Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890184494> ?p ?o ?g. }
- W2890184494 endingPage "137" @default.
- W2890184494 startingPage "129" @default.
- W2890184494 abstract "Paeonol is a natural phenolic compound in Moutan Cortex with multiple biological functions, such as anti-inflammatory and anti-oxidant activity. Recent evidence has proven that persistent inflammation, oxidative stress, along with nuclear factor E2-related factor 2 (Nrf2) signaling dysfunction in periodontium are the possible causes of alveolar bone resorption, and ultimately lead to periodontitis. The present study was designed to explore the protective effects of paeonol on ligation-induced periodontitis in rats, and investigate the possible mechanism. We found that treatment with paeonol (40, 80 mg/kg, intraperitoneal injection) for 7 days remarkably decreased the expression of receptor activator of nuclear factor kappa-B ligand increased the expression of osteoprotegrin and inhibited the formation of osteoclasts. This function of paeonol might be correlated with its ability to reduce inflammatory factors (IL-1β, IL-6 and TNF-α) and alleviate oxidative stress (SOD, MDA, GSH and ROS) in gingival tissues. Besides, paeonol increased Nrf2 activity. Silence of Nrf2 using specific siRNA diminished the inhibitory effect of paeonol on NF-κB p65 activation and downstream expression, suggesting that Nrf2 was essential for protective effect of paeonol. These results showed that paeonol protected against periodontitis-aggravated osteoclastogenesis and alveolar bone lesion via regulating Nrf2/NF-κB/NFATc1 signaling pathway." @default.
- W2890184494 created "2018-09-27" @default.
- W2890184494 creator A5021541475 @default.
- W2890184494 creator A5036309714 @default.
- W2890184494 creator A5041744833 @default.
- W2890184494 creator A5042772858 @default.
- W2890184494 creator A5064803348 @default.
- W2890184494 creator A5085974836 @default.
- W2890184494 date "2019-01-01" @default.
- W2890184494 modified "2023-10-14" @default.
- W2890184494 title "Paeonol attenuates ligation-induced periodontitis in rats by inhibiting osteoclastogenesis via regulating Nrf2/NF-κB/NFATc1 signaling pathway" @default.
- W2890184494 cites W1533021978 @default.
- W2890184494 cites W1967502057 @default.
- W2890184494 cites W1969107610 @default.
- W2890184494 cites W1974120192 @default.
- W2890184494 cites W1985260819 @default.
- W2890184494 cites W1992724001 @default.
- W2890184494 cites W1997072139 @default.
- W2890184494 cites W2001219292 @default.
- W2890184494 cites W2002315265 @default.
- W2890184494 cites W2010534173 @default.
- W2890184494 cites W2018299513 @default.
- W2890184494 cites W2019008302 @default.
- W2890184494 cites W2019945693 @default.
- W2890184494 cites W2048961393 @default.
- W2890184494 cites W2049293744 @default.
- W2890184494 cites W2049594701 @default.
- W2890184494 cites W2064163702 @default.
- W2890184494 cites W2075633105 @default.
- W2890184494 cites W209966876 @default.
- W2890184494 cites W2121778907 @default.
- W2890184494 cites W2123346255 @default.
- W2890184494 cites W2128714725 @default.
- W2890184494 cites W2131350538 @default.
- W2890184494 cites W2133584350 @default.
- W2890184494 cites W2140261918 @default.
- W2890184494 cites W2149150871 @default.
- W2890184494 cites W2173444583 @default.
- W2890184494 cites W2530829140 @default.
- W2890184494 cites W2549589438 @default.
- W2890184494 cites W2616814628 @default.
- W2890184494 cites W2687183192 @default.
- W2890184494 cites W2730451865 @default.
- W2890184494 cites W2750479320 @default.
- W2890184494 cites W2756811650 @default.
- W2890184494 doi "https://doi.org/10.1016/j.biochi.2018.09.004" @default.
- W2890184494 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30213522" @default.
- W2890184494 hasPublicationYear "2019" @default.
- W2890184494 type Work @default.
- W2890184494 sameAs 2890184494 @default.
- W2890184494 citedByCount "34" @default.
- W2890184494 countsByYear W28901844942019 @default.
- W2890184494 countsByYear W28901844942020 @default.
- W2890184494 countsByYear W28901844942021 @default.
- W2890184494 countsByYear W28901844942022 @default.
- W2890184494 countsByYear W28901844942023 @default.
- W2890184494 crossrefType "journal-article" @default.
- W2890184494 hasAuthorship W2890184494A5021541475 @default.
- W2890184494 hasAuthorship W2890184494A5036309714 @default.
- W2890184494 hasAuthorship W2890184494A5041744833 @default.
- W2890184494 hasAuthorship W2890184494A5042772858 @default.
- W2890184494 hasAuthorship W2890184494A5064803348 @default.
- W2890184494 hasAuthorship W2890184494A5085974836 @default.
- W2890184494 hasConcept C126322002 @default.
- W2890184494 hasConcept C142724271 @default.
- W2890184494 hasConcept C185592680 @default.
- W2890184494 hasConcept C204787440 @default.
- W2890184494 hasConcept C2776151105 @default.
- W2890184494 hasConcept C2776914184 @default.
- W2890184494 hasConcept C2777730290 @default.
- W2890184494 hasConcept C2778833331 @default.
- W2890184494 hasConcept C2779526882 @default.
- W2890184494 hasConcept C2779730028 @default.
- W2890184494 hasConcept C2780385504 @default.
- W2890184494 hasConcept C55493867 @default.
- W2890184494 hasConcept C62478195 @default.
- W2890184494 hasConcept C673006 @default.
- W2890184494 hasConcept C71924100 @default.
- W2890184494 hasConcept C98274493 @default.
- W2890184494 hasConceptScore W2890184494C126322002 @default.
- W2890184494 hasConceptScore W2890184494C142724271 @default.
- W2890184494 hasConceptScore W2890184494C185592680 @default.
- W2890184494 hasConceptScore W2890184494C204787440 @default.
- W2890184494 hasConceptScore W2890184494C2776151105 @default.
- W2890184494 hasConceptScore W2890184494C2776914184 @default.
- W2890184494 hasConceptScore W2890184494C2777730290 @default.
- W2890184494 hasConceptScore W2890184494C2778833331 @default.
- W2890184494 hasConceptScore W2890184494C2779526882 @default.
- W2890184494 hasConceptScore W2890184494C2779730028 @default.
- W2890184494 hasConceptScore W2890184494C2780385504 @default.
- W2890184494 hasConceptScore W2890184494C55493867 @default.
- W2890184494 hasConceptScore W2890184494C62478195 @default.
- W2890184494 hasConceptScore W2890184494C673006 @default.
- W2890184494 hasConceptScore W2890184494C71924100 @default.
- W2890184494 hasConceptScore W2890184494C98274493 @default.
- W2890184494 hasLocation W28901844941 @default.
- W2890184494 hasLocation W28901844942 @default.
- W2890184494 hasOpenAccess W2890184494 @default.