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- W2890169834 abstract "Bulk-level measurements of dynamics have suggested that phase-separated, protein-nucleic acid rich droplets can be viewed as simple liquids. In this report, we show that histone proteins spontaneously phase separate into liquid-like droplets in the presence of DNA. Using super-resolution fluorescence microscopy, we find that molecular transport in these droplets is non-Fickian (subdiffusive) at nanoscopic length scales. This observation cannot be explained by charge-charge interactions. Instead, our results strongly suggest that cation-π interactions drive the non-Fickian behavior. Given the ubiquity of cationic and aromatic moieties in protein-nucleic acid rich liquid-like phases observed in cells, we anticipate that non-Fickian diffusion is a general transport mechanism in such phases." @default.
- W2890169834 created "2018-09-27" @default.
- W2890169834 creator A5007397396 @default.
- W2890169834 creator A5076875965 @default.
- W2890169834 date "2018-09-18" @default.
- W2890169834 modified "2023-10-05" @default.
- W2890169834 title "Non-Fickian Molecular Transport in Protein–DNA Droplets" @default.
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- W2890169834 doi "https://doi.org/10.1021/acsmacrolett.8b00565" @default.
- W2890169834 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35651258" @default.
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