Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890253893> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2890253893 endingPage "77" @default.
- W2890253893 startingPage "61" @default.
- W2890253893 abstract "Physiologically based pharmacokinetic (PBPK) models enable simulations of absorption, distribution, metabolism, and elimination of chemicals from the body. Model evaluation is a key step in the PBPK model development processes whereby model predictions are compared to pharmacokinetic (PK) data. A prerequisite for PBPK model evaluation has always been the availability of PK data for the modeled compound, a requirement which has limited the use and acceptance of PBPK models since PK data is often limited or not available. The current work tests the hypothesis that an adequately developed PBPK model for a target chemical (chemical with no PK data) can be evaluated using PK data from a source chemical (chemical with existing PK data). Two different approaches for identifying the source chemical, a structural PK analog and functional PK analog technique, are used to evaluate a series of oral human PBPK models. Results show that both analog approaches can identify PK analogs which display similar PK as the target chemical and can be used as alternative ways for evaluating PBPK models. As animal free safety assessment strategies continue to develop, it's important to develop alternative approaches for PBPK model evaluation which does not rely on generating new PK data." @default.
- W2890253893 created "2018-09-27" @default.
- W2890253893 creator A5065039350 @default.
- W2890253893 date "2018-11-01" @default.
- W2890253893 modified "2023-09-27" @default.
- W2890253893 title "Structural and functional pharmacokinetic analogs for physiologically based pharmacokinetic (PBPK) model evaluation" @default.
- W2890253893 cites W1498305210 @default.
- W2890253893 cites W1574554412 @default.
- W2890253893 cites W1894357711 @default.
- W2890253893 cites W1963544556 @default.
- W2890253893 cites W1970111863 @default.
- W2890253893 cites W1971608985 @default.
- W2890253893 cites W1974843915 @default.
- W2890253893 cites W1976910683 @default.
- W2890253893 cites W1990287431 @default.
- W2890253893 cites W2004199171 @default.
- W2890253893 cites W2004670440 @default.
- W2890253893 cites W2010609085 @default.
- W2890253893 cites W2023484750 @default.
- W2890253893 cites W2024226989 @default.
- W2890253893 cites W2024303294 @default.
- W2890253893 cites W2024879879 @default.
- W2890253893 cites W2034200280 @default.
- W2890253893 cites W2038153892 @default.
- W2890253893 cites W2050564499 @default.
- W2890253893 cites W2054693391 @default.
- W2890253893 cites W2060992818 @default.
- W2890253893 cites W2062657108 @default.
- W2890253893 cites W2074119331 @default.
- W2890253893 cites W2077483199 @default.
- W2890253893 cites W2080340920 @default.
- W2890253893 cites W2087862188 @default.
- W2890253893 cites W2105649494 @default.
- W2890253893 cites W2108458189 @default.
- W2890253893 cites W2109865776 @default.
- W2890253893 cites W2123658820 @default.
- W2890253893 cites W2266055629 @default.
- W2890253893 cites W2277557056 @default.
- W2890253893 cites W2345568057 @default.
- W2890253893 cites W2470404816 @default.
- W2890253893 cites W2481597297 @default.
- W2890253893 cites W2500341359 @default.
- W2890253893 cites W2522795135 @default.
- W2890253893 cites W265312277 @default.
- W2890253893 cites W2733197584 @default.
- W2890253893 cites W2745718614 @default.
- W2890253893 cites W2772288444 @default.
- W2890253893 cites W2782426740 @default.
- W2890253893 cites W2791381924 @default.
- W2890253893 doi "https://doi.org/10.1016/j.yrtph.2018.09.008" @default.
- W2890253893 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30201539" @default.
- W2890253893 hasPublicationYear "2018" @default.
- W2890253893 type Work @default.
- W2890253893 sameAs 2890253893 @default.
- W2890253893 citedByCount "22" @default.
- W2890253893 countsByYear W28902538932019 @default.
- W2890253893 countsByYear W28902538932020 @default.
- W2890253893 countsByYear W28902538932021 @default.
- W2890253893 countsByYear W28902538932022 @default.
- W2890253893 countsByYear W28902538932023 @default.
- W2890253893 crossrefType "journal-article" @default.
- W2890253893 hasAuthorship W2890253893A5065039350 @default.
- W2890253893 hasConcept C112705442 @default.
- W2890253893 hasConcept C127413603 @default.
- W2890253893 hasConcept C183696295 @default.
- W2890253893 hasConcept C185592680 @default.
- W2890253893 hasConcept C185867374 @default.
- W2890253893 hasConcept C41008148 @default.
- W2890253893 hasConcept C71924100 @default.
- W2890253893 hasConcept C98274493 @default.
- W2890253893 hasConceptScore W2890253893C112705442 @default.
- W2890253893 hasConceptScore W2890253893C127413603 @default.
- W2890253893 hasConceptScore W2890253893C183696295 @default.
- W2890253893 hasConceptScore W2890253893C185592680 @default.
- W2890253893 hasConceptScore W2890253893C185867374 @default.
- W2890253893 hasConceptScore W2890253893C41008148 @default.
- W2890253893 hasConceptScore W2890253893C71924100 @default.
- W2890253893 hasConceptScore W2890253893C98274493 @default.
- W2890253893 hasLocation W28902538931 @default.
- W2890253893 hasLocation W28902538932 @default.
- W2890253893 hasOpenAccess W2890253893 @default.
- W2890253893 hasPrimaryLocation W28902538931 @default.
- W2890253893 hasRelatedWork W2000200648 @default.
- W2890253893 hasRelatedWork W2034505552 @default.
- W2890253893 hasRelatedWork W2068005011 @default.
- W2890253893 hasRelatedWork W2592362637 @default.
- W2890253893 hasRelatedWork W2620300421 @default.
- W2890253893 hasRelatedWork W2748952813 @default.
- W2890253893 hasRelatedWork W2899084033 @default.
- W2890253893 hasRelatedWork W2909814037 @default.
- W2890253893 hasRelatedWork W4206966109 @default.
- W2890253893 hasRelatedWork W4308352595 @default.
- W2890253893 hasVolume "99" @default.
- W2890253893 isParatext "false" @default.
- W2890253893 isRetracted "false" @default.
- W2890253893 magId "2890253893" @default.
- W2890253893 workType "article" @default.