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• W2890237614 endingPage "262" @default.
• W2890237614 startingPage "231" @default.
• W2890237614 abstract "Development of the epidermis is marked by terminal differentiation of keratinocytes. The mechanisms that drive this process at the chromatin level are poorly understood. However, recent genomics approaches, including comparative genomic studies, ENCODE data, and biochemical studies to elucidate the 3-dimensional genome architecture with next-generation sequencing technology, have greatly advanced our understanding of the molecular mechanisms that govern epidermal differentiation. Specifically, the identification of enhancers, a class of regulatory elements, and their role in driving key transcriptional events has revealed novel molecular mechanisms for epidermal development. Here we discuss the history of the “enhancer” concept and our current understanding of enhancer-promoter interactions that drive transcriptional activation for epidermal differentiation." @default.
• W2890237614 created "2018-09-27" @default.
• W2890237614 creator A5039411308 @default.
• W2890237614 creator A5057835525 @default.
• W2890237614 date "2018-01-01" @default.
• W2890237614 modified "2023-09-26" @default.
• W2890237614 title "Enhancer-Promoter Interactions and Their Role in the Control of Epidermal Differentiation" @default.
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