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- W2890189115 abstract "The mechanisms by which exosomes (nano-vesicular messengers of cells) are taken up by recipient cells are poorly understood. We hypothesized that histones associated with these nanoparticles are the ligands which facilitate their interaction with cell surface syndecan-4 (SDC4) to mediate their uptake. We show that the incubation with fetuin-A (exosome-associated proteins) and histones mediates the uptake of exosomes that are normally not endocytosed. Similarly, hydroxyapatite-nanoparticles incubated with fetuin-A and histones (FNH) are internalized by tumor cells, while nanoparticles incubated with fetuin-A alone (FN) are not. The uptake of exosomes and FNH, both of which move to the perinuclear region of the cell, is attenuated in SDC4-knockdown cells. Data show that FNH can compete with exosomes for uptake and that both use SDC4 as uptake receptors." @default.
- W2890189115 created "2018-09-27" @default.
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- W2890189115 date "2018-09-20" @default.
- W2890189115 modified "2023-10-16" @default.
- W2890189115 title "Extracellular histones are the ligands for the uptake of exosomes and hydroxyapatite‐nanoparticles by tumor cells<i>via</i>syndecan‐4" @default.
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- W2890189115 doi "https://doi.org/10.1002/1873-3468.13236" @default.
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- W2890189115 hasPublicationYear "2018" @default.
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