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• W2890233486 abstract "Coarctation of the aorta (CoA) can be treated using surgery, balloon angioplasty, or stent implantation. Although short-term results are excellent with all three treatment modalities, long-term cardiovascular (CV) morbidity and mortality remain high, likely due to persistently abnormal vascular function. The effects of treatment modality on long-term vascular function remain uncharacterized. The goal of this study is to assess vascular function in this patient population for comparison among the treatment modalities.We will prospectively assess vascular Afunction in large and small arteries fusing multiple noninvasive modalities and compare the results among the three groups of CoA patients previously treated using surgery, balloon angioplasty, or stent implantation after frequency matching for confounding variables. A comprehensive vascular function assessment protocol has been created to be used in 7 centers. Our primary outcome is arterial stiffness measured by arterial tonometry. Inclusion and exclusion criteria have been carefully established after consideration of several potential confounders. Sample size has been calculated for the primary outcome variable.Treatment modalities for CoA may have distinct impact on large and small arterial vascular function. The results of this study will help identify the treatment modality that is associated with the most optimal level of vascular function, which, in the long term, may reduce CV risk." @default.
• W2890233486 created "2018-09-27" @default.
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• W2890233486 date "2018-01-01" @default.
• W2890233486 modified "2023-09-27" @default.
• W2890233486 title "Rationale and design of long-term outcomes and vascular evaluation after successful coarctation of the aorta treatment study" @default.
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• W2890233486 doi "https://doi.org/10.4103/apc.apc_64_18" @default.
• W2890233486 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6146860" @default.
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• W2890233486 hasPublicationYear "2018" @default.
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