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• W2890166059 abstract "Numerous studies have reported that the glycaemic response to starch-rich meals can be reduced by 20-50% with acidic drinks or foods. A number of candidate explanations have been put forward, but this phenomenon still remains vaguely understood. This study intends to demonstrate the remarkable effect of acid inhibition of salivary α-amylase during oro-gastric hydrolysis of starch, shedding light on this often overlooked mechanism. Oro-gastric digestions of bread, wheat and gluten-free pastas, combined with either water or lemon juice were performed using a dynamic in vitro system that reproduces gastric acidification kinetics observed in humans. In the presence of water, large proportions of starch (25-85%) and oligosaccharides (15-50%) were released from all foods within the first hour of gastric digestion (pH > 3.5). In the presence of lemon juice (pH < 3.5 at all time), starch release was about twice as low, and amylolysis into oligosaccharides was completely interrupted. Acid-inhibition of salivary α-amylase may explain, at least in part, the reduction of the blood glucose response through acidification of starch-rich foods/meals. This offers new perspectives for the development of strategies to improve the glycaemic response elicited by starch-rich diets." @default.
• W2890166059 created "2018-09-27" @default.
• W2890166059 creator A5035426520 @default.
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• W2890166059 date "2018-01-01" @default.
• W2890166059 modified "2023-09-25" @default.
• W2890166059 title "Acid induced reduction of the glycaemic response to starch-rich foods: the salivary α-amylase inhibition hypothesis" @default.
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• W2890166059 doi "https://doi.org/10.1039/c8fo01489b" @default.
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