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• W2890187186 abstract "KRAS is a driver mutation for malignant transformation, found in 30% of all cancers and in 90% of pancreatic cancer. The identification of small molecules inhibiting selectively KRAS mutants has been challenging, yet mutant KRAS has recently been shown to be targeted by tumor infiltrating T-cells that confer, upon adoptive transfer, tumor regression (Tran, NEJM, 375, 2255, 2016). A human IgG1 monoclonal antibody interfering with mutant KRAS function has been described (Shin, Nat. Comm. 8, 15090, 2017) to inhibit growth of KRAS mutant xenografts. B-cells have been described to infiltrate pancreatic cancer, they may be associated with TLS (tertiary lymphoid structures) associated with good prognosis - or to promote tumor growth. However, their function, nor their antigen-specificity has been defined. We discuss here the presence of tumor-infiltrating B-cells from patients with pancreatic cancer that produce KRAS-mutant specific IgG. This underlines that intra-tumoral T- and B-cells are able to exclusively target mutant KRAS and that KRAS – specific IgG that could be used as a blueprint for the construction of tumor-reactive chimeric antigen receptors (CARs), even if B-cells may promote tumor growth." @default.
• W2890187186 created "2018-09-27" @default.
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• W2890187186 date "2018-09-19" @default.
• W2890187186 modified "2023-10-01" @default.
• W2890187186 title "KRAS RENAISSANCE(S) in Tumor Infiltrating B Cells in Pancreatic Cancer" @default.
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• W2890187186 doi "https://doi.org/10.3389/fonc.2018.00384" @default.
• W2890187186 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6156365" @default.
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