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- W2890173184 abstract "Selection occurs at all stages of folliculogenesis and involves both the oocyte and somatic cells. Follicles are either nongrowing (primordial follicles), growing (primary, secondary, antral), or atretic. The selection of primordial follicles in the ovarian reserve, established early in life, provides all growing follicles and ovulated oocytes. The transition from preantral (primary and secondary) through the antral stages is follicle-stimulating hormone (FSH) dependent, and culminates in dominance being achieved in waves by one or more follicles. As dominant follicles grow, they secrete more inhibin and estradiol, reducing circulating FSH thereby lowering the tropic support required by subordinate follicles which regress. Dominant follicles survive this low FSH environment through paracrine action of growth factors, such as vascular endothelial growth factor, insulin-like growth factor 1, and estrogen. The oocyte plays a major role in the selection process by promoting early follicle growth, and controlling its own development through the production and paracrine actions of growth differentiation factor 9, bone morphogenetic protein 15 and the heterodimer, cumulin. The oocyte is also involved in determining the ovulation rate and maintaining meiotic arrest prior to the luteinizing-surge." @default.
- W2890173184 created "2018-09-27" @default.
- W2890173184 creator A5007839058 @default.
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- W2890173184 creator A5076561635 @default.
- W2890173184 creator A5085173358 @default.
- W2890173184 creator A5090327179 @default.
- W2890173184 date "2019-01-01" @default.
- W2890173184 modified "2023-10-14" @default.
- W2890173184 title "Follicle Selection in Mammalian Ovaries" @default.
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