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• W2890162413 endingPage "913" @default.
• W2890162413 startingPage "892" @default.
• W2890162413 abstract "Background Nonalcoholic fatty disease (NAFLD) is the most common liver disease, since it is strongly associated with obesity and metabolic syndrome pandemics. NAFLD may affect drug disposal and has common pathophysiological mechanisms with drug-induced liver injury (DILI); this may predispose to hepatoxicity induced by certain drugs that share these pathophysiological mechanisms. In addition, drugs may trigger fatty liver and inflammation per se by mimicking NAFLD pathophysiological mechanisms. Aims To provide a comprehensive update on (a) potential mechanisms whereby certain drugs can be more hepatotoxic in NAFLD patients, (b) the steatogenic effects of drugs, and (c) the mechanism involved in drug-induced steatohepatitis (DISH). Methods A language- and date-unrestricted Medline literature search was conducted to identify pertinent basic and clinical studies on the topic. Results Drugs can induce macrovesicular steatosis by mimicking NAFLD pathogenic factors, including insulin resistance and imbalance between fat gain and loss. Other forms of hepatic fat accumulation exist, such as microvesicular steatosis and phospholipidosis, and are mostly associated with acute mitochondrial dysfunction and defective lipophagy, respectively. Drug-induced mitochondrial dysfunction is also commonly involved in DISH. Patients with pre-existing NAFLD may be at higher risk of DILI induced by certain drugs, and polypharmacy in obese individuals to treat their comorbidities may be a contributing factor. Conclusions The relationship between DILI and NAFLD may be reciprocal: drugs can cause NAFLD by acting as steatogenic factors, and pre-existing NAFLD could be a predisposing condition for certain drugs to cause DILI. Polypharmacy associated with obesity might potentiate the association between this condition and DILI." @default.
• W2890162413 created "2018-09-27" @default.
• W2890162413 creator A5022632079 @default.
• W2890162413 creator A5034269872 @default.
• W2890162413 creator A5066387396 @default.
• W2890162413 creator A5071944752 @default.
• W2890162413 creator A5084547712 @default.
• W2890162413 date "2018-09-07" @default.
• W2890162413 modified "2023-10-08" @default.
• W2890162413 title "Review article: drug-induced liver injury in the context of nonalcoholic fatty liver disease - a physiopathological and clinical integrated view" @default.
• W2890162413 cites W11060070 @default.
• W2890162413 cites W111279876 @default.
• W2890162413 cites W1256659649 @default.
• W2890162413 cites W1495541129 @default.
• W2890162413 cites W1511494417 @default.
• W2890162413 cites W1578683055 @default.
• W2890162413 cites W1581115144 @default.
• W2890162413 cites W1593901930 @default.
• W2890162413 cites W1595565189 @default.
• W2890162413 cites W1622799587 @default.
• W2890162413 cites W1749819217 @default.
• W2890162413 cites W1750163983 @default.
• W2890162413 cites W1795186414 @default.
• W2890162413 cites W1824483124 @default.
• W2890162413 cites W1831268717 @default.
• W2890162413 cites W1845024025 @default.
• W2890162413 cites W1909437153 @default.
• W2890162413 cites W1963673812 @default.
• W2890162413 cites W1964624702 @default.
• W2890162413 cites W1967346213 @default.
• W2890162413 cites W1967522801 @default.
• W2890162413 cites W1967554392 @default.
• W2890162413 cites W1967688734 @default.
• W2890162413 cites W1967972402 @default.
• W2890162413 cites W1968447063 @default.
• W2890162413 cites W1968940692 @default.
• W2890162413 cites W1969023742 @default.
• W2890162413 cites W1970761373 @default.
• W2890162413 cites W1970781279 @default.
• W2890162413 cites W1971042451 @default.
• W2890162413 cites W1971554083 @default.
• W2890162413 cites W1972050244 @default.
• W2890162413 cites W1972555033 @default.
• W2890162413 cites W1974436444 @default.
• W2890162413 cites W1974719515 @default.
• W2890162413 cites W1975053453 @default.
• W2890162413 cites W1975303104 @default.
• W2890162413 cites W1975437503 @default.
• W2890162413 cites W1976305587 @default.
• W2890162413 cites W1976313883 @default.
• W2890162413 cites W1976717494 @default.
• W2890162413 cites W1976740634 @default.
• W2890162413 cites W1976860473 @default.
• W2890162413 cites W1978045299 @default.
• W2890162413 cites W1978988408 @default.
• W2890162413 cites W1978998408 @default.
• W2890162413 cites W1979157320 @default.
• W2890162413 cites W1979283297 @default.
• W2890162413 cites W1979571494 @default.
• W2890162413 cites W1979899357 @default.
• W2890162413 cites W1980050556 @default.
• W2890162413 cites W1980377432 @default.
• W2890162413 cites W1980726398 @default.
• W2890162413 cites W1981018347 @default.
• W2890162413 cites W1981956617 @default.
• W2890162413 cites W1982168327 @default.
• W2890162413 cites W1984077928 @default.
• W2890162413 cites W1984393514 @default.
• W2890162413 cites W1985236262 @default.
• W2890162413 cites W1985592156 @default.
• W2890162413 cites W1986918553 @default.
• W2890162413 cites W1987340238 @default.
• W2890162413 cites W1987396009 @default.
• W2890162413 cites W1988345602 @default.
• W2890162413 cites W1988407600 @default.
• W2890162413 cites W1990190168 @default.
• W2890162413 cites W1991821243 @default.
• W2890162413 cites W1993336886 @default.
• W2890162413 cites W1993384072 @default.
• W2890162413 cites W1993458861 @default.
• W2890162413 cites W1994905881 @default.
• W2890162413 cites W1995000970 @default.
• W2890162413 cites W1996907401 @default.
• W2890162413 cites W1997188685 @default.
• W2890162413 cites W1997317586 @default.
• W2890162413 cites W1997357473 @default.
• W2890162413 cites W1997489624 @default.
• W2890162413 cites W1998784532 @default.
• W2890162413 cites W1999302803 @default.
• W2890162413 cites W2001682599 @default.
• W2890162413 cites W2001718707 @default.
• W2890162413 cites W2003659035 @default.
• W2890162413 cites W2004160850 @default.
• W2890162413 cites W2005771272 @default.
• W2890162413 cites W2006216450 @default.
• W2890162413 cites W2006334817 @default.
• W2890162413 cites W2006826612 @default.
• W2890162413 cites W2007505836 @default.

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