FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890166307> ?p ?o ?g. }

• W2890166307 abstract "Autism spectrum disorders (ASD) are a complex group of neurodevelopmental disorders with a genetic basis. The role of long-chain polyunsaturated fatty acids (LC-PUFAs) and the occurrence of autism has been the focus of many recent studies. The present study investigates whether genetic variants of the fatty acid desaturase (FADS) 1/2 and elongation of very long-chain fatty acids protein (ELOVL) 2 genes, which are involved in LC-PUFA metabolism, are associated with ASD risk. A cohort of 243 ASD patients and 243 unrelated healthy controls were enrolled in this case control study. Sixteen tag single nucleotide polymorphisms from the FADS1–2 and ELOVL2 genes were genotyped using the Sequenom Mass Array. There were significant differences in allelic distribution of FADS2 rs526126 (OR = 0.55, 95% CI = 0.42–0.72, pFDR < 0.05) between autistic children and controls. FADS2 rs526126 and ELOVL2 rs10498676 were associated with decreased ASD risk in recessive model (OR = 0.07, 95% CI = 0.02–0.22, pFDR < 0.01; OR = 0.56, 95% CI = 0.35–0.89, pFDR = 0.042), while ELOVL2 rs17606561, rs3756963, and rs9468304 were associated with increased ASD risk in overdominant model (OR = 1.63, 95% CI = 1.12–2.36, pFDR = 0.036; OR = 1.64, 95% CI = 1.14–2.37, pFDR = 0.039; OR = 1.75, 95% CI = 1.22–2.50, pFDR = 0.017). The A/A genotype of rs10498676 was correlated with a decline in the Autism Diagnostic Interview-Revised communication (verbal and nonverbal) domain. These findings provide evidence of an association between FADS2 and ELOVL2 polymorphisms and ASD susceptibility in Chinese children." @default.
• W2890166307 created "2018-09-27" @default.
• W2890166307 creator A5004105834 @default.
• W2890166307 creator A5017666190 @default.
• W2890166307 creator A5025438590 @default.
• W2890166307 creator A5028119176 @default.
• W2890166307 creator A5045042179 @default.
• W2890166307 creator A5048782499 @default.
• W2890166307 creator A5066525650 @default.
• W2890166307 creator A5071503368 @default.
• W2890166307 creator A5072860912 @default.
• W2890166307 date "2018-09-04" @default.
• W2890166307 modified "2023-10-02" @default.
• W2890166307 title "FADS1-FADS2 and ELOVL2 gene polymorphisms in susceptibility to autism spectrum disorders in Chinese children" @default.
• W2890166307 cites W102069247 @default.
• W2890166307 cites W1548073962 @default.
• W2890166307 cites W1771515148 @default.
• W2890166307 cites W1964011803 @default.
• W2890166307 cites W1973174725 @default.
• W2890166307 cites W1992677117 @default.
• W2890166307 cites W2000849147 @default.
• W2890166307 cites W2030781391 @default.
• W2890166307 cites W2049078997 @default.
• W2890166307 cites W2051230880 @default.
• W2890166307 cites W2052431418 @default.
• W2890166307 cites W2075364461 @default.
• W2890166307 cites W2077233786 @default.
• W2890166307 cites W2078866410 @default.
• W2890166307 cites W2082187068 @default.
• W2890166307 cites W2095595424 @default.
• W2890166307 cites W2097695579 @default.
• W2890166307 cites W2104132149 @default.
• W2890166307 cites W2123735324 @default.
• W2890166307 cites W2125466734 @default.
• W2890166307 cites W2129516277 @default.
• W2890166307 cites W2149251767 @default.
• W2890166307 cites W2153360765 @default.
• W2890166307 cites W2156333779 @default.
• W2890166307 cites W2160923256 @default.
• W2890166307 cites W2161056057 @default.
• W2890166307 cites W2167914935 @default.
• W2890166307 cites W2172099178 @default.
• W2890166307 cites W2259658859 @default.
• W2890166307 cites W2275882422 @default.
• W2890166307 cites W2317689929 @default.
• W2890166307 cites W2331945835 @default.
• W2890166307 cites W2397834057 @default.
• W2890166307 cites W2417530705 @default.
• W2890166307 cites W2441240109 @default.
• W2890166307 cites W2505400815 @default.
• W2890166307 cites W4247665917 @default.
• W2890166307 doi "https://doi.org/10.1186/s12888-018-1868-7" @default.
• W2890166307 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6122697" @default.
• W2890166307 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30180836" @default.
• W2890166307 hasPublicationYear "2018" @default.
• W2890166307 type Work @default.
• W2890166307 sameAs 2890166307 @default.
• W2890166307 citedByCount "18" @default.
• W2890166307 countsByYear W28901663072019 @default.
• W2890166307 countsByYear W28901663072020 @default.
• W2890166307 countsByYear W28901663072021 @default.
• W2890166307 countsByYear W28901663072022 @default.
• W2890166307 countsByYear W28901663072023 @default.
• W2890166307 crossrefType "journal-article" @default.
• W2890166307 hasAuthorship W2890166307A5004105834 @default.
• W2890166307 hasAuthorship W2890166307A5017666190 @default.
• W2890166307 hasAuthorship W2890166307A5025438590 @default.
• W2890166307 hasAuthorship W2890166307A5028119176 @default.
• W2890166307 hasAuthorship W2890166307A5045042179 @default.
• W2890166307 hasAuthorship W2890166307A5048782499 @default.
• W2890166307 hasAuthorship W2890166307A5066525650 @default.
• W2890166307 hasAuthorship W2890166307A5071503368 @default.
• W2890166307 hasAuthorship W2890166307A5072860912 @default.
• W2890166307 hasBestOaLocation W28901663071 @default.
• W2890166307 hasConcept C104317684 @default.
• W2890166307 hasConcept C118552586 @default.
• W2890166307 hasConcept C126322002 @default.
• W2890166307 hasConcept C135763542 @default.
• W2890166307 hasConcept C153209595 @default.
• W2890166307 hasConcept C19038510 @default.
• W2890166307 hasConcept C205778803 @default.
• W2890166307 hasConcept C2777171753 @default.
• W2890166307 hasConcept C2778915593 @default.
• W2890166307 hasConcept C543025807 @default.
• W2890166307 hasConcept C54355233 @default.
• W2890166307 hasConcept C55493867 @default.
• W2890166307 hasConcept C60644358 @default.
• W2890166307 hasConcept C71924100 @default.
• W2890166307 hasConcept C86803240 @default.
• W2890166307 hasConceptScore W2890166307C104317684 @default.
• W2890166307 hasConceptScore W2890166307C118552586 @default.
• W2890166307 hasConceptScore W2890166307C126322002 @default.
• W2890166307 hasConceptScore W2890166307C135763542 @default.
• W2890166307 hasConceptScore W2890166307C153209595 @default.
• W2890166307 hasConceptScore W2890166307C19038510 @default.
• W2890166307 hasConceptScore W2890166307C205778803 @default.
• W2890166307 hasConceptScore W2890166307C2777171753 @default.
• W2890166307 hasConceptScore W2890166307C2778915593 @default.
• W2890166307 hasConceptScore W2890166307C543025807 @default.
• W2890166307 hasConceptScore W2890166307C54355233 @default.

• next