Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890159577> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W2890159577 endingPage "S41" @default.
- W2890159577 startingPage "S41" @default.
- W2890159577 abstract "Background: Differences in clinical staging and survival rates between pancreatic head, body, and tail cancers have been suggested, but are not well defined. We aim to determine the prognostic relevance of tumor location in patients undergoing treatment for pancreatic ductal carcinoma (PDAC). Methods: The American College of Surgeons National Cancer Database was used to identify patients with PDAC from 1998 to 2011 (n = 175556). Patients were categorized according to primary tumor site into head (67.5%, n = 118343), body (15.5%, n = 27218), and tail (17.0%, n = 29885) groups. Univariate and Cox regression analyses were used to determine covariates associated with overall survival (OS). Results: Patients with PDAC of the head were found to present with earlier stage disease (39.2% Stage I/II vs. 19.7% vs. 16.0%, p < 0.01) and underwent surgical resection more often (16.7% vs. 8.2% vs. 13.4%, p < 0.01) than those with body or tail tumors. Of surgically resected PDAC tumors, however, those localized to the head were found to have more advanced pathologic stage (84.8% Stage II/III vs. 66.7% vs. 65.6%, p < 0.01), higher nodal positivity (64.9% vs. 45.8% vs. 45.0%, p < 0.01), and worse tumor grade (35.9% poorly differentiated vs. 29.5% vs. 27.8%, p < 0.01). Despite increased utilization of adjuvant therapies (54.5% vs. 45.6% vs. 42.0%, p < 0.01), patients with PDAC of the head suffered inferior OS compared to those with body and tail tumors (Figure, p < 0.01). Conclusion: Tumor localization to the head is associated with improved resectability for PDAC patients as they present at an earlier stage of disease. Of PDACs amenable to resection, however, those localized to the head experience worse overall survival compared to tumors of the body and tail. This discrepancy may represent lead time bias in diagnosis and selection of biology between tumor sites." @default.
- W2890159577 created "2018-09-27" @default.
- W2890159577 creator A5001355673 @default.
- W2890159577 creator A5016048932 @default.
- W2890159577 creator A5017257914 @default.
- W2890159577 creator A5018646441 @default.
- W2890159577 creator A5033322859 @default.
- W2890159577 creator A5034875555 @default.
- W2890159577 creator A5050899249 @default.
- W2890159577 creator A5069928879 @default.
- W2890159577 creator A5090712551 @default.
- W2890159577 date "2018-03-01" @default.
- W2890159577 modified "2023-09-26" @default.
- W2890159577 title "Impact of tumor location on resectability and survival for pancreatic ductal adenocarcinoma" @default.
- W2890159577 doi "https://doi.org/10.1016/j.hpb.2018.02.238" @default.
- W2890159577 hasPublicationYear "2018" @default.
- W2890159577 type Work @default.
- W2890159577 sameAs 2890159577 @default.
- W2890159577 citedByCount "0" @default.
- W2890159577 crossrefType "journal-article" @default.
- W2890159577 hasAuthorship W2890159577A5001355673 @default.
- W2890159577 hasAuthorship W2890159577A5016048932 @default.
- W2890159577 hasAuthorship W2890159577A5017257914 @default.
- W2890159577 hasAuthorship W2890159577A5018646441 @default.
- W2890159577 hasAuthorship W2890159577A5033322859 @default.
- W2890159577 hasAuthorship W2890159577A5034875555 @default.
- W2890159577 hasAuthorship W2890159577A5050899249 @default.
- W2890159577 hasAuthorship W2890159577A5069928879 @default.
- W2890159577 hasAuthorship W2890159577A5090712551 @default.
- W2890159577 hasBestOaLocation W28901595771 @default.
- W2890159577 hasConcept C121608353 @default.
- W2890159577 hasConcept C126322002 @default.
- W2890159577 hasConcept C143998085 @default.
- W2890159577 hasConcept C144301174 @default.
- W2890159577 hasConcept C146357865 @default.
- W2890159577 hasConcept C151730666 @default.
- W2890159577 hasConcept C2780210213 @default.
- W2890159577 hasConcept C2781182431 @default.
- W2890159577 hasConcept C2992026798 @default.
- W2890159577 hasConcept C38180746 @default.
- W2890159577 hasConcept C50382708 @default.
- W2890159577 hasConcept C71924100 @default.
- W2890159577 hasConcept C86803240 @default.
- W2890159577 hasConcept C90924648 @default.
- W2890159577 hasConceptScore W2890159577C121608353 @default.
- W2890159577 hasConceptScore W2890159577C126322002 @default.
- W2890159577 hasConceptScore W2890159577C143998085 @default.
- W2890159577 hasConceptScore W2890159577C144301174 @default.
- W2890159577 hasConceptScore W2890159577C146357865 @default.
- W2890159577 hasConceptScore W2890159577C151730666 @default.
- W2890159577 hasConceptScore W2890159577C2780210213 @default.
- W2890159577 hasConceptScore W2890159577C2781182431 @default.
- W2890159577 hasConceptScore W2890159577C2992026798 @default.
- W2890159577 hasConceptScore W2890159577C38180746 @default.
- W2890159577 hasConceptScore W2890159577C50382708 @default.
- W2890159577 hasConceptScore W2890159577C71924100 @default.
- W2890159577 hasConceptScore W2890159577C86803240 @default.
- W2890159577 hasConceptScore W2890159577C90924648 @default.
- W2890159577 hasLocation W28901595771 @default.
- W2890159577 hasOpenAccess W2890159577 @default.
- W2890159577 hasPrimaryLocation W28901595771 @default.
- W2890159577 hasRelatedWork W2080671488 @default.
- W2890159577 hasRelatedWork W2102245227 @default.
- W2890159577 hasRelatedWork W2510739444 @default.
- W2890159577 hasRelatedWork W2531714473 @default.
- W2890159577 hasRelatedWork W2791744033 @default.
- W2890159577 hasRelatedWork W2801241205 @default.
- W2890159577 hasRelatedWork W2902481227 @default.
- W2890159577 hasRelatedWork W2963199750 @default.
- W2890159577 hasRelatedWork W4286270419 @default.
- W2890159577 hasRelatedWork W4313646721 @default.
- W2890159577 hasVolume "20" @default.
- W2890159577 isParatext "false" @default.
- W2890159577 isRetracted "false" @default.
- W2890159577 magId "2890159577" @default.
- W2890159577 workType "article" @default.