FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890178643> ?p ?o ?g. }

• W2890178643 endingPage "294" @default.
• W2890178643 startingPage "280" @default.
• W2890178643 abstract "The involvement of macroautophagy/autophagy proteins in B-cell receptor (BCR) trafficking, although suspected, is not well understood. We show that ATG5 (autophagy related 5) contributes to BCR polarization after stimulation and internalization into LAMP1 (lysosomal-associated membrane protein 1)+ and major histocompatibility complex class II (MHC-II)+ compartments. BCR polarization is crucial in the context of immobilized antigen processing. Moreover, antigen presentation to cognate T cells is decreased in the absence of ATG5 when the model antigen OVAL/ovalbumin is provided in an immobilized form in contrast to the normal presentation of soluble OVAL. We further show that ATG5 is required for centrosome polarization and actin nucleation in the immune synapse area. This event is accompanied by an increased interaction between ATG16L1 (autophagy related 16-like 1 [S. cerevisiae]) and the microtubule-organizing center-associated protein PCM1 (pericentriolar material 1). In the human B cell line BJAB, PCM1 is required for BCR polarization after stimulation. We thus propose that the ATG12 (autophagy related 12)–ATG5-ATG16L1 complex under BCR stimulation allows its interaction with PCM1 and consequently facilitates centrosome relocalization to the immune synapse, optimizing the presentation of particulate antigens.Abbreviations: ACTB: actin beta; ACTR2/3: ARP2/3 actin-related protein 2/3; APC: antigen-presenting cells; ATG: autophagy-related; BCR: B cell receptor; BECN1/Beclin 1: beclin 1, autophagy related; CDC42: cell division cycle 42; Cr2: complement receptor 2; CSFE: carboxyfluorescein succinimidyl ester; DAPI: 4ʹ,6-diamidino-2-phenylindole dihydrochloride; EEA1: early endosome antigen 1; ELISA: enzyme-linked immunosorbent assay; FITC: fluorescein isothyocyanate; GC: germinal center; GJA1/CX3: gap junction protein, alpha 1; Ig: immunoglobulin; LAMP1: lysosomal-associated membrane protein 1; LAP: LC3-associated phagocytosis; LM: littermate; MAP1LC3/LC3: microtubule-associated protein 1 light chain 3; MAPK/ERK: mitogen activated protein kinase; MHC-II: major histocompatibility complex class II; MIIC: MHC class II compartment; OVAL: ovalbumin; PBS: phosphate-buffered saline; PCM1: pericentriolar material 1; PtdIns3K: phosphatidylinositol 3-kinase; PTPRC/CD45RB/B220; Protein tyrosine phosphatase, receptor type, C; SYK: spleen tyrosine kinase; TBS: Tris-buffered saline; TCR: T cell receptor; ULK1: unc-51 like kinase 1" @default.
• W2890178643 created "2018-09-27" @default.
• W2890178643 creator A5000506088 @default.
• W2890178643 creator A5015280980 @default.
• W2890178643 creator A5025269258 @default.
• W2890178643 creator A5035921599 @default.
• W2890178643 creator A5040970005 @default.
• W2890178643 creator A5046920175 @default.
• W2890178643 creator A5059004015 @default.
• W2890178643 creator A5060900047 @default.
• W2890178643 creator A5084613098 @default.
• W2890178643 creator A5089651460 @default.
• W2890178643 date "2018-09-22" @default.
• W2890178643 modified "2023-10-15" @default.
• W2890178643 title "ATG5 is required for B cell polarization and presentation of particulate antigens" @default.
• W2890178643 cites W1640130749 @default.
• W2890178643 cites W1666706706 @default.
• W2890178643 cites W1864635191 @default.
• W2890178643 cites W1937243106 @default.
• W2890178643 cites W1974135904 @default.
• W2890178643 cites W1983090571 @default.
• W2890178643 cites W1985478291 @default.
• W2890178643 cites W1987467930 @default.
• W2890178643 cites W1988376910 @default.
• W2890178643 cites W2013295182 @default.
• W2890178643 cites W2022976260 @default.
• W2890178643 cites W2034306306 @default.
• W2890178643 cites W2045389135 @default.
• W2890178643 cites W2048023375 @default.
• W2890178643 cites W2070216538 @default.
• W2890178643 cites W2072953299 @default.
• W2890178643 cites W2079525834 @default.
• W2890178643 cites W2085102335 @default.
• W2890178643 cites W2100427942 @default.
• W2890178643 cites W2113206573 @default.
• W2890178643 cites W2116100639 @default.
• W2890178643 cites W2116379983 @default.
• W2890178643 cites W2120553887 @default.
• W2890178643 cites W2124712366 @default.
• W2890178643 cites W2130314992 @default.
• W2890178643 cites W2136088887 @default.
• W2890178643 cites W2138261040 @default.
• W2890178643 cites W2142598127 @default.
• W2890178643 cites W2145607980 @default.
• W2890178643 cites W2146783761 @default.
• W2890178643 cites W2148281700 @default.
• W2890178643 cites W2211562053 @default.
• W2890178643 cites W2219755458 @default.
• W2890178643 cites W2416963577 @default.
• W2890178643 cites W2554915504 @default.
• W2890178643 cites W2594104586 @default.
• W2890178643 cites W2735296240 @default.
• W2890178643 cites W2951598355 @default.
• W2890178643 cites W4313310587 @default.
• W2890178643 doi "https://doi.org/10.1080/15548627.2018.1516327" @default.
• W2890178643 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6333460" @default.
• W2890178643 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30196744" @default.
• W2890178643 hasPublicationYear "2018" @default.
• W2890178643 type Work @default.
• W2890178643 sameAs 2890178643 @default.
• W2890178643 citedByCount "35" @default.
• W2890178643 countsByYear W28901786432018 @default.
• W2890178643 countsByYear W28901786432019 @default.
• W2890178643 countsByYear W28901786432020 @default.
• W2890178643 countsByYear W28901786432021 @default.
• W2890178643 countsByYear W28901786432022 @default.
• W2890178643 countsByYear W28901786432023 @default.
• W2890178643 crossrefType "journal-article" @default.
• W2890178643 hasAuthorship W2890178643A5000506088 @default.
• W2890178643 hasAuthorship W2890178643A5015280980 @default.
• W2890178643 hasAuthorship W2890178643A5025269258 @default.
• W2890178643 hasAuthorship W2890178643A5035921599 @default.
• W2890178643 hasAuthorship W2890178643A5040970005 @default.
• W2890178643 hasAuthorship W2890178643A5046920175 @default.
• W2890178643 hasAuthorship W2890178643A5059004015 @default.
• W2890178643 hasAuthorship W2890178643A5060900047 @default.
• W2890178643 hasAuthorship W2890178643A5084613098 @default.
• W2890178643 hasAuthorship W2890178643A5089651460 @default.
• W2890178643 hasBestOaLocation W28901786431 @default.
• W2890178643 hasConcept C157695867 @default.
• W2890178643 hasConcept C159654299 @default.
• W2890178643 hasConcept C190283241 @default.
• W2890178643 hasConcept C203014093 @default.
• W2890178643 hasConcept C203522944 @default.
• W2890178643 hasConcept C2778453870 @default.
• W2890178643 hasConcept C2781000418 @default.
• W2890178643 hasConcept C55493867 @default.
• W2890178643 hasConcept C86803240 @default.
• W2890178643 hasConcept C95444343 @default.
• W2890178643 hasConceptScore W2890178643C157695867 @default.
• W2890178643 hasConceptScore W2890178643C159654299 @default.
• W2890178643 hasConceptScore W2890178643C190283241 @default.
• W2890178643 hasConceptScore W2890178643C203014093 @default.
• W2890178643 hasConceptScore W2890178643C203522944 @default.
• W2890178643 hasConceptScore W2890178643C2778453870 @default.
• W2890178643 hasConceptScore W2890178643C2781000418 @default.
• W2890178643 hasConceptScore W2890178643C55493867 @default.
• W2890178643 hasConceptScore W2890178643C86803240 @default.

• next