158715 abstract "Interleukin 7 (IL-7) and its receptor (IL-7R, a heterodimer of IL-7Rα and γc) are essential for normal lymphoid development. In their absence, severe combined immunodeficiency occurs. By contrast, excessive IL-7/IL-7R-mediated signaling can drive lymphoid leukemia development, disease acceleration and resistance to chemotherapy. IL-7 and IL-7R activate three main pathways: STAT5, PI3K/Akt/mTOR and MEK/Erk, ultimately leading to the promotion of leukemia cell viability, cell cycle progression and growth. However, the contribution of each of these pathways towards particular functional outcomes is still not completely known and appears to differ between normal and malignant states. For example, IL-7 upregulates Bcl-2 in a PI3K/Akt/mTOR-dependent and STAT5-independent manner in T-ALL cells. This is a ‘symmetric image’ of what apparently happens in normal lymphoid cells, where PI3K/Akt/mTOR does not impact on Bcl-2 and regulates proliferation rather than survival. In this review, we provide an updated summary of the knowledge on IL-7/IL-7R-mediated signaling in the context of cancer, focusing mainly on T-cell acute lymphoblastic leukemia, where this axis has been more extensively studied." @default.
- W2890158715 created "2018-09-27" @default.
- W2890158715 creator A5018541891 @default.
- W2890158715 creator A5031346752 @default.
- W2890158715 creator A5038469796 @default.
- W2890158715 creator A5056580072 @default.
- W2890158715 creator A5074420777 @default.
- W2890158715 date "2019-01-01" @default.
- W2890158715 modified "2023-10-16" @default.
- W2890158715 title "IL-7R-mediated signaling in T-cell acute lymphoblastic leukemia: An update" @default.
- W2890158715 cites W1493289946 @default.
- W2890158715 cites W1509163238 @default.
- W2890158715 cites W1576342294 @default.
- W2890158715 cites W1601504908 @default.
- W2890158715 cites W163953079 @default.
- W2890158715 cites W1932639671 @default.
- W2890158715 cites W1948212455 @default.
- W2890158715 cites W1960663070 @default.
- W2890158715 cites W1976171257 @default.
- W2890158715 cites W1976955442 @default.
- W2890158715 cites W1977696847 @default.
- W2890158715 cites W1977812814 @default.
- W2890158715 cites W1981217106 @default.
- W2890158715 cites W1986462796 @default.
- W2890158715 cites W1986740965 @default.
- W2890158715 cites W1987202994 @default.
- W2890158715 cites W1990606779 @default.
- W2890158715 cites W1993017155 @default.
- W2890158715 cites W1993897258 @default.
- W2890158715 cites W1994373739 @default.
- W2890158715 cites W1994568187 @default.
- W2890158715 cites W1994844769 @default.
- W2890158715 cites W1997003026 @default.
- W2890158715 cites W1997273043 @default.
- W2890158715 cites W2000266274 @default.
- W2890158715 cites W2000589976 @default.
- W2890158715 cites W2004017449 @default.
- W2890158715 cites W2004124297 @default.
- W2890158715 cites W2004714325 @default.
- W2890158715 cites W2004985492 @default.
- W2890158715 cites W2006455392 @default.
- W2890158715 cites W2009012723 @default.
- W2890158715 cites W2009596701 @default.
- W2890158715 cites W2010234200 @default.
- W2890158715 cites W2010639752 @default.
- W2890158715 cites W2010731453 @default.
- W2890158715 cites W2014889002 @default.
- W2890158715 cites W2019552337 @default.
- W2890158715 cites W2019898235 @default.
- W2890158715 cites W2024945535 @default.
- W2890158715 cites W2028637369 @default.
- W2890158715 cites W2034238101 @default.
- W2890158715 cites W2035434998 @default.
- W2890158715 cites W2039616075 @default.
- W2890158715 cites W2048591984 @default.
- W2890158715 cites W2048844541 @default.
- W2890158715 cites W2049014273 @default.
- W2890158715 cites W2052273633 @default.
- W2890158715 cites W2056376302 @default.
- W2890158715 cites W2057848328 @default.
- W2890158715 cites W2058971169 @default.
- W2890158715 cites W2060605982 @default.
- W2890158715 cites W2063462830 @default.
- W2890158715 cites W2067211970 @default.
- W2890158715 cites W2067416677 @default.
- W2890158715 cites W2069147821 @default.
- W2890158715 cites W2071359178 @default.
- W2890158715 cites W2072317518 @default.
- W2890158715 cites W2073694032 @default.
- W2890158715 cites W2073848442 @default.
- W2890158715 cites W2080051516 @default.
- W2890158715 cites W2080181628 @default.
- W2890158715 cites W2081474521 @default.
- W2890158715 cites W2083685529 @default.
- W2890158715 cites W2083691419 @default.
- W2890158715 cites W2084448746 @default.
- W2890158715 cites W2086354897 @default.
- W2890158715 cites W2089491301 @default.
- W2890158715 cites W2095308946 @default.
- W2890158715 cites W2096564447 @default.
- W2890158715 cites W2096632716 @default.
- W2890158715 cites W2096679660 @default.
- W2890158715 cites W2096885745 @default.
- W2890158715 cites W2101694534 @default.
- W2890158715 cites W2102369355 @default.
- W2890158715 cites W2102391679 @default.
- W2890158715 cites W2103420336 @default.
- W2890158715 cites W2103539973 @default.
- W2890158715 cites W2104299839 @default.
- W2890158715 cites W2114474071 @default.
- W2890158715 cites W2115508261 @default.
- W2890158715 cites W2118754985 @default.
- W2890158715 cites W2127036087 @default.
- W2890158715 cites W2129495397 @default.
- W2890158715 cites W2131607964 @default.
- W2890158715 cites W2132149459 @default.
- W2890158715 cites W2132921024 @default.
- W2890158715 cites W2135463621 @default.