Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890176747> ?p ?o ?g. }
- W2890176747 endingPage "325" @default.
- W2890176747 startingPage "319" @default.
- W2890176747 abstract "Psoriasis is a usual immune-mediated inflammatory skin disease with undefined pathogenesis. Aromatic-turmerone (ATM) is a mainly constituent of essential oil from Curcuma longa L. It has been shown to exhibit strong anti-oxidant, anti-tumor activities and anti-inflammatory effects. In this study, we investigated the effects of ATM on imiquimod (IMQ)-induced psoriasis-like BALB/c mice and its molecular mechanisms for anti-inflammatory effect. ATM showed inhibition of the transfer of CD8+ T cells in epidermis, and reduced expression of NF-κB and COX-2 as well as phosphorylation of p38 MAPK. It also decreased the level of TNF-α and IL-6, and down-regulates IL-17 IL-22 and IL-23 mRNA synthesis. Notably, we demonstrated that topically applied ATM alleviated skin inflammation in IMQ-induced mice. These results indicate that ATM, a natural active compound exhibits anti-inflammatory activity and is a promising candidate molecule to treat inflammatory skin diseases, such as psoriasis." @default.
- W2890176747 created "2018-09-27" @default.
- W2890176747 creator A5016038041 @default.
- W2890176747 creator A5024986501 @default.
- W2890176747 creator A5026269412 @default.
- W2890176747 creator A5030980350 @default.
- W2890176747 creator A5040128703 @default.
- W2890176747 creator A5048635954 @default.
- W2890176747 creator A5057602226 @default.
- W2890176747 creator A5061954077 @default.
- W2890176747 creator A5088915238 @default.
- W2890176747 creator A5089393928 @default.
- W2890176747 creator A5091413959 @default.
- W2890176747 date "2018-11-01" @default.
- W2890176747 modified "2023-10-10" @default.
- W2890176747 title "Aromatic-turmerone ameliorates imiquimod-induced psoriasis-like inflammation of BALB/c mice" @default.
- W2890176747 cites W1939997832 @default.
- W2890176747 cites W1962929997 @default.
- W2890176747 cites W1972179974 @default.
- W2890176747 cites W1991119127 @default.
- W2890176747 cites W1993862299 @default.
- W2890176747 cites W2002756960 @default.
- W2890176747 cites W2003425690 @default.
- W2890176747 cites W2012606189 @default.
- W2890176747 cites W2018905034 @default.
- W2890176747 cites W2031979684 @default.
- W2890176747 cites W2045065875 @default.
- W2890176747 cites W2050524172 @default.
- W2890176747 cites W2068757064 @default.
- W2890176747 cites W2072414393 @default.
- W2890176747 cites W2075339470 @default.
- W2890176747 cites W2094863064 @default.
- W2890176747 cites W2107432039 @default.
- W2890176747 cites W2109873198 @default.
- W2890176747 cites W2111610574 @default.
- W2890176747 cites W2127834887 @default.
- W2890176747 cites W2131964222 @default.
- W2890176747 cites W2148609228 @default.
- W2890176747 cites W2162482755 @default.
- W2890176747 cites W2294112063 @default.
- W2890176747 cites W2322390243 @default.
- W2890176747 cites W2549511634 @default.
- W2890176747 cites W2566924768 @default.
- W2890176747 cites W2568160425 @default.
- W2890176747 cites W2584961612 @default.
- W2890176747 cites W2801736079 @default.
- W2890176747 cites W4211202219 @default.
- W2890176747 cites W4250753642 @default.
- W2890176747 doi "https://doi.org/10.1016/j.intimp.2018.09.015" @default.
- W2890176747 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30243067" @default.
- W2890176747 hasPublicationYear "2018" @default.
- W2890176747 type Work @default.
- W2890176747 sameAs 2890176747 @default.
- W2890176747 citedByCount "36" @default.
- W2890176747 countsByYear W28901767472019 @default.
- W2890176747 countsByYear W28901767472020 @default.
- W2890176747 countsByYear W28901767472021 @default.
- W2890176747 countsByYear W28901767472022 @default.
- W2890176747 countsByYear W28901767472023 @default.
- W2890176747 crossrefType "journal-article" @default.
- W2890176747 hasAuthorship W2890176747A5016038041 @default.
- W2890176747 hasAuthorship W2890176747A5024986501 @default.
- W2890176747 hasAuthorship W2890176747A5026269412 @default.
- W2890176747 hasAuthorship W2890176747A5030980350 @default.
- W2890176747 hasAuthorship W2890176747A5040128703 @default.
- W2890176747 hasAuthorship W2890176747A5048635954 @default.
- W2890176747 hasAuthorship W2890176747A5057602226 @default.
- W2890176747 hasAuthorship W2890176747A5061954077 @default.
- W2890176747 hasAuthorship W2890176747A5088915238 @default.
- W2890176747 hasAuthorship W2890176747A5089393928 @default.
- W2890176747 hasAuthorship W2890176747A5091413959 @default.
- W2890176747 hasConcept C11960822 @default.
- W2890176747 hasConcept C136449434 @default.
- W2890176747 hasConcept C167672396 @default.
- W2890176747 hasConcept C17991360 @default.
- W2890176747 hasConcept C185592680 @default.
- W2890176747 hasConcept C203014093 @default.
- W2890176747 hasConcept C2776709828 @default.
- W2890176747 hasConcept C2776914184 @default.
- W2890176747 hasConcept C2777230291 @default.
- W2890176747 hasConcept C2779112978 @default.
- W2890176747 hasConcept C2779836521 @default.
- W2890176747 hasConcept C2780564577 @default.
- W2890176747 hasConcept C2780942790 @default.
- W2890176747 hasConcept C502942594 @default.
- W2890176747 hasConcept C51551487 @default.
- W2890176747 hasConcept C55493867 @default.
- W2890176747 hasConcept C556039675 @default.
- W2890176747 hasConcept C57074206 @default.
- W2890176747 hasConcept C71924100 @default.
- W2890176747 hasConcept C8891405 @default.
- W2890176747 hasConcept C98274493 @default.
- W2890176747 hasConceptScore W2890176747C11960822 @default.
- W2890176747 hasConceptScore W2890176747C136449434 @default.
- W2890176747 hasConceptScore W2890176747C167672396 @default.
- W2890176747 hasConceptScore W2890176747C17991360 @default.
- W2890176747 hasConceptScore W2890176747C185592680 @default.
- W2890176747 hasConceptScore W2890176747C203014093 @default.