Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890178361> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2890178361 endingPage "1625" @default.
- W2890178361 startingPage "1617" @default.
- W2890178361 abstract "Abstract BACKGROUND Endothelin-1 (ET-1) is a vasoconstrictor produced by vascular endothelial cells and may play a role in risk for development of coronary artery disease (CAD) and heart failure (HF). In a cohort of 1084 patients referred for coronary angiography, we investigated cross-sectional associations between ET-1 concentrations and prevalent CAD, as well as value of ET-1 for prognostication of future cardiovascular events. METHODS Associations between ET-1 and presence/severity of CAD were assessed. Patients were followed for a median of 4 years for outcomes including incident HF, myocardial infarction (MI), cardiovascular mortality, and all-cause mortality. RESULTS The median concentration of ET-1 was 2.57 ng/L. Patients with ET-1 concentrations above the median were more likely to have higher risk clinical features. Among those without prevalent MI at presentation, ET-1 concentrations were not associated with presence or severity of CAD. In adjusted Cox proportional hazards analyses, log-transformed ET-1 concentrations predicted incident HF [hazard ratio (HR) = 1.51 per increase in log-SD; 95% CI, 1.06–2.15; P = 0.02] and all-cause mortality (HR = 1.61 per increase in log-SD; 95% CI, 1.03–2.53; P = 0.04). Concentrations of ET-1 above the median were associated with shorter time to incident HF, MI, cardiovascular mortality, all-cause mortality, and the composite of incident HF/MI/cardiovascular mortality (all log-rank P < 0.001). CONCLUSIONS Despite epidemiologic links to CAD, we found no cross-sectional association between biologically active ET-1 and prevalent coronary atherosclerosis in an at-risk population referred for coronary angiography. Increased ET-1 concentrations independently predict incident HF and death and are associated with more near-term cardiovascular events." @default.
- W2890178361 created "2018-09-27" @default.
- W2890178361 creator A5008596377 @default.
- W2890178361 creator A5021299742 @default.
- W2890178361 creator A5022435518 @default.
- W2890178361 creator A5027561648 @default.
- W2890178361 creator A5028204841 @default.
- W2890178361 creator A5043064522 @default.
- W2890178361 creator A5050177584 @default.
- W2890178361 creator A5056519896 @default.
- W2890178361 creator A5068283804 @default.
- W2890178361 creator A5078252006 @default.
- W2890178361 creator A5090714442 @default.
- W2890178361 date "2018-11-01" @default.
- W2890178361 modified "2023-09-27" @default.
- W2890178361 title "Endothelin-1 Measurement in Patients Undergoing Diagnostic Coronary Angiography—Results from the Catheter Sampled Blood Archive in Cardiovascular Diseases (CASABLANCA) Study" @default.
- W2890178361 cites W1984087017 @default.
- W2890178361 cites W1998832564 @default.
- W2890178361 cites W2001439220 @default.
- W2890178361 cites W2005040933 @default.
- W2890178361 cites W2007200889 @default.
- W2890178361 cites W2036927158 @default.
- W2890178361 cites W2039669614 @default.
- W2890178361 cites W2098636543 @default.
- W2890178361 cites W2110192403 @default.
- W2890178361 cites W2187633246 @default.
- W2890178361 cites W2237748717 @default.
- W2890178361 cites W2281802592 @default.
- W2890178361 cites W2413889436 @default.
- W2890178361 cites W2555007319 @default.
- W2890178361 cites W2607845025 @default.
- W2890178361 cites W2739458618 @default.
- W2890178361 cites W2792755377 @default.
- W2890178361 cites W4292856638 @default.
- W2890178361 doi "https://doi.org/10.1373/clinchem.2017.286385" @default.
- W2890178361 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30213784" @default.
- W2890178361 hasPublicationYear "2018" @default.
- W2890178361 type Work @default.
- W2890178361 sameAs 2890178361 @default.
- W2890178361 citedByCount "7" @default.
- W2890178361 countsByYear W28901783612019 @default.
- W2890178361 countsByYear W28901783612020 @default.
- W2890178361 countsByYear W28901783612021 @default.
- W2890178361 countsByYear W28901783612022 @default.
- W2890178361 crossrefType "journal-article" @default.
- W2890178361 hasAuthorship W2890178361A5008596377 @default.
- W2890178361 hasAuthorship W2890178361A5021299742 @default.
- W2890178361 hasAuthorship W2890178361A5022435518 @default.
- W2890178361 hasAuthorship W2890178361A5027561648 @default.
- W2890178361 hasAuthorship W2890178361A5028204841 @default.
- W2890178361 hasAuthorship W2890178361A5043064522 @default.
- W2890178361 hasAuthorship W2890178361A5050177584 @default.
- W2890178361 hasAuthorship W2890178361A5056519896 @default.
- W2890178361 hasAuthorship W2890178361A5068283804 @default.
- W2890178361 hasAuthorship W2890178361A5078252006 @default.
- W2890178361 hasAuthorship W2890178361A5090714442 @default.
- W2890178361 hasBestOaLocation W28901783611 @default.
- W2890178361 hasConcept C126322002 @default.
- W2890178361 hasConcept C164705383 @default.
- W2890178361 hasConcept C207103383 @default.
- W2890178361 hasConcept C2778213512 @default.
- W2890178361 hasConcept C44249647 @default.
- W2890178361 hasConcept C500558357 @default.
- W2890178361 hasConcept C50382708 @default.
- W2890178361 hasConcept C71924100 @default.
- W2890178361 hasConcept C72563966 @default.
- W2890178361 hasConceptScore W2890178361C126322002 @default.
- W2890178361 hasConceptScore W2890178361C164705383 @default.
- W2890178361 hasConceptScore W2890178361C207103383 @default.
- W2890178361 hasConceptScore W2890178361C2778213512 @default.
- W2890178361 hasConceptScore W2890178361C44249647 @default.
- W2890178361 hasConceptScore W2890178361C500558357 @default.
- W2890178361 hasConceptScore W2890178361C50382708 @default.
- W2890178361 hasConceptScore W2890178361C71924100 @default.
- W2890178361 hasConceptScore W2890178361C72563966 @default.
- W2890178361 hasIssue "11" @default.
- W2890178361 hasLocation W28901783611 @default.
- W2890178361 hasLocation W28901783612 @default.
- W2890178361 hasOpenAccess W2890178361 @default.
- W2890178361 hasPrimaryLocation W28901783611 @default.
- W2890178361 hasRelatedWork W1997605627 @default.
- W2890178361 hasRelatedWork W2007773758 @default.
- W2890178361 hasRelatedWork W2008851126 @default.
- W2890178361 hasRelatedWork W2049397185 @default.
- W2890178361 hasRelatedWork W2085050035 @default.
- W2890178361 hasRelatedWork W2089715561 @default.
- W2890178361 hasRelatedWork W2155913505 @default.
- W2890178361 hasRelatedWork W2399063111 @default.
- W2890178361 hasRelatedWork W2417414779 @default.
- W2890178361 hasRelatedWork W2790353319 @default.
- W2890178361 hasVolume "64" @default.
- W2890178361 isParatext "false" @default.
- W2890178361 isRetracted "false" @default.
- W2890178361 magId "2890178361" @default.
- W2890178361 workType "article" @default.