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• W2890176467 abstract "Generation of reactive oxygen species (ROS), triggered by ultraviolet radiation (UVR), is associated with carcinogenesis of the skin. UV irradiation induced superoxide anion (O2•-) is the key ROS involved in the cellular damage. The cytoprotective efficacy of an unknown anti-oxidant compound can be evaluated by analyzing the production of O2•- from treated cells.In this study, a glass carbon electrode functionalized with nanotube@DNA-Mn3(PO4)2 composite was applied to quantitative determination of generation of highly unstable O2•- from the melanoma A375 cell line following UVR(UV, UVA and UVB). In addition, the cytoprotective efficacy of anti-oxidant α-tocopherol was evaluated by quantifying the production of O2•-.The results showed that, UVR triggers generation of O2•- in melanoma A375 cells, and α-tocopherol is effective in diminishing the production of O2•- following UV irradiation. By comparing the conventional cell-survival assays results, we found that our simple and quick electrochemical sensing method can quantify O2•- generation through the biological activity of an anti-oxidant compound (α-tocopherol).Our label-free electrochemical quantification method for ROS (O2•- major) in cells facing UVR stress demonstrates its potential application for high-throughput screening of anti-oxidation compounds." @default.
• W2890176467 created "2018-09-27" @default.
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• W2890176467 date "2018-09-12" @default.
• W2890176467 modified "2023-10-12" @default.
• W2890176467 title "Label-free electrochemical sensor to investigate the effect of tocopherol on generation of superoxide ions following UV irradiation" @default.
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• W2890176467 doi "https://doi.org/10.1186/s13036-018-0099-2" @default.
• W2890176467 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6134779" @default.
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• W2890176467 hasPublicationYear "2018" @default.
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