FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890256678> ?p ?o ?g. }

• W2890256678 endingPage "iii246" @default.
• W2890256678 startingPage "iii245" @default.
• W2890256678 abstract "The role of re-irradiation is still under investigation, particularly regarding to the appropriate patients selection, the time interval between the first and second irradiation, and the optimal RT schedule. The aim of the present study was to evaluate clinical outcome of patients with recurrent glioma underwent re-irradiation in 13 Italian Centers. Data of 321 recurrent glioma patients underwent re-irradiation were reviewed. The data collection focused on patients, tumor, and treatments characteristics at diagnosis and at recurrence, interval time between diagnosis and local relapse, features of re-irradiation concerning target volume, total doses and fractionations used, acute and late toxicity. Overall survival (OS) was calculated from the date of re-irradiation to the time of death or to the last follow-up examination. Among 321 patients evaluated, 223 had primary diagnosis of glioblastoma, 81 grade III gliomas, 17 low grade glioma. At recurrent time the median age was 53 years (range 20–82 years) and the majority (92%) of patients had a KPS ≥70. Re-irradiation was performed in all 321 patients at a median time of 15 months (range 3–340 months). The median total dose prescribed was 25 Gy in 5 fractions (range 10–52.5Gy in 1–15 fractions). A combined treatment, including surgery and/or chemotherapy was carried out in 102 patients while 219 received radiation therapy only. The median follow up time was 8.2 months (range 2–73 months) for the whole cohort and 17.6 months (range 3–67.7 months) for the alive patients. The median OS time, and the 6,12,24 months OS rate were 9.5 months (95%CI 8.2–10.4), 84% (95%CI 80–88), 47% (95%CI41-52), and 22% (95%CI17-27), respectively. At the last observation time 54 are alive and 267 dead. Acute grade 1–2 toxicity was recorded in 43 (13.4%) patients. Grade 1 radionecrosis occurred in 16 patients, grade 2 in 12, and grade 3 in 1. Univariate analysis showed the statistical significance of the extent of surgical resection, histology of primary tumors, IDH and MGMT status at diagnosis; at relapse time age, KPS, the interval between first and second radiation therapy, and the combined treatment performed were recorded as influencing survival. Age, KPS, histology, IDH and MGMT status were confirmed as influencing survival also on multivariate analysis. According to our results, re-irradiation could be considered a safe and feasible therapeutic option for recurrent high grade glioma. Multidisciplinary evaluation is mandatory to assure the best treatment where local therapy is part of multimodal management." @default.
• W2890256678 created "2018-09-27" @default.
• W2890256678 creator A5001488294 @default.
• W2890256678 creator A5013108855 @default.
• W2890256678 creator A5015709589 @default.
• W2890256678 creator A5034546205 @default.
• W2890256678 creator A5066556446 @default.
• W2890256678 creator A5067643297 @default.
• W2890256678 creator A5067723237 @default.
• W2890256678 creator A5078658404 @default.
• W2890256678 creator A5080572439 @default.
• W2890256678 creator A5084086061 @default.
• W2890256678 date "2018-09-01" @default.
• W2890256678 modified "2023-10-18" @default.
• W2890256678 title "P01.069 Re-irradiation for recurrent glioma: outcome evaluation, toxicity and prognostic factors assessment. A multicenter retrospective study by the Brain-Study-Group of the Radiation Oncology Italian Association (AIRO)" @default.
• W2890256678 doi "https://doi.org/10.1093/neuonc/noy139.111" @default.
• W2890256678 hasPublicationYear "2018" @default.
• W2890256678 type Work @default.
• W2890256678 sameAs 2890256678 @default.
• W2890256678 citedByCount "0" @default.
• W2890256678 crossrefType "journal-article" @default.
• W2890256678 hasAuthorship W2890256678A5001488294 @default.
• W2890256678 hasAuthorship W2890256678A5013108855 @default.
• W2890256678 hasAuthorship W2890256678A5015709589 @default.
• W2890256678 hasAuthorship W2890256678A5034546205 @default.
• W2890256678 hasAuthorship W2890256678A5066556446 @default.
• W2890256678 hasAuthorship W2890256678A5067643297 @default.
• W2890256678 hasAuthorship W2890256678A5067723237 @default.
• W2890256678 hasAuthorship W2890256678A5078658404 @default.
• W2890256678 hasAuthorship W2890256678A5080572439 @default.
• W2890256678 hasAuthorship W2890256678A5084086061 @default.
• W2890256678 hasBestOaLocation W28902566781 @default.
• W2890256678 hasConcept C126322002 @default.
• W2890256678 hasConcept C141071460 @default.
• W2890256678 hasConcept C167135981 @default.
• W2890256678 hasConcept C2776694085 @default.
• W2890256678 hasConcept C2778227246 @default.
• W2890256678 hasConcept C2779709957 @default.
• W2890256678 hasConcept C29730261 @default.
• W2890256678 hasConcept C2989005 @default.
• W2890256678 hasConcept C502942594 @default.
• W2890256678 hasConcept C509974204 @default.
• W2890256678 hasConcept C71924100 @default.
• W2890256678 hasConcept C72563966 @default.
• W2890256678 hasConceptScore W2890256678C126322002 @default.
• W2890256678 hasConceptScore W2890256678C141071460 @default.
• W2890256678 hasConceptScore W2890256678C167135981 @default.
• W2890256678 hasConceptScore W2890256678C2776694085 @default.
• W2890256678 hasConceptScore W2890256678C2778227246 @default.
• W2890256678 hasConceptScore W2890256678C2779709957 @default.
• W2890256678 hasConceptScore W2890256678C29730261 @default.
• W2890256678 hasConceptScore W2890256678C2989005 @default.
• W2890256678 hasConceptScore W2890256678C502942594 @default.
• W2890256678 hasConceptScore W2890256678C509974204 @default.
• W2890256678 hasConceptScore W2890256678C71924100 @default.
• W2890256678 hasConceptScore W2890256678C72563966 @default.
• W2890256678 hasIssue "suppl_3" @default.
• W2890256678 hasLocation W28902566781 @default.
• W2890256678 hasLocation W28902566782 @default.
• W2890256678 hasOpenAccess W2890256678 @default.
• W2890256678 hasPrimaryLocation W28902566781 @default.
• W2890256678 hasRelatedWork W165245056 @default.
• W2890256678 hasRelatedWork W1988030834 @default.
• W2890256678 hasRelatedWork W2094700497 @default.
• W2890256678 hasRelatedWork W2347438058 @default.
• W2890256678 hasRelatedWork W2347550994 @default.
• W2890256678 hasRelatedWork W2351388913 @default.
• W2890256678 hasRelatedWork W2358125876 @default.
• W2890256678 hasRelatedWork W2370643400 @default.
• W2890256678 hasRelatedWork W4220939315 @default.
• W2890256678 hasRelatedWork W4291189777 @default.
• W2890256678 hasVolume "20" @default.
• W2890256678 isParatext "false" @default.
• W2890256678 isRetracted "false" @default.
• W2890256678 magId "2890256678" @default.
• W2890256678 workType "article" @default.