Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890199519> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2890199519 endingPage "369" @default.
- W2890199519 startingPage "364" @default.
- W2890199519 abstract "Lycopene, a tetraterpenoid containing 13 double bonds, has important pharmaceutical and industrial application values. However, unstable supply of raw for extracted from natural host and residue of chemical reagents in chemically synthesized products have limited the quality of lycopene. Engineering microorganism is thus regarded as an alternative and attractive route for lycopene production. To improve the ability of engineered yeast to synthesize lycopene, here we have optimized the lycopene biosynthesis pathway and chassis metabolism. The results have verified that S. cerevisiae CEN.PK2-1C was more suitable for lycopene production because of its strong ability of synthesizing precursors of terpenoids. Compared to use inducible promoter, the use of constitutive promoter controlling pathway expression was more efficient for balancing lycopene synthesis and chassis metabolism. GGPP was identified the rate-controlling metabolite. Through expanding GGPP pool and MVA pathway, lycopene production was thus significantly increased. By citric acid fed-batch fermentation, the yield of lycopene finally reached 115.64 mg/L, 2689-folds of initial engineered yeast. These results indicated that co-optimization of heterologous pathway and chassis metabolism is a good strategy for enforcing microbial overproduction of natural products." @default.
- W2890199519 created "2018-09-27" @default.
- W2890199519 creator A5013092829 @default.
- W2890199519 creator A5063187488 @default.
- W2890199519 creator A5073881802 @default.
- W2890199519 creator A5074934997 @default.
- W2890199519 date "2019-01-01" @default.
- W2890199519 modified "2023-10-10" @default.
- W2890199519 title "Improving lycopene production in Saccharomyces cerevisiae through optimizing pathway and chassis metabolism" @default.
- W2890199519 cites W1806073932 @default.
- W2890199519 cites W1967210731 @default.
- W2890199519 cites W1968212788 @default.
- W2890199519 cites W1977167047 @default.
- W2890199519 cites W1989803156 @default.
- W2890199519 cites W1990226486 @default.
- W2890199519 cites W1997021048 @default.
- W2890199519 cites W2004657630 @default.
- W2890199519 cites W2013048861 @default.
- W2890199519 cites W2023158791 @default.
- W2890199519 cites W2030402605 @default.
- W2890199519 cites W2035045727 @default.
- W2890199519 cites W2041034992 @default.
- W2890199519 cites W2055194955 @default.
- W2890199519 cites W2072369409 @default.
- W2890199519 cites W2094639130 @default.
- W2890199519 cites W2103853678 @default.
- W2890199519 cites W2134294998 @default.
- W2890199519 cites W2142766362 @default.
- W2890199519 cites W2145922781 @default.
- W2890199519 cites W2161257110 @default.
- W2890199519 cites W2404001189 @default.
- W2890199519 cites W2470181883 @default.
- W2890199519 cites W2523461114 @default.
- W2890199519 cites W2734893958 @default.
- W2890199519 cites W2739109447 @default.
- W2890199519 cites W2765854754 @default.
- W2890199519 cites W2768872043 @default.
- W2890199519 doi "https://doi.org/10.1016/j.ces.2018.09.030" @default.
- W2890199519 hasPublicationYear "2019" @default.
- W2890199519 type Work @default.
- W2890199519 sameAs 2890199519 @default.
- W2890199519 citedByCount "29" @default.
- W2890199519 countsByYear W28901995192019 @default.
- W2890199519 countsByYear W28901995192020 @default.
- W2890199519 countsByYear W28901995192021 @default.
- W2890199519 countsByYear W28901995192022 @default.
- W2890199519 countsByYear W28901995192023 @default.
- W2890199519 crossrefType "journal-article" @default.
- W2890199519 hasAuthorship W2890199519A5013092829 @default.
- W2890199519 hasAuthorship W2890199519A5063187488 @default.
- W2890199519 hasAuthorship W2890199519A5073881802 @default.
- W2890199519 hasAuthorship W2890199519A5074934997 @default.
- W2890199519 hasConcept C100544194 @default.
- W2890199519 hasConcept C124420848 @default.
- W2890199519 hasConcept C181199279 @default.
- W2890199519 hasConcept C185592680 @default.
- W2890199519 hasConcept C192989942 @default.
- W2890199519 hasConcept C206103511 @default.
- W2890199519 hasConcept C2777576037 @default.
- W2890199519 hasConcept C2779222958 @default.
- W2890199519 hasConcept C2780022147 @default.
- W2890199519 hasConcept C28781525 @default.
- W2890199519 hasConcept C55493867 @default.
- W2890199519 hasConcept C62231903 @default.
- W2890199519 hasConcept C6350086 @default.
- W2890199519 hasConceptScore W2890199519C100544194 @default.
- W2890199519 hasConceptScore W2890199519C124420848 @default.
- W2890199519 hasConceptScore W2890199519C181199279 @default.
- W2890199519 hasConceptScore W2890199519C185592680 @default.
- W2890199519 hasConceptScore W2890199519C192989942 @default.
- W2890199519 hasConceptScore W2890199519C206103511 @default.
- W2890199519 hasConceptScore W2890199519C2777576037 @default.
- W2890199519 hasConceptScore W2890199519C2779222958 @default.
- W2890199519 hasConceptScore W2890199519C2780022147 @default.
- W2890199519 hasConceptScore W2890199519C28781525 @default.
- W2890199519 hasConceptScore W2890199519C55493867 @default.
- W2890199519 hasConceptScore W2890199519C62231903 @default.
- W2890199519 hasConceptScore W2890199519C6350086 @default.
- W2890199519 hasFunder F4320321001 @default.
- W2890199519 hasFunder F4320322542 @default.
- W2890199519 hasLocation W28901995191 @default.
- W2890199519 hasOpenAccess W2890199519 @default.
- W2890199519 hasPrimaryLocation W28901995191 @default.
- W2890199519 hasRelatedWork W1925643659 @default.
- W2890199519 hasRelatedWork W2004657630 @default.
- W2890199519 hasRelatedWork W2051573163 @default.
- W2890199519 hasRelatedWork W2086592553 @default.
- W2890199519 hasRelatedWork W2123945540 @default.
- W2890199519 hasRelatedWork W2145741655 @default.
- W2890199519 hasRelatedWork W2540731211 @default.
- W2890199519 hasRelatedWork W2586250322 @default.
- W2890199519 hasRelatedWork W2791263336 @default.
- W2890199519 hasRelatedWork W3110571889 @default.
- W2890199519 hasVolume "193" @default.
- W2890199519 isParatext "false" @default.
- W2890199519 isRetracted "false" @default.
- W2890199519 magId "2890199519" @default.
- W2890199519 workType "article" @default.