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- W2890219979 abstract "Bacterial vaginosis (BV) and genitalmycoplasmas are infections of the reproductive tract that playimportant roles in maternal and foetal health. Genital mycoplasmasinclude Mycoplasma genitalium, M. hominis, Ureaplasma parvum and U.urealyticum. Infection may increase a woman’s susceptibility toinfection with the human immunodeficiency virus (HIV). Bacterialvaginosis associated bacteria may form biofilms that areresponsible for antimicrobial resistance and about 30% of affectedwomen will relapse within three months of treatment. Genitalmycoplasmas are prone to develop point mutations, which areresponsible for increased antimicrobial resistance. Infections withthese bacteria become prominent during pregnancy as infection maylead to infertility and foetal death. The purpose of the study wasto determine the association between genital mycoplasmas and BV inpregnant women. Pregnant women attending the antenatal and Maternaland Foetal Unit (MAFU) clinics of a tertiary academic hospital inPretoria, South Africa were included in the study. Self-collectedvaginal swab specimens were obtained from consenting women olderthan 18 years of age. With the aid of microscopy, the Nugentscoring system was used to diagnose BV. Genital mycoplasmas werecultured on A2 agar and were diagnosed and speciated with amultiplex polymerase chain reaction (mPCR) assay. In addition,genital mycoplasmas were diagnosed and the antimicrobialsusceptibility profiles determined with the Mycofast Revolutionassay. A quantitative real-time polymerase chain reaction (qPCR)was employed to quantify the BV associated bacteria Atopobiumvaginae and Gardnerella vaginalis. The prevalence of BV in thisstudy was found to be 17.7% in 220 recruited pregnant women.Threshold concentrations between 106 to 107 copies/reaction of A.vaginae and G. vaginalis were found to be the best predictors ofBV. Genital mycoplasmas were poorly recovered from A2 agar media,which had a contamination rate of 54.9%. An mPCR assay revealedthat genital mycoplasmas were prevalent in 2.3% to 71.4% ofspecimens with U. parvum being the most prevalent species. Theresistance of Ureaplasma species to tetracycline and erythromycinwas 73% and 80%, respectively. Minor resistance to thefluoroquinolones, levofloxacin and moxifloxacin was recorded. Thisstudy found that only the genital mycoplasmas, namely M. hominisand U. parvum, were significantly associated with BV, while M.hominis was also significantly isolated from HIV positive women.This study found that there is an association between BV andgenital mycoplasmas. The high prevalence of BV and genitalmycoplasmas suggests that current management and/or interventionstrategies are insufficient. Bacterial vaginosis associatedbacteria can form a polymicrobial biofilm, which confer protectionagainst antimicrobial agents and host immune responses. Thesebiofilms are present on genital sites like the endometrium, whichis located close to the amniotic membranes, posing health risks forthe pregnancy. Future research must…" @default.
- W2890219979 created "2018-09-27" @default.
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- W2890219979 date "2014-01-01" @default.
- W2890219979 modified "2023-09-27" @default.
- W2890219979 title "The association between genital mycoplasmas and bacterial vaginosis in pregnant women with or without genital symptoms" @default.
- W2890219979 hasPublicationYear "2014" @default.
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