FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890193821> ?p ?o ?g. }

• W2890193821 endingPage "240" @default.
• W2890193821 startingPage "229" @default.
• W2890193821 abstract "This study examined the effects of metastasis-directed stereotactic body radiation therapy (mdSBRT) on CD8+ T-cell subpopulations and correlated post-mdSBRT immunophenotypic responses with clinical outcomes in patients with oligometastatic prostate cancer (OPCa).Peripheral blood mononuclear cells were prospectively isolated from 37 patients with OPCa (≤3 metastases) who were treated with mdSBRT. Immunophenotyping identified circulating CD8+ T-cell subpopulations, including tumor-reactive (TTR), effector memory, central memory (TCM), effector, and naïve T cells from samples collected before and after mdSBRT. Univariate Cox proportional hazards regression was used to assess whether changes in these T-cell subpopulations were potential risk factors for death and/or progression. The Kaplan-Meier method was used for survival. Cumulative incidence for progression and new distant metastasis weas estimated, considering death as a competing risk.Median follow-up was 39 months (interquartile range, 34-43). Overall survival at 3 years was 78.2%. Cumulative incidence for local progression and new distant metastasis at 3 years was 16.5% and 67.6%, respectively. Between baseline and day 14 after mdSBRT, an increase in the TCM cell subpopulation was associated with the risk of death (hazard ratio, 1.22 [95% confidence interval, 1.02-1.47]; P = .033), and an increase in the TTR cell subpopulation was protective against the risk of local progression (hazard ratio, 0.80 [95% confidence interval, 0.65-0.98]; P = .032).An increase in the TTR cell subpopulation was protective against the risk of disease progression, and an increase in the TCM cell subpopulation was associated with the risk of death in patients with OPCa treated with mdSBRT. Disease control may be further improved by better understanding the CD8+ T-cell subpopulations and by enhancing their antitumor effect." @default.
• W2890193821 created "2018-09-27" @default.
• W2890193821 creator A5005150037 @default.
• W2890193821 creator A5012788874 @default.
• W2890193821 creator A5021587684 @default.
• W2890193821 creator A5021687717 @default.
• W2890193821 creator A5023100809 @default.
• W2890193821 creator A5023733267 @default.
• W2890193821 creator A5027176998 @default.
• W2890193821 creator A5038413156 @default.
• W2890193821 creator A5040586351 @default.
• W2890193821 creator A5048628138 @default.
• W2890193821 creator A5049144598 @default.
• W2890193821 creator A5054056429 @default.
• W2890193821 creator A5071440718 @default.
• W2890193821 creator A5075568883 @default.
• W2890193821 creator A5079400879 @default.
• W2890193821 creator A5083170859 @default.
• W2890193821 date "2019-01-01" @default.
• W2890193821 modified "2023-09-26" @default.
• W2890193821 title "Prospective Immunophenotyping of CD8+ T Cells and Associated Clinical Outcomes of Patients With Oligometastatic Prostate Cancer Treated With Metastasis-Directed SBRT" @default.
• W2890193821 cites W1963798982 @default.
• W2890193821 cites W1978942158 @default.
• W2890193821 cites W1979811833 @default.
• W2890193821 cites W1981291019 @default.
• W2890193821 cites W1982658780 @default.
• W2890193821 cites W1992007584 @default.
• W2890193821 cites W2004870869 @default.
• W2890193821 cites W2015671099 @default.
• W2890193821 cites W2016983859 @default.
• W2890193821 cites W2042474090 @default.
• W2890193821 cites W2043904711 @default.
• W2890193821 cites W2050146329 @default.
• W2890193821 cites W2056491603 @default.
• W2890193821 cites W2069380387 @default.
• W2890193821 cites W2073373264 @default.
• W2890193821 cites W2081061928 @default.
• W2890193821 cites W2100626956 @default.
• W2890193821 cites W2100928937 @default.
• W2890193821 cites W2103959341 @default.
• W2890193821 cites W2108463536 @default.
• W2890193821 cites W2112064048 @default.
• W2890193821 cites W2114156781 @default.
• W2890193821 cites W2118742901 @default.
• W2890193821 cites W2122940327 @default.
• W2890193821 cites W2136706275 @default.
• W2890193821 cites W2149752186 @default.
• W2890193821 cites W2159180573 @default.
• W2890193821 cites W2168219324 @default.
• W2890193821 cites W2268596702 @default.
• W2890193821 cites W2293494611 @default.
• W2890193821 cites W2318502789 @default.
• W2890193821 cites W2346198650 @default.
• W2890193821 cites W2346316361 @default.
• W2890193821 cites W2493219106 @default.
• W2890193821 cites W2504612473 @default.
• W2890193821 cites W2511755939 @default.
• W2890193821 cites W2518564428 @default.
• W2890193821 cites W2555296848 @default.
• W2890193821 cites W2677307903 @default.
• W2890193821 cites W2737968130 @default.
• W2890193821 cites W2739862798 @default.
• W2890193821 cites W2753027941 @default.
• W2890193821 cites W2775321189 @default.
• W2890193821 cites W287605918 @default.
• W2890193821 doi "https://doi.org/10.1016/j.ijrobp.2018.09.001" @default.
• W2890193821 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6301146" @default.
• W2890193821 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30205124" @default.
• W2890193821 hasPublicationYear "2019" @default.
• W2890193821 type Work @default.
• W2890193821 sameAs 2890193821 @default.
• W2890193821 citedByCount "19" @default.
• W2890193821 countsByYear W28901938212019 @default.
• W2890193821 countsByYear W28901938212020 @default.
• W2890193821 countsByYear W28901938212021 @default.
• W2890193821 countsByYear W28901938212022 @default.
• W2890193821 countsByYear W28901938212023 @default.
• W2890193821 crossrefType "journal-article" @default.
• W2890193821 hasAuthorship W2890193821A5005150037 @default.
• W2890193821 hasAuthorship W2890193821A5012788874 @default.
• W2890193821 hasAuthorship W2890193821A5021587684 @default.
• W2890193821 hasAuthorship W2890193821A5021687717 @default.
• W2890193821 hasAuthorship W2890193821A5023100809 @default.
• W2890193821 hasAuthorship W2890193821A5023733267 @default.
• W2890193821 hasAuthorship W2890193821A5027176998 @default.
• W2890193821 hasAuthorship W2890193821A5038413156 @default.
• W2890193821 hasAuthorship W2890193821A5040586351 @default.
• W2890193821 hasAuthorship W2890193821A5048628138 @default.
• W2890193821 hasAuthorship W2890193821A5049144598 @default.
• W2890193821 hasAuthorship W2890193821A5054056429 @default.
• W2890193821 hasAuthorship W2890193821A5071440718 @default.
• W2890193821 hasAuthorship W2890193821A5075568883 @default.
• W2890193821 hasAuthorship W2890193821A5079400879 @default.
• W2890193821 hasAuthorship W2890193821A5083170859 @default.
• W2890193821 hasBestOaLocation W28901938212 @default.
• W2890193821 hasConcept C119060515 @default.
• W2890193821 hasConcept C121608353 @default.
• W2890193821 hasConcept C126322002 @default.

• next