FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890215202> ?p ?o ?g. }

• W2890215202 abstract "The efficacy of stem cell (SC) transplantation in patients with type 1 diabetes mellitus (T1DM) has remained to be fully elucidated. In the present study, a systematic review and meta‑analysis was performed to determine the clinical outcomes. Electronic databases, including PubMed, MEDLINE, WanFang and the Cochrane Library were screened for relevant studies published until January 13, 2018. The references of retrieved papers, systematic reviews and trial registries were manually screened for additional papers. Two authors were involved in screening the titles in order to select eligible studies, extract data and assess the risk of bias. Studies were pooled using a random‑effects model as well as the Begg's funnel plot and subgroup analysis was performed using Stata 14.0 software. A total of 47 studies were retrieved for detailed evaluation, of which 22 met the inclusion criteria. No substantial publication bias was identified. The meta‑analysis revealed that SC therapy increased C‑peptide levels when compared with placebo treatment in randomized‑controlled trials [RCT; standardized mean difference (SMD), 0.93; 95% confidence interval (CI) 0.23‑1.63] and self‑controlled trials (SMD, 0.66; 95% CI, ‑0.22 to 1.54). An analysis demonstrated that SC therapy was more efficient at reducing the glycated hemoglobin level compared with the control group in RCTs (SMD, 0.56; 95% CI; 0.06‑1.06; and SMD, 1.63; 95% CI, 0.92‑2.34, respectively). The graphs demonstrated that SC transplantation resulted in a reduction of insulin requirement. Furthermore, subgroup analyses revealed that patient age, medical history and the SC injection dose may be sources of the heterogeneity observed. The greatest benefit of SC transplantation was seen in patients aged ≥18 years or a medical history of <3 months. In addition, the SC injection dose of ≥107 IU/kg/day was more effective than <107 IU/kg/day when the cellular composition included mesenchymal SCs and hematopoietic SCs. In conclusion, SC therapy represents an efficient option for patients with T1DM. This systematic review was registered at the International prospective register of systematic reviews (no. 42018093930)." @default.
• W2890215202 created "2018-09-27" @default.
• W2890215202 creator A5049874561 @default.
• W2890215202 creator A5075677773 @default.
• W2890215202 date "2018-09-19" @default.
• W2890215202 modified "2023-09-30" @default.
• W2890215202 title "Stem cell transplantation for the treatment of patients with type�1 diabetes mellitus: A meta‑analysis" @default.
• W2890215202 cites W1480729244 @default.
• W2890215202 cites W1599041638 @default.
• W2890215202 cites W170065451 @default.
• W2890215202 cites W1787495218 @default.
• W2890215202 cites W1872007329 @default.
• W2890215202 cites W1942090571 @default.
• W2890215202 cites W1954306482 @default.
• W2890215202 cites W1963526469 @default.
• W2890215202 cites W1982575342 @default.
• W2890215202 cites W1986215651 @default.
• W2890215202 cites W2005501262 @default.
• W2890215202 cites W2006756706 @default.
• W2890215202 cites W2011450045 @default.
• W2890215202 cites W2013448043 @default.
• W2890215202 cites W2038693293 @default.
• W2890215202 cites W204046373 @default.
• W2890215202 cites W2044810689 @default.
• W2890215202 cites W2047786130 @default.
• W2890215202 cites W2056608119 @default.
• W2890215202 cites W2057122597 @default.
• W2890215202 cites W2064431167 @default.
• W2890215202 cites W2067875379 @default.
• W2890215202 cites W2071379321 @default.
• W2890215202 cites W2072874867 @default.
• W2890215202 cites W2083224029 @default.
• W2890215202 cites W2089138079 @default.
• W2890215202 cites W2097222424 @default.
• W2890215202 cites W2101508556 @default.
• W2890215202 cites W2103662974 @default.
• W2890215202 cites W2109565940 @default.
• W2890215202 cites W2110707188 @default.
• W2890215202 cites W2111365775 @default.
• W2890215202 cites W2115646569 @default.
• W2890215202 cites W2115936490 @default.
• W2890215202 cites W2124533082 @default.
• W2890215202 cites W2124812894 @default.
• W2890215202 cites W2126491115 @default.
• W2890215202 cites W2126930838 @default.
• W2890215202 cites W2129570393 @default.
• W2890215202 cites W2133920458 @default.
• W2890215202 cites W2137343316 @default.
• W2890215202 cites W2147402097 @default.
• W2890215202 cites W2155621930 @default.
• W2890215202 cites W2156119394 @default.
• W2890215202 cites W2158020943 @default.
• W2890215202 cites W2158089045 @default.
• W2890215202 cites W2159911604 @default.
• W2890215202 cites W2187102810 @default.
• W2890215202 cites W2193550628 @default.
• W2890215202 cites W2328786770 @default.
• W2890215202 cites W2482212774 @default.
• W2890215202 cites W2606075443 @default.
• W2890215202 cites W2791091077 @default.
• W2890215202 cites W4241473538 @default.
• W2890215202 cites W4243159992 @default.
• W2890215202 cites W4247468517 @default.
• W2890215202 doi "https://doi.org/10.3892/etm.2018.6769" @default.
• W2890215202 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6257425" @default.
• W2890215202 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30542397" @default.
• W2890215202 hasPublicationYear "2018" @default.
• W2890215202 type Work @default.
• W2890215202 sameAs 2890215202 @default.
• W2890215202 citedByCount "7" @default.
• W2890215202 countsByYear W28902152022020 @default.
• W2890215202 countsByYear W28902152022021 @default.
• W2890215202 countsByYear W28902152022022 @default.
• W2890215202 countsByYear W28902152022023 @default.
• W2890215202 crossrefType "journal-article" @default.
• W2890215202 hasAuthorship W2890215202A5049874561 @default.
• W2890215202 hasAuthorship W2890215202A5075677773 @default.
• W2890215202 hasBestOaLocation W28902152021 @default.
• W2890215202 hasConcept C126322002 @default.
• W2890215202 hasConcept C134018914 @default.
• W2890215202 hasConcept C168563851 @default.
• W2890215202 hasConcept C187960798 @default.
• W2890215202 hasConcept C2776478404 @default.
• W2890215202 hasConcept C2777180221 @default.
• W2890215202 hasConcept C2777538456 @default.
• W2890215202 hasConcept C2779473830 @default.
• W2890215202 hasConcept C2780439572 @default.
• W2890215202 hasConcept C28804328 @default.
• W2890215202 hasConcept C2911091166 @default.
• W2890215202 hasConcept C44249647 @default.
• W2890215202 hasConcept C55493867 @default.
• W2890215202 hasConcept C555293320 @default.
• W2890215202 hasConcept C71924100 @default.
• W2890215202 hasConcept C82605166 @default.
• W2890215202 hasConcept C86803240 @default.
• W2890215202 hasConcept C95190672 @default.
• W2890215202 hasConceptScore W2890215202C126322002 @default.
• W2890215202 hasConceptScore W2890215202C134018914 @default.
• W2890215202 hasConceptScore W2890215202C168563851 @default.
• W2890215202 hasConceptScore W2890215202C187960798 @default.

• next