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• W2890190585 abstract "<b><i>Background:</i></b> Arteriovenous fistulae impair the distal circulation, but their effects at the microcirculatory level are not well understood. This study presents the carotid-jugular fistula (CJF) as a model to evaluate fistula-related microcirculatory and systemic changes. <b><i>Materials and Methods:</i></b> Female Wistar rats were anesthetized and divided into a fistula group (FG, <i>n</i> = 10) and a sham group (SG, <i>n</i> = 6). End-to-end anastomosis was performed between the right carotid artery and the jugular vein in the FG. The hemodynamic status was followed for 6 weeks. On the sixth postoperative week, liver and kidney microcirculation was measured using laser Doppler; then microcirculatory changes were assessed after occlusion of the carotid artery. At the end of the experiment, histological samples were taken and the weights of the organs were measured. <b><i>Results:</i></b> The heart rate and systolic blood pressure decreased significantly due to the CJF. Laser Doppler showed a reduction in liver blood flow units (BFU) in the FG in comparison with the SG (<i>p</i> = 0.01), and they increased (<i>p</i> &#x3c; 0.01) after occlusion of the fistula. Kidney BFU showed slight changes only. The comparative morphological study revealed significant increases in heart weight (<i>p</i> &#x3c; 0.001) and left ventricular hypertrophy (<i>p</i> = 0.008) in the FG. <b><i>Conclusion:</i></b> Beside hemodynamic and morphologic changes, a CJF causes a deterioration in the microcirculation of the liver rather than of the kidney, but occlusion of the CJF immediately reverses these changes." @default.
• W2890190585 created "2018-09-27" @default.
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• W2890190585 date "2018-01-01" @default.
• W2890190585 modified "2023-09-27" @default.
• W2890190585 title "Carotid-Jugular Fistula Model to Study Systemic Effects and Fistula-Related Microcirculatory Changes" @default.
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• W2890190585 doi "https://doi.org/10.1159/000491930" @default.
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