Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890223629> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W2890223629 abstract "e23038 Background: Colorectal cancer (CRC) is the second leading cause of cancer death worldwide. Immunoscore has been shown to be a very powerful prognositc indicator in patients with clinically localized colorectal cancer, with no detectable tumour spread to lymph nodes or distant organs. These patients are usually treated with only surgical removal of the tumour; however, approximately 25% of these patients will have recurrence of their disease, indicating that occult metastases were already present at the time of curative surgery. VEGF is the factor responsible for neoangiogenesis and it is being considered as a possible prognostic marker of disease progression. Transforming growth factor-beta (TGF-beta) is also neoangiogenic and a highly immunosuppressive factor. The purpose of this study was to monitor the immune response in patients with stage II and III CRC, with a focus on cellular as well as humoral immunity. TGF-beta and VEGF levels were followed. Methods: 25 patients with stage II and III colon cancer included in the research project received routine cancer teratment. Basic parameters - histological type and grade - were established at baseline. Patients were evaluated by a clinical immunooncolgist to exclude any immune disorders of allergic or autoimmune origin. TGF-beta and VEGF were measured using ELISA, and anti-tumour cellular immunity (CD4, CD8, T-reg, B cells ) were measured via flow cytometry. Results: In patients with stage II and III colorectal cancer, predominantly a depression in cellular immunity was seen. Plasma levels of immunglobulins were also reduced, particularly the IgG4 subtype. Most patients showed some clinical symptoms of immunodeficiency, such as frequent respiratory tract infections and/or herpetic infections. TGF-beta and VEGF plasma levels were increased. Conclusions: The correlation of these neoangiogenic and immunosuppressive factors, as well as the state of anticancer immunity with the clinical outcome of the patients, could help in the future as a prognostic marker and contribute to the selection of targeted immune therapy in patients with colorectal cancer. Dedication: Ggrant of Czech Ministery of Health, 15-28188A, League against cancer and PRVOUK-P-27/LF1/1" @default.
- W2890223629 created "2018-09-27" @default.
- W2890223629 creator A5000705184 @default.
- W2890223629 creator A5004320744 @default.
- W2890223629 creator A5022138433 @default.
- W2890223629 creator A5024999169 @default.
- W2890223629 creator A5028273148 @default.
- W2890223629 creator A5049585448 @default.
- W2890223629 creator A5076719276 @default.
- W2890223629 creator A5078115685 @default.
- W2890223629 creator A5083578485 @default.
- W2890223629 creator A5084646108 @default.
- W2890223629 creator A5087027102 @default.
- W2890223629 date "2017-05-20" @default.
- W2890223629 modified "2023-09-27" @default.
- W2890223629 title "Immunomonitoring in patients with stage II and III colon cancer." @default.
- W2890223629 doi "https://doi.org/10.1200/jco.2017.35.15_suppl.e23038" @default.
- W2890223629 hasPublicationYear "2017" @default.
- W2890223629 type Work @default.
- W2890223629 sameAs 2890223629 @default.
- W2890223629 citedByCount "0" @default.
- W2890223629 crossrefType "journal-article" @default.
- W2890223629 hasAuthorship W2890223629A5000705184 @default.
- W2890223629 hasAuthorship W2890223629A5004320744 @default.
- W2890223629 hasAuthorship W2890223629A5022138433 @default.
- W2890223629 hasAuthorship W2890223629A5024999169 @default.
- W2890223629 hasAuthorship W2890223629A5028273148 @default.
- W2890223629 hasAuthorship W2890223629A5049585448 @default.
- W2890223629 hasAuthorship W2890223629A5076719276 @default.
- W2890223629 hasAuthorship W2890223629A5078115685 @default.
- W2890223629 hasAuthorship W2890223629A5083578485 @default.
- W2890223629 hasAuthorship W2890223629A5084646108 @default.
- W2890223629 hasAuthorship W2890223629A5087027102 @default.
- W2890223629 hasConcept C121608353 @default.
- W2890223629 hasConcept C126322002 @default.
- W2890223629 hasConcept C141071460 @default.
- W2890223629 hasConcept C143998085 @default.
- W2890223629 hasConcept C146357865 @default.
- W2890223629 hasConcept C151730666 @default.
- W2890223629 hasConcept C526805850 @default.
- W2890223629 hasConcept C71924100 @default.
- W2890223629 hasConcept C86803240 @default.
- W2890223629 hasConceptScore W2890223629C121608353 @default.
- W2890223629 hasConceptScore W2890223629C126322002 @default.
- W2890223629 hasConceptScore W2890223629C141071460 @default.
- W2890223629 hasConceptScore W2890223629C143998085 @default.
- W2890223629 hasConceptScore W2890223629C146357865 @default.
- W2890223629 hasConceptScore W2890223629C151730666 @default.
- W2890223629 hasConceptScore W2890223629C526805850 @default.
- W2890223629 hasConceptScore W2890223629C71924100 @default.
- W2890223629 hasConceptScore W2890223629C86803240 @default.
- W2890223629 hasLocation W28902236291 @default.
- W2890223629 hasOpenAccess W2890223629 @default.
- W2890223629 hasPrimaryLocation W28902236291 @default.
- W2890223629 hasRelatedWork W1542945320 @default.
- W2890223629 hasRelatedWork W2031679057 @default.
- W2890223629 hasRelatedWork W2076084312 @default.
- W2890223629 hasRelatedWork W2371284651 @default.
- W2890223629 hasRelatedWork W2429603122 @default.
- W2890223629 hasRelatedWork W2524245613 @default.
- W2890223629 hasRelatedWork W2583898631 @default.
- W2890223629 hasRelatedWork W2589139675 @default.
- W2890223629 hasRelatedWork W2603655246 @default.
- W2890223629 hasRelatedWork W2784925143 @default.
- W2890223629 hasRelatedWork W2891084787 @default.
- W2890223629 hasRelatedWork W2904142576 @default.
- W2890223629 hasRelatedWork W2904406463 @default.
- W2890223629 hasRelatedWork W2941008321 @default.
- W2890223629 hasRelatedWork W2992231914 @default.
- W2890223629 hasRelatedWork W3002016433 @default.
- W2890223629 hasRelatedWork W3005463241 @default.
- W2890223629 hasRelatedWork W3029130903 @default.
- W2890223629 hasRelatedWork W3165626622 @default.
- W2890223629 hasRelatedWork W2177071494 @default.
- W2890223629 isParatext "false" @default.
- W2890223629 isRetracted "false" @default.
- W2890223629 magId "2890223629" @default.
- W2890223629 workType "article" @default.