FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890181831> ?p ?o ?g. }

• W2890181831 abstract "Abstract Background Esophageal Squamous Cell Carcinoma(ESCC) comprises 90% of esophageal cancer worldwide which typically presents at advanced stages and has extremely poor outcomes. Established risk factors for ESCC include tobacco, alcohol and betel nut use. We hypothesized that a screening program for high risk subjects could be established in a low- to middle-income country, using a low-cost, non-endoscopic, retrievable capsule sponge device called EsophaCap(EC). Methods The Institutional Review Board-approved study was conducted in western India from March 2017 through February 2018. Patients with high risk characteristics(smoking, tobacco, betel nut, alcohol, hot beverage consumption) were included. Patients with severe dysphagia, current upper aerodigestive tract cancer, metastatic cancer, esophageal varices, cirrhosis, and portal hypertension were excluded. Following EC specimen retrieval, endoscopic biopsies were collected at 20cm, 30cm and from any visible mucosal abnormalities. Cytology and biopsy specimens underwent H&E staining. An interim analysis was performed to make necessary changes given the lack of baseline data in this field. Results Of the 100 enrolled subjects(85% males, median age 50 years), 93% successfully swallowed the EC and 90% completed endoscopy. The median patient experience score on a 6-point visual analog scale was 5(‘minimal discomfort’). Six(7%) subjects had ESCC on their biopsy. In 2 ESCC patients with mild dysphagia, sponge cytology accurately detected atypical squamous cells(ASC) and dysplasia(100% Sensitivity & Specificity). The other 4 ESCC patients had moderate dysphagia with a near-complete obstruction. In 2 asymptomatic patients with no mucosal abnormalities on endoscopy or biopsies, sponge cytology detected ASC. Longitudinal follow-up of these patients is ongoing. On biopsies from twenty-one(23%) patients, leukoplakia was identified. Conclusion ESCC screening using the EC is feasible with good patient tolerance. Analysis of the cytology samples with H&E staining is potentially accurate for patients with non-obstructive lesions but has a high false negative rate in patients with advanced lesions, when the EC can’t traverse the obstruction. An unusually high rate of leukoplakia was detected in this population and will be evaluated as a potentially pre-malignant lesion with increased risk for development of ESCC. Future studies will include high-throughput sequencing to identify molecular changes that may correspond with leukoplakia or dysplastic cells retrieved with the EC. Disclosure All authors have declared no conflicts of interest." @default.
• W2890181831 created "2018-09-27" @default.
• W2890181831 creator A5012932840 @default.
• W2890181831 creator A5021497581 @default.
• W2890181831 creator A5021925495 @default.
• W2890181831 creator A5021970250 @default.
• W2890181831 creator A5026006983 @default.
• W2890181831 creator A5029484310 @default.
• W2890181831 creator A5055942274 @default.
• W2890181831 creator A5061001986 @default.
• W2890181831 creator A5061661547 @default.
• W2890181831 creator A5074998296 @default.
• W2890181831 creator A5083078887 @default.
• W2890181831 date "2018-09-01" @default.
• W2890181831 modified "2023-09-25" @default.
• W2890181831 title "RA07.03: NON-ENDOSCOPIC SCREENING FOR ESOPHAGEAL SQUAMOUS CELL CARCINOMA: INTERIM ANALYSIS" @default.
• W2890181831 doi "https://doi.org/10.1093/dote/doy089.ra07.03" @default.
• W2890181831 hasPublicationYear "2018" @default.
• W2890181831 type Work @default.
• W2890181831 sameAs 2890181831 @default.
• W2890181831 citedByCount "0" @default.
• W2890181831 crossrefType "journal-article" @default.
• W2890181831 hasAuthorship W2890181831A5012932840 @default.
• W2890181831 hasAuthorship W2890181831A5021497581 @default.
• W2890181831 hasAuthorship W2890181831A5021925495 @default.
• W2890181831 hasAuthorship W2890181831A5021970250 @default.
• W2890181831 hasAuthorship W2890181831A5026006983 @default.
• W2890181831 hasAuthorship W2890181831A5029484310 @default.
• W2890181831 hasAuthorship W2890181831A5055942274 @default.
• W2890181831 hasAuthorship W2890181831A5061001986 @default.
• W2890181831 hasAuthorship W2890181831A5061661547 @default.
• W2890181831 hasAuthorship W2890181831A5074998296 @default.
• W2890181831 hasAuthorship W2890181831A5083078887 @default.
• W2890181831 hasConcept C121608353 @default.
• W2890181831 hasConcept C126322002 @default.
• W2890181831 hasConcept C141071460 @default.
• W2890181831 hasConcept C2775934546 @default.
• W2890181831 hasConcept C2777819096 @default.
• W2890181831 hasConcept C2779742542 @default.
• W2890181831 hasConcept C2780596822 @default.
• W2890181831 hasConcept C71924100 @default.
• W2890181831 hasConcept C90924648 @default.
• W2890181831 hasConceptScore W2890181831C121608353 @default.
• W2890181831 hasConceptScore W2890181831C126322002 @default.
• W2890181831 hasConceptScore W2890181831C141071460 @default.
• W2890181831 hasConceptScore W2890181831C2775934546 @default.
• W2890181831 hasConceptScore W2890181831C2777819096 @default.
• W2890181831 hasConceptScore W2890181831C2779742542 @default.
• W2890181831 hasConceptScore W2890181831C2780596822 @default.
• W2890181831 hasConceptScore W2890181831C71924100 @default.
• W2890181831 hasConceptScore W2890181831C90924648 @default.
• W2890181831 hasLocation W28901818311 @default.
• W2890181831 hasOpenAccess W2890181831 @default.
• W2890181831 hasPrimaryLocation W28901818311 @default.
• W2890181831 hasRelatedWork W1982083971 @default.
• W2890181831 hasRelatedWork W1986687640 @default.
• W2890181831 hasRelatedWork W1988641280 @default.
• W2890181831 hasRelatedWork W2051493696 @default.
• W2890181831 hasRelatedWork W2058040569 @default.
• W2890181831 hasRelatedWork W2757572252 @default.
• W2890181831 hasRelatedWork W2759789497 @default.
• W2890181831 hasRelatedWork W3137905056 @default.
• W2890181831 hasRelatedWork W4238017469 @default.
• W2890181831 hasRelatedWork W4247484490 @default.
• W2890181831 isParatext "false" @default.
• W2890181831 isRetracted "false" @default.
• W2890181831 magId "2890181831" @default.
• W2890181831 workType "article" @default.