FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890199186> ?p ?o ?g. }

• W2890199186 endingPage "1433" @default.
• W2890199186 startingPage "1427" @default.
• W2890199186 abstract "Rationale: Previous studies have suggested that interstitial lung disease (ILD) progresses most rapidly early in the course of systemic sclerosis–associated (SSc)-ILD, and that SSc-ILD is often more stable or even “burned out” after the first 4 years following diagnosis.Objectives: Our objectives were to determine whether an apparent plateau in pulmonary function decline is due to survival bias and to identify distinct prognostic phenotypes of ILD progression.Methods: Consecutive patients with SSc-ILD from a single center were included. Pulmonary function measurements were typically performed every 6 months. Study participants were categorized into long-term survivors (>8 yr survival from diagnosis), and those with medium-term and short-term mortality (4–8 and <4 yr survival, respectively). We excluded those censored with less than 8 years of follow-up. Subject-specific slopes for change in forced vital capacity (FVC) and diffusing capacity of the lung for carbon monoxide (DlCO) were calculated using generalized linear models with mixed effects. The rate of decline in FVC was compared across prognostic groups.Results: The cohort included 171 study participants with SSc-ILD. A plateau in the progression of FVC was apparent in the full cohort analysis but disappeared with stratification into prognostic subgroups to account for survival bias. Those with short-term mortality had a higher annual rate of decline in FVC (−4.10 [95% confidence interval (CI), −7.92 to −0.28] vs. −2.14 [95% CI, −3.31 to −0.97] and −0.94 [−1.46 to −0.42]; P = 0.003) and DlCO (−5.28 [95% CI, −9.58 to −0.99] vs. −3.13 [95% CI, −4.35 to −1.92] and −1.32 [95% CI, −2.01 to −0.63]; P < 0.001) than those with medium-term mortality and long-term survival with adjustment for age, sex, and pack-years. Change in FVC in the previous year did not predict FVC change in the subsequent year.Conclusions: Adults with SSc-ILD have distinct patterns of physiological progression that remain relatively consistent during long-term follow-up; however, recent change in FVC cannot be used to predict future change in FVC within shorter follow-up intervals. The findings of this study provide important information on the course of disease in SSc-ILD and identify specific phenotypes of progression that may improve clinical decision-making and design of future therapeutic trials." @default.
• W2890199186 created "2018-09-27" @default.
• W2890199186 creator A5025858579 @default.
• W2890199186 creator A5033032729 @default.
• W2890199186 creator A5061095405 @default.
• W2890199186 creator A5061342020 @default.
• W2890199186 creator A5063687930 @default.
• W2890199186 creator A5069388315 @default.
• W2890199186 creator A5072392852 @default.
• W2890199186 creator A5073698659 @default.
• W2890199186 creator A5077408702 @default.
• W2890199186 creator A5089980624 @default.
• W2890199186 date "2018-12-01" @default.
• W2890199186 modified "2023-10-14" @default.
• W2890199186 title "Does Systemic Sclerosis–associated Interstitial Lung Disease Burn Out? Specific Phenotypes of Disease Progression" @default.
• W2890199186 cites W1971696904 @default.
• W2890199186 cites W2000193050 @default.
• W2890199186 cites W2002114847 @default.
• W2890199186 cites W2028921539 @default.
• W2890199186 cites W2042096696 @default.
• W2890199186 cites W2042113729 @default.
• W2890199186 cites W2095975942 @default.
• W2890199186 cites W2100422140 @default.
• W2890199186 cites W2102003406 @default.
• W2890199186 cites W2116531828 @default.
• W2890199186 cites W2125078269 @default.
• W2890199186 cites W2130052733 @default.
• W2890199186 cites W2131014787 @default.
• W2890199186 cites W2140044661 @default.
• W2890199186 cites W2141922649 @default.
• W2890199186 cites W2146965595 @default.
• W2890199186 cites W2149839143 @default.
• W2890199186 cites W2206255006 @default.
• W2890199186 cites W2498506084 @default.
• W2890199186 cites W2508060872 @default.
• W2890199186 cites W2624827840 @default.
• W2890199186 cites W2742100186 @default.
• W2890199186 cites W2750520295 @default.
• W2890199186 cites W2755069867 @default.
• W2890199186 cites W2766145635 @default.
• W2890199186 cites W2768154273 @default.
• W2890199186 cites W2789284875 @default.
• W2890199186 cites W2803995891 @default.
• W2890199186 cites W4245666729 @default.
• W2890199186 doi "https://doi.org/10.1513/annalsats.201806-362oc" @default.
• W2890199186 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30188737" @default.
• W2890199186 hasPublicationYear "2018" @default.
• W2890199186 type Work @default.
• W2890199186 sameAs 2890199186 @default.
• W2890199186 citedByCount "51" @default.
• W2890199186 countsByYear W28901991862019 @default.
• W2890199186 countsByYear W28901991862020 @default.
• W2890199186 countsByYear W28901991862021 @default.
• W2890199186 countsByYear W28901991862022 @default.
• W2890199186 countsByYear W28901991862023 @default.
• W2890199186 crossrefType "journal-article" @default.
• W2890199186 hasAuthorship W2890199186A5025858579 @default.
• W2890199186 hasAuthorship W2890199186A5033032729 @default.
• W2890199186 hasAuthorship W2890199186A5061095405 @default.
• W2890199186 hasAuthorship W2890199186A5061342020 @default.
• W2890199186 hasAuthorship W2890199186A5063687930 @default.
• W2890199186 hasAuthorship W2890199186A5069388315 @default.
• W2890199186 hasAuthorship W2890199186A5072392852 @default.
• W2890199186 hasAuthorship W2890199186A5073698659 @default.
• W2890199186 hasAuthorship W2890199186A5077408702 @default.
• W2890199186 hasAuthorship W2890199186A5089980624 @default.
• W2890199186 hasConcept C126322002 @default.
• W2890199186 hasConcept C16020263 @default.
• W2890199186 hasConcept C165637977 @default.
• W2890199186 hasConcept C2777543607 @default.
• W2890199186 hasConcept C2777714996 @default.
• W2890199186 hasConcept C3018587741 @default.
• W2890199186 hasConcept C44249647 @default.
• W2890199186 hasConcept C55520419 @default.
• W2890199186 hasConcept C71924100 @default.
• W2890199186 hasConcept C72563966 @default.
• W2890199186 hasConcept C75603125 @default.
• W2890199186 hasConceptScore W2890199186C126322002 @default.
• W2890199186 hasConceptScore W2890199186C16020263 @default.
• W2890199186 hasConceptScore W2890199186C165637977 @default.
• W2890199186 hasConceptScore W2890199186C2777543607 @default.
• W2890199186 hasConceptScore W2890199186C2777714996 @default.
• W2890199186 hasConceptScore W2890199186C3018587741 @default.
• W2890199186 hasConceptScore W2890199186C44249647 @default.
• W2890199186 hasConceptScore W2890199186C55520419 @default.
• W2890199186 hasConceptScore W2890199186C71924100 @default.
• W2890199186 hasConceptScore W2890199186C72563966 @default.
• W2890199186 hasConceptScore W2890199186C75603125 @default.
• W2890199186 hasIssue "12" @default.
• W2890199186 hasLocation W28901991861 @default.
• W2890199186 hasLocation W28901991862 @default.
• W2890199186 hasOpenAccess W2890199186 @default.
• W2890199186 hasPrimaryLocation W28901991861 @default.
• W2890199186 hasRelatedWork W1594845867 @default.
• W2890199186 hasRelatedWork W1632012575 @default.
• W2890199186 hasRelatedWork W2084948910 @default.
• W2890199186 hasRelatedWork W2097351176 @default.
• W2890199186 hasRelatedWork W2386294370 @default.

• next