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• W2890174411 startingPage "1928" @default.
• W2890174411 abstract "Four new cyclodepsipeptides, dinghupeptins A-D (1-4), possessing a rare N5-(2-hydroxylethyl)glutamine moiety, were isolated from cultures of the soil-derived Streptomyces sp. SC0581. Their structures were elucidated by spectroscopic and advanced Marfey's amino acid analysis, and their 3D structures were established by theoretical conformational analysis. Compounds 1 and 2, containing a 3-amino-6-hydroxypiperidone unit, displayed selective inhibition of chymotrypsin with IC50 values of 2.1 and 1.1 μM, respectively. Enzyme kinetic analysis and molecular docking experiments revealed they are competitive inhibitors binding to the active site of chymotrypsin." @default.
• W2890174411 created "2018-09-27" @default.
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• W2890174411 date "2018-09-17" @default.
• W2890174411 modified "2023-10-13" @default.
• W2890174411 title "Dinghupeptins A–D, Chymotrypsin Inhibitory Cyclodepsipeptides Produced by a Soil-Derived Streptomyces" @default.
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• W2890174411 doi "https://doi.org/10.1021/acs.jnatprod.7b01009" @default.
• W2890174411 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30222343" @default.
• W2890174411 hasPublicationYear "2018" @default.
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