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- W2890201680 abstract "e15105 Background: In this study we evaluated the role of the chitinase activity (one of the biomarkers) in predicting the liver metastases of colorectal cancer in blood. Methods: The level of chitinase activity were examined in 400 colorectal cancer patients, including 53 synchronous liver metastases in peripheral blood 0.347 colorectal cancer patients peripheral blood was measured before resection of the cancer. The clinical parameters were collected, and the patient were prospectively followed up. Results: The chitinase activity was significantly over-expressed in synchronous liver metastases than colorectal cancer who has no metastases. During the follow up in 347 colorectal cancer patient, higher expression of chitinase activity, higher risk of liver metastases, bothunivariate cox analysis (HR6.0) and multivariate Cox analysis (HR 5.3) show chitinase has high value of predictive the liver metastases after resection of the primary colorectal cancer. Kaplan-Meier analysis shows the chitinase activity has significant correlation to survival in colorectal cancer patients. Moreover, the in vitro study shows the chitinase play important role in cell migration. The metastasis ratio between two groups in non-synchronic colorectal metastasis patients. Conclusions: This study provide experimental evidence that chitinase activity has the potential biomarker for predictive the liver metastases in colorectal cancer. [Table: see text]" @default.
- W2890201680 created "2018-09-27" @default.
- W2890201680 creator A5040177271 @default.
- W2890201680 date "2017-05-20" @default.
- W2890201680 modified "2023-09-25" @default.
- W2890201680 title "Serum chitinase activity to predict survival and metastasis of colorectal cancer." @default.
- W2890201680 doi "https://doi.org/10.1200/jco.2017.35.15_suppl.e15105" @default.
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