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- W2890210756 abstract "Increasing prevalence in obesity has become a significant public concern. C57BL/6J mice are prone to diet-induced obesity (DIO) when fed high-fat diet (HFD), and develop chronic inflammation and metabolic syndrome, making them a good model to analyze mechanisms whereby obesity elicits pathologies. DIO mice demonstrated profound sex differences in response to HFD with respect to inflammation and hypothalamic function. First, we determined that males are prone to DIO, while females are resistant. Ovariectomized females, on the other hand, are susceptible to DIO, implying protection by ovarian hormones. Males, but not females, exhibit changes in hypothalamic neuropeptide expression. Surprisingly, ovariectomized females remain resistant to neuroendocrine changes, showing that ovarian hormones are not necessary for protection. Second, obese mice exhibit sex differences in DIO-induced inflammation. Microglial activation and peripheral macrophage infiltration is seen in the hypothalami of males, while females are protected from the increase in inflammatory cytokines and do not exhibit microglia morphology changes nor monocyte-derived macrophage infiltration, regardless of the presence of ovarian hormones. Strikingly, the anti-inflammatory cytokine IL-10 is increased in the hypothalami of females but not males. Third, this study posits a potential mechanism of obesity-induced impairment of hypothalamic function whereby obese males exhibit reduced levels of synaptic proteins in the hypothalamus and fewer spines in GnRH neurons, located in the areas exhibiting macrophage infiltration. Our studies suggest that inflammation-induced synaptic remodeling is potentially responsible for hypothalamic impairment that may contribute to diminished levels of gonadotropin hormones, testosterone, and sperm numbers, which we observe and corresponds to the observations in obese humans. Taken together, our data implicate neuro-immune mechanisms underlying sex-specific differences in obesity-induced impairment of the hypothalamic function with potential consequences for reproduction and fertility." @default.
- W2890210756 created "2018-09-27" @default.
- W2890210756 creator A5038451412 @default.
- W2890210756 creator A5045643559 @default.
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- W2890210756 creator A5059159627 @default.
- W2890210756 creator A5082544848 @default.
- W2890210756 creator A5083870050 @default.
- W2890210756 date "2018-09-11" @default.
- W2890210756 modified "2023-10-17" @default.
- W2890210756 title "Diet-Induced Obesity Elicits Macrophage Infiltration and Reduction in Spine Density in the Hypothalami of Male but Not Female Mice" @default.
- W2890210756 cites W1040888847 @default.
- W2890210756 cites W11753821 @default.
- W2890210756 cites W1549736805 @default.
- W2890210756 cites W1836567906 @default.
- W2890210756 cites W1964562779 @default.
- W2890210756 cites W1966336914 @default.
- W2890210756 cites W1970253621 @default.
- W2890210756 cites W1978090961 @default.
- W2890210756 cites W1978513870 @default.
- W2890210756 cites W1979733406 @default.
- W2890210756 cites W1979776217 @default.
- W2890210756 cites W1981140048 @default.
- W2890210756 cites W1981298061 @default.
- W2890210756 cites W1982402033 @default.
- W2890210756 cites W1992856395 @default.
- W2890210756 cites W1996185747 @default.
- W2890210756 cites W1998896041 @default.
- W2890210756 cites W2008869160 @default.
- W2890210756 cites W2011693526 @default.
- W2890210756 cites W2013307851 @default.
- W2890210756 cites W2017302135 @default.
- W2890210756 cites W2020748502 @default.
- W2890210756 cites W2021052928 @default.
- W2890210756 cites W2022419155 @default.
- W2890210756 cites W2023655124 @default.
- W2890210756 cites W2024901212 @default.
- W2890210756 cites W2025078194 @default.
- W2890210756 cites W2025131475 @default.
- W2890210756 cites W2026821172 @default.
- W2890210756 cites W2028668178 @default.
- W2890210756 cites W2030183538 @default.
- W2890210756 cites W2032704291 @default.
- W2890210756 cites W2040153748 @default.
- W2890210756 cites W2041384106 @default.
- W2890210756 cites W2041510403 @default.
- W2890210756 cites W2042075182 @default.
- W2890210756 cites W2044219916 @default.
- W2890210756 cites W2047715709 @default.
- W2890210756 cites W2048259921 @default.
- W2890210756 cites W2059082421 @default.
- W2890210756 cites W2060977606 @default.
- W2890210756 cites W2061084753 @default.
- W2890210756 cites W2061514092 @default.
- W2890210756 cites W2062436615 @default.
- W2890210756 cites W2062966472 @default.
- W2890210756 cites W2064880478 @default.
- W2890210756 cites W2076633494 @default.
- W2890210756 cites W2077335475 @default.
- W2890210756 cites W2078575306 @default.
- W2890210756 cites W2078701378 @default.
- W2890210756 cites W2079431196 @default.
- W2890210756 cites W2079643983 @default.
- W2890210756 cites W2082023836 @default.
- W2890210756 cites W2083945553 @default.
- W2890210756 cites W2088942853 @default.
- W2890210756 cites W2090012338 @default.
- W2890210756 cites W2092196676 @default.
- W2890210756 cites W2094978759 @default.
- W2890210756 cites W2097876705 @default.
- W2890210756 cites W2098169357 @default.
- W2890210756 cites W2100853507 @default.
- W2890210756 cites W2101328621 @default.
- W2890210756 cites W2106466636 @default.
- W2890210756 cites W2112004869 @default.
- W2890210756 cites W2122526759 @default.
- W2890210756 cites W2131539537 @default.
- W2890210756 cites W2139833921 @default.
- W2890210756 cites W2145690342 @default.
- W2890210756 cites W2145697808 @default.
- W2890210756 cites W2148257095 @default.
- W2890210756 cites W2153981339 @default.
- W2890210756 cites W2154696002 @default.
- W2890210756 cites W2156236394 @default.
- W2890210756 cites W2157893447 @default.
- W2890210756 cites W2159770387 @default.
- W2890210756 cites W2163961467 @default.
- W2890210756 cites W2164118173 @default.
- W2890210756 cites W2168801563 @default.
- W2890210756 cites W2191806457 @default.
- W2890210756 cites W2213723245 @default.
- W2890210756 cites W2303513279 @default.
- W2890210756 cites W2331855569 @default.
- W2890210756 cites W2341244791 @default.
- W2890210756 cites W2407372765 @default.
- W2890210756 cites W2417996089 @default.
- W2890210756 cites W2506572744 @default.
- W2890210756 cites W2555637551 @default.
- W2890210756 cites W2557209317 @default.