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• W2890168286 abstract "Nodding syndrome is an epidemic neurologic disorder of unknown cause that affects children in the subsistence-farming communities of East Africa. We report the neuropathologic findings in five fatal cases (13-18 years of age at death) of nodding syndrome from the Acholi people in northern Uganda. Neuropathologic examination revealed tau-immunoreactive neuronal neurofibrillary tangles, pre-tangles, neuropil threads, and dot-like lesions involving the cerebral cortex, subcortical nuclei and brainstem. There was preferential involvement of the frontal and temporal lobes in a patchy distribution, mostly involving the crests of gyri and the superficial cortical lamina. The mesencephalopontine tegmental nuclei, substantia nigra, and locus coeruleus revealed globose neurofibrillary tangles and threads. We conclude that nodding syndrome is a tauopathy and may represent a newly recognized neurodegenerative disease." @default.
• W2890168286 created "2018-09-27" @default.
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• W2890168286 date "2018-09-15" @default.
• W2890168286 modified "2023-10-17" @default.
• W2890168286 title "Nodding syndrome in Uganda is a tauopathy" @default.
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• W2890168286 doi "https://doi.org/10.1007/s00401-018-1909-9" @default.
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