Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890165920> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W2890165920 endingPage "2009" @default.
- W2890165920 startingPage "2006" @default.
- W2890165920 abstract "Background: Certain molecular deviations can lead to the development of breast cancer. For instance, estrogen and estrogen receptors play a significant role in inducing tumor proliferation. However, the efficacy of endocrine therapy through the administration of anti-estrogen drugs, such as Tamoxifen, is challenged by acquired resistance. Methods: Relevant articles were retrieved from Medline and google scholar. All were screened to select the ones discussing the molecular mechanisms of angiogenesis and Tamoxifen resistance. The molecular interactions contributing in the resistant network were studied from the eligible articles. Results: Tamoxifen resistance occurs as a consequence of over-activated signal transduction pathways such as RTK s dependent cascades. It has been shown that microvessel count was greater in Tamoxifen resistant tissues than in responsive ones. Conclusion: In this review, the interaction between estrogen, Tamoxifen, VEGF, and VEGF receptors (VEGFRs) in Tamoxifen resistant cells has been discussed. VEGF and estrogen-independent growth cascades, especially MAPK have a positive feedback loop in Tamoxifen resistant cells. It has been proposed that over-activated pathways in Tamoxifen resistant cells induce pin1 mediated VEGF over-expression, which in turn result in enhanced activation of MAPK." @default.
- W2890165920 created "2018-09-27" @default.
- W2890165920 creator A5019787063 @default.
- W2890165920 creator A5020076589 @default.
- W2890165920 creator A5026819094 @default.
- W2890165920 creator A5039487112 @default.
- W2890165920 creator A5071232185 @default.
- W2890165920 date "2019-02-15" @default.
- W2890165920 modified "2023-10-14" @default.
- W2890165920 title "A Review on The Role of VEGF in Tamoxifen Resistance" @default.
- W2890165920 doi "https://doi.org/10.2174/1871520618666180911142259" @default.
- W2890165920 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30207246" @default.
- W2890165920 hasPublicationYear "2019" @default.
- W2890165920 type Work @default.
- W2890165920 sameAs 2890165920 @default.
- W2890165920 citedByCount "7" @default.
- W2890165920 countsByYear W28901659202020 @default.
- W2890165920 countsByYear W28901659202021 @default.
- W2890165920 countsByYear W28901659202022 @default.
- W2890165920 crossrefType "journal-article" @default.
- W2890165920 hasAuthorship W2890165920A5019787063 @default.
- W2890165920 hasAuthorship W2890165920A5020076589 @default.
- W2890165920 hasAuthorship W2890165920A5026819094 @default.
- W2890165920 hasAuthorship W2890165920A5039487112 @default.
- W2890165920 hasAuthorship W2890165920A5071232185 @default.
- W2890165920 hasConcept C121608353 @default.
- W2890165920 hasConcept C126322002 @default.
- W2890165920 hasConcept C134018914 @default.
- W2890165920 hasConcept C143998085 @default.
- W2890165920 hasConcept C167734588 @default.
- W2890165920 hasConcept C2777025900 @default.
- W2890165920 hasConcept C2777164284 @default.
- W2890165920 hasConcept C2777176818 @default.
- W2890165920 hasConcept C2780394083 @default.
- W2890165920 hasConcept C502942594 @default.
- W2890165920 hasConcept C530470458 @default.
- W2890165920 hasConcept C57074206 @default.
- W2890165920 hasConcept C60644358 @default.
- W2890165920 hasConcept C62478195 @default.
- W2890165920 hasConcept C71924100 @default.
- W2890165920 hasConcept C84606932 @default.
- W2890165920 hasConcept C86803240 @default.
- W2890165920 hasConcept C95444343 @default.
- W2890165920 hasConcept C98274493 @default.
- W2890165920 hasConceptScore W2890165920C121608353 @default.
- W2890165920 hasConceptScore W2890165920C126322002 @default.
- W2890165920 hasConceptScore W2890165920C134018914 @default.
- W2890165920 hasConceptScore W2890165920C143998085 @default.
- W2890165920 hasConceptScore W2890165920C167734588 @default.
- W2890165920 hasConceptScore W2890165920C2777025900 @default.
- W2890165920 hasConceptScore W2890165920C2777164284 @default.
- W2890165920 hasConceptScore W2890165920C2777176818 @default.
- W2890165920 hasConceptScore W2890165920C2780394083 @default.
- W2890165920 hasConceptScore W2890165920C502942594 @default.
- W2890165920 hasConceptScore W2890165920C530470458 @default.
- W2890165920 hasConceptScore W2890165920C57074206 @default.
- W2890165920 hasConceptScore W2890165920C60644358 @default.
- W2890165920 hasConceptScore W2890165920C62478195 @default.
- W2890165920 hasConceptScore W2890165920C71924100 @default.
- W2890165920 hasConceptScore W2890165920C84606932 @default.
- W2890165920 hasConceptScore W2890165920C86803240 @default.
- W2890165920 hasConceptScore W2890165920C95444343 @default.
- W2890165920 hasConceptScore W2890165920C98274493 @default.
- W2890165920 hasIssue "14" @default.
- W2890165920 hasLocation W28901659201 @default.
- W2890165920 hasLocation W28901659202 @default.
- W2890165920 hasOpenAccess W2890165920 @default.
- W2890165920 hasPrimaryLocation W28901659201 @default.
- W2890165920 hasRelatedWork W1982850748 @default.
- W2890165920 hasRelatedWork W200925908 @default.
- W2890165920 hasRelatedWork W2034033931 @default.
- W2890165920 hasRelatedWork W2087504465 @default.
- W2890165920 hasRelatedWork W2117019370 @default.
- W2890165920 hasRelatedWork W2335928397 @default.
- W2890165920 hasRelatedWork W2364285896 @default.
- W2890165920 hasRelatedWork W3010551324 @default.
- W2890165920 hasRelatedWork W3209895153 @default.
- W2890165920 hasRelatedWork W4252776767 @default.
- W2890165920 hasVolume "18" @default.
- W2890165920 isParatext "false" @default.
- W2890165920 isRetracted "false" @default.
- W2890165920 magId "2890165920" @default.
- W2890165920 workType "article" @default.