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• W2890236311 startingPage "409888" @default.
• W2890236311 abstract "The origins of complex multicellular physiology lie in the evolution of gene expression. Genes express differentially among organs as organisms evolve, but it is not well understood whether expression in certain organs increases the probability that they will be repurposed for expression in other organs. To examine this question, we amalgamated 1,903 RNA-seq datasets from 182 research projects, including 6 organs in 21 vertebrate species. We used various automated quality controls to eliminate project-specific biases, and defined expression regime evolution using tree-based Ornstein-Uhlenbeck models, allowing us to reconstruct evolutionary pathways of gene-family-wise expression on a genome-wide scale. Fluxes in organ-specific gene expression were non-random, suggesting that some ancestral expression patterns strongly preadapted genes for expression in certain organs, while others did not. For example, brain, ovary, and testis tend to change expression from one to another, while kidney and liver form a separate loop of gene expression evolution, illustrating a strong modularity of gene exchange among vertebrate organs. More subtle but significant differences depended on the type of gene duplication. Notably, RNA-based gene duplications tended to generate asymmetric exchange fluxes between organs. This detailed view of the evolutionary dynamics of gene expression supports a major role for preadaptive pathways." @default.
• W2890236311 created "2018-09-27" @default.
• W2890236311 creator A5004491433 @default.
• W2890236311 creator A5029592340 @default.
• W2890236311 date "2018-09-05" @default.
• W2890236311 modified "2023-09-24" @default.
• W2890236311 title "Amalgamated cross-species transcriptomes indicate organ-specific preadaptation for functional shifts in gene expression" @default.
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