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• W2890265890 abstract "This work illustrates a new role for the membranotropic peptide gH625 and its derivative gH625-GCGKKK in impairing formation of polymicrobial biofilms. Mixed biofilms composed of Candida and bacterial species cause frequently infections and failure of medical silicone devices and also show a major drug resistance than single-species biofilms. Inhibition and eradication of biofilms were evaluated by complementary methods: XTT-reduction, and crystal violet staining (CV). Our results indicate that gH625-GCGKKKK, better than the native peptide, strongly inhibited formation of mixed biofilms of clinical isolates of C. tropicalis/S. marcescens and C. tropicalis/S. aureus and reduced the biofilm architecture, interfering with cell adhesion and polymeric matrix, as well as eradicated the long-term polymicrobial biofilms on silicone surface." @default.
• W2890265890 created "2018-09-27" @default.
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• W2890265890 date "2018-12-01" @default.
• W2890265890 modified "2023-09-27" @default.
• W2890265890 title "Polymicrobial antibiofilm activity of the membranotropic peptide gH625 and its analogue" @default.
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• W2890265890 doi "https://doi.org/10.1016/j.micpath.2018.09.027" @default.
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