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- W2890169564 abstract "Tau protein—a member of the microtubule-associated protein family—is a key protein involved in many neurodegenerative diseases. Tau pathology in neurodegenerative diseases is characterized by pathological tau aggregation in neurofibrillary tangles (NFTs). Diseases with this typical pathological feature are called tauopathies. Parkinson's disease (PD) was not initially considered to be a typical tauopathy. However, recent studies have demonstrated increasing evidence of tau pathology in PD. A genome-wide association (GWA) study indicated a potential association between tauopathy and sporadic PD. The aggregation and deposition of tau were also observed in approximately 50% of PD brains, and it seems to be transported from neuron to neuron. The aggregation of NFTs, the abnormal hyperphosphorylation of tau protein, and the interaction between tau and alpha-synuclein may all contribute to the cell death and poor axonal transport observed in PD and Parkinsonism." @default.
- W2890169564 created "2018-09-27" @default.
- W2890169564 creator A5003753200 @default.
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- W2890169564 date "2018-10-02" @default.
- W2890169564 modified "2023-10-05" @default.
- W2890169564 title "Tau Pathology in Parkinson's Disease" @default.
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- W2890169564 doi "https://doi.org/10.3389/fneur.2018.00809" @default.
- W2890169564 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6176019" @default.
- W2890169564 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30333786" @default.
- W2890169564 hasPublicationYear "2018" @default.