FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890195831> ?p ?o ?g. }

• W2890195831 startingPage "418012" @default.
• W2890195831 abstract "Background: Long-term HIV infection, even with successful combination antiretroviral therapy (cART), is associated with an enhanced and accentuated onset of premature-aging or age-related diseases in people living with HIV (PLHIV). No data are available from low- and middle-income countries (LMICs) like India on inflamm-aging. In this study, we attempt to understand the relationship between several biomarkers of inflamm-aging in a well-defined Indian cohort of PLHIV.Methods: Blood samples were obtained from therapy-naive PLHIV (Pre-ART, n=43), patients on cART (ART, n=53) and age and gender-matched healthy controls (HC, n=41) after screening 714 individuals. We measured telomere length, 92 markers of inflammation, immune activation markers, and HIV-1 reservoir coupled with clinical phenotypes and neurocognitive function assessments using the International HIV Dementia Scale (IHDS). Findings: Despite a median duration of eight years of cART, sCD14 (p<0.001) and sCD163 (p=0.0377) was not normalized to the level of HC. Significant differences were observed in 11 inflammatory markers between HC and ART (p<0.05). Linear regression analysis showed a significant negative association of HIV-1 positive status on telomere length (-2.687, p<0.0001). There was a significant association between HIV status and higher odds of having IHDS≤10 (OR:39.74, p<0.0001). A significant negative association of CCL20 (-0.5236, p=0.0219) and CCL11 (-1.1608, p=0.0338) with HIV-1 reservoir was also observed.Interpretation: Our study suggests that PLHIV on successful cART in a standardized public-health setting, may be at higher risk of inflamm-aging and age-related inflammatory diseases which may need special intervention and identifies several biomarkers for further mechanistic investigation." @default.
• W2890195831 created "2018-09-27" @default.
• W2890195831 creator A5001770656 @default.
• W2890195831 creator A5002455613 @default.
• W2890195831 creator A5023267495 @default.
• W2890195831 creator A5032742387 @default.
• W2890195831 creator A5046296775 @default.
• W2890195831 creator A5047685213 @default.
• W2890195831 creator A5051368546 @default.
• W2890195831 creator A5053298608 @default.
• W2890195831 creator A5053300883 @default.
• W2890195831 creator A5064585599 @default.
• W2890195831 creator A5067915814 @default.
• W2890195831 creator A5077776400 @default.
• W2890195831 creator A5078018616 @default.
• W2890195831 creator A5081193550 @default.
• W2890195831 date "2018-09-14" @default.
• W2890195831 modified "2023-09-30" @default.
• W2890195831 title "Systemic inflammation following long-term successful antiretroviral therapy in people living with HIV (PLHIV)" @default.
• W2890195831 cites W1822037535 @default.
• W2890195831 cites W1824374475 @default.
• W2890195831 cites W1849900443 @default.
• W2890195831 cites W1965019797 @default.
• W2890195831 cites W1969385194 @default.
• W2890195831 cites W1970089787 @default.
• W2890195831 cites W1971673060 @default.
• W2890195831 cites W1981885339 @default.
• W2890195831 cites W1990891654 @default.
• W2890195831 cites W1996321192 @default.
• W2890195831 cites W1998927357 @default.
• W2890195831 cites W2001571331 @default.
• W2890195831 cites W2004216239 @default.
• W2890195831 cites W2010084870 @default.
• W2890195831 cites W2014865423 @default.
• W2890195831 cites W2043876312 @default.
• W2890195831 cites W2054172399 @default.
• W2890195831 cites W2055303465 @default.
• W2890195831 cites W2058743791 @default.
• W2890195831 cites W2066816136 @default.
• W2890195831 cites W2066885413 @default.
• W2890195831 cites W2070036973 @default.
• W2890195831 cites W2088271176 @default.
• W2890195831 cites W2090213025 @default.
• W2890195831 cites W2098152094 @default.
• W2890195831 cites W2102223205 @default.
• W2890195831 cites W2121449768 @default.
• W2890195831 cites W2137321682 @default.
• W2890195831 cites W2141280520 @default.
• W2890195831 cites W2144252296 @default.
• W2890195831 cites W2145245207 @default.
• W2890195831 cites W2147647246 @default.
• W2890195831 cites W2159047279 @default.
• W2890195831 cites W2411826498 @default.
• W2890195831 cites W2415904000 @default.
• W2890195831 cites W2432649889 @default.
• W2890195831 cites W2509879210 @default.
• W2890195831 cites W2606764675 @default.
• W2890195831 cites W2650614302 @default.
• W2890195831 cites W2735761770 @default.
• W2890195831 cites W2755457130 @default.
• W2890195831 cites W2770287703 @default.
• W2890195831 cites W2790870349 @default.
• W2890195831 hasPublicationYear "2018" @default.
• W2890195831 type Work @default.
• W2890195831 sameAs 2890195831 @default.
• W2890195831 citedByCount "0" @default.
• W2890195831 crossrefType "posted-content" @default.
• W2890195831 hasAuthorship W2890195831A5001770656 @default.
• W2890195831 hasAuthorship W2890195831A5002455613 @default.
• W2890195831 hasAuthorship W2890195831A5023267495 @default.
• W2890195831 hasAuthorship W2890195831A5032742387 @default.
• W2890195831 hasAuthorship W2890195831A5046296775 @default.
• W2890195831 hasAuthorship W2890195831A5047685213 @default.
• W2890195831 hasAuthorship W2890195831A5051368546 @default.
• W2890195831 hasAuthorship W2890195831A5053298608 @default.
• W2890195831 hasAuthorship W2890195831A5053300883 @default.
• W2890195831 hasAuthorship W2890195831A5064585599 @default.
• W2890195831 hasAuthorship W2890195831A5067915814 @default.
• W2890195831 hasAuthorship W2890195831A5077776400 @default.
• W2890195831 hasAuthorship W2890195831A5078018616 @default.
• W2890195831 hasAuthorship W2890195831A5081193550 @default.
• W2890195831 hasBestOaLocation W28901958311 @default.
• W2890195831 hasConcept C118552586 @default.
• W2890195831 hasConcept C126322002 @default.
• W2890195831 hasConcept C127413603 @default.
• W2890195831 hasConcept C142462285 @default.
• W2890195831 hasConcept C169900460 @default.
• W2890195831 hasConcept C172467417 @default.
• W2890195831 hasConcept C203014093 @default.
• W2890195831 hasConcept C2776252253 @default.
• W2890195831 hasConcept C2776914184 @default.
• W2890195831 hasConcept C2777275308 @default.
• W2890195831 hasConcept C2779134260 @default.
• W2890195831 hasConcept C2779483572 @default.
• W2890195831 hasConcept C2993143319 @default.
• W2890195831 hasConcept C3013748606 @default.
• W2890195831 hasConcept C71924100 @default.
• W2890195831 hasConcept C72563966 @default.
• W2890195831 hasConcept C78519656 @default.

• next