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• W2890202337 abstract "Abstract Blood is a complex fluid consisting of cells and plasma. Plasma contains key biomarkers essential for disease diagnosis and therapeutic monitoring. Thus, by separating plasma from the blood, it is possible to analyze these biomarkers. Conventional methods for plasma extraction involve bulky equipment, and miniaturization constitutes a key step to develop portable devices for plasma extraction. Here, we integrated nanomaterial synthesis with microfabrication, and built a microfluidic device. In particular, we designed a double-spiral channel able to perform cross-flow filtration. This channel was constructed by growing aligned carbon nanotubes (CNTs) with average inter-tubular distances of ~80 nm, which resulted in porosity values of ~93%. During blood extraction, these aligned CNTs allow smaller molecules (e.g., proteins) to pass through the channel wall, while larger molecules (e.g., cells) get blocked. Our results show that our device effectively separates plasma from blood, by trapping blood cells. We successfully recovered albumin -the most abundant protein inside plasma- with an efficiency of ~80%. This work constitutes the first report on integrating biocompatible nitrogen-doped CNT (CN x CNT) arrays to extract plasma from human blood, thus widening the bio-applications of CNTs." @default.
• W2890202337 created "2018-09-27" @default.
• W2890202337 creator A5019403402 @default.
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• W2890202337 date "2018-09-11" @default.
• W2890202337 modified "2023-10-18" @default.
• W2890202337 title "A carbon nanotube integrated microfluidic device for blood plasma extraction" @default.
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• W2890202337 doi "https://doi.org/10.1038/s41598-018-31810-x" @default.
• W2890202337 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6133936" @default.
• W2890202337 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30206295" @default.
• W2890202337 hasPublicationYear "2018" @default.
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